Aquaporin-2 membrane targeting: still a conundrum

Emma Tina Bisgaard Olesen; Robert A. Fenton

doi:10.1152/ajprenal.00010.2017

Aquaporin-2 membrane targeting: still a conundrum

Emma Tina Bisgaard Olesen, Robert A. Fenton

23 Citations (Scopus)

Abstract

The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis. In this brief review we assess the role of cyclic adenosine monophosphate (cAMP) and discuss the emerging concept that type 2 AVP receptor (V2R)-mediated AQP2 trafficking is cAMP-independent.

Original language	English
Journal	American Journal of Physiology: Renal Physiology
Volume	312
Issue number	4
Pages (from-to)	F744-F747
ISSN	1931-857X
DOIs	https://doi.org/10.1152/ajprenal.00010.2017
Publication status	Published - 7 Apr 2017

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AB - The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis. In this brief review we assess the role of cyclic adenosine monophosphate (cAMP) and discuss the emerging concept that type 2 AVP receptor (V2R)-mediated AQP2 trafficking is cAMP-independent.

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Aquaporin-2 membrane targeting: still a conundrum

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