Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

Hiroshi Ueda; Wenqi Wu; Korbinian Lobmann; Holger Grohganz; Anette Mullertz; Thomas Rades

doi:10.1021/acs.molpharmaceut.8b00174

Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

Hiroshi Ueda, Wenqi Wu, Korbinian Lobmann, Holger Grohganz, Anette Mullertz, Thomas Rades

29 Citationer (Scopus)

Originalsprog	Engelsk
Tidsskrift	Molecular Pharmaceutics
Vol/bind	15
Udgave nummer	5
Sider (fra-til)	2036-2044
ISSN	1543-8384
DOI	https://doi.org/10.1021/acs.molpharmaceut.8b00174
Status	Udgivet - 7 maj 2018

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10.1021/acs.molpharmaceut.8b00174

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Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine. / Ueda, Hiroshi; Wu, Wenqi; Lobmann, Korbinian et al.

I: Molecular Pharmaceutics, Bind 15, Nr. 5, 07.05.2018, s. 2036-2044.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ueda, H, Wu, W, Lobmann, K , Grohganz, H , Mullertz, A & Rades, T 2018, 'Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine', Molecular Pharmaceutics, bind 15, nr. 5, s. 2036-2044. https://doi.org/10.1021/acs.molpharmaceut.8b00174

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keywords = "co-amorphous, amorphous, glass transition temperature, intermolecular interaction, salt formation, crystallization",

author = "Hiroshi Ueda and Wenqi Wu and Korbinian Lobmann and Holger Grohganz and Anette Mullertz and Thomas Rades",

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AU - Ueda, Hiroshi

AU - Wu, Wenqi

AU - Lobmann, Korbinian

AU - Grohganz, Holger

AU - Mullertz, Anette

AU - Rades, Thomas

PY - 2018/5/7

Y1 - 2018/5/7

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KW - amorphous

KW - glass transition temperature

KW - intermolecular interaction

KW - salt formation

KW - crystallization

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DO - 10.1021/acs.molpharmaceut.8b00174

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Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

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