Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx

TY - JOUR

T1 - Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx

AU - Oketch-Rabah, H A

AU - Brøgger Christensen, S

AU - Frydenvang, K

AU - Dossaji, S F

AU - Theander, T G

AU - Cornett, C

AU - Watkins, W M

AU - Kharazmi, A

AU - Lemmich, E

N1 - Keywords: Animals; Antiprotozoal Agents; Cell Survival; Humans; Leishmania major; Lymphocytes; Models, Molecular; Molecular Conformation; Molecular Structure; Plant Extracts; Plant Leaves; Plants, Medicinal; Sesquiterpenes, Germacrane

PY - 1998

Y1 - 1998

N2 - Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.

AB - Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.

M3 - Journal article

C2 - 9741304

SN - 0032-0943

VL - 64

SP - 559

EP - 562

JO - Planta Medica

JF - Planta Medica

IS - 6

ER -