@article{cea0dbd0accb11ddb538000ea68e967b,
title = "Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells.",
abstract = "Malignant transformation is known to be associated with changes in cell surface carbohydrate-architecture, which can be detected by lectins. In the present study, Maackia amurensis agglutinin (MAA), specific for NeuNAcalpha(2-->3)Gal/GalNAc showed strong binding with lymphoblasts of children having acute lymphoblastic leukemia (ALL) as compared to cells from children with non-hematological disorders ({"}Controls{"}). MAA recognized a 66 kDa sialoglycoprotein present in membrane fraction of ALL cells. Moreover, MAA induced apoptosis in ALL cells was found to be reduced significantly in presence of GM2/IgG(MAA). Thus, MAA has a potential to be used as diagnostic and therapeutic agent in case of childhood-ALL.",
author = "Sarika Kapoor and Ram Marwaha and Siddhartha Majumdar and Sujata Ghosh",
note = "Keywords: Apoptosis; Blotting, Western; Cell Line; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Glycoproteins; Humans; Lymphocytes; Male; Neuraminidase; Phytohemagglutinins; Precursor Cell Lymphoblastic Leukemia-Lymphoma",
year = "2007",
doi = "10.1016/j.leukres.2007.08.007",
language = "English",
volume = "32",
pages = "559--67",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Pergamon Press",
number = "4",
}