Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes

Jiwan Kumar Chettri; Foojan Mehrdana; E.B Hansen; A Ebbensgaard; M.T Overgaard; A.H Lauritsen; I Dalsgaard; Kurt Buchmann

doi:10.1111/jfd.12497

Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes

Jiwan Kumar Chettri, Foojan Mehrdana, E.B Hansen, A Ebbensgaard, M.T Overgaard, A.H Lauritsen, I Dalsgaard, Kurt Buchmann

5 Citationer (Scopus)

Abstract

The antimicrobial peptide CAP18 has been demonstrated to have a strong in vitro bactericidal effect on Yersinia ruckeri, but its activity in vivo has not been described. In this work, we investigated whether CAP18 protects rainbow trout Oncorhynchus mykiss (Walbaum) against enteric red mouth disease caused by this pathogen either following i.p. injection or by oral administration (in feed). It was found that injection of CAP18 into juvenile rainbow trout before exposure to Y. ruckeri was associated with lowered mortality compared to non-medicated fish although it was less effective than the conventional antibiotic oxolinic acid. Oral administration of CAP18 to trout did not prevent infection. The proteolytic effect of secretions on the peptide CAP18 in the fish gastrointestinal tract is suggested to account for the inferior effect of oral administration.

Originalsprog	Engelsk
Tidsskrift	Journal of Fish Diseases
Vol/bind	40
Udgave nummer	1
Sider (fra-til)	97-104
ISSN	0140-7775
DOI	https://doi.org/10.1111/jfd.12497
Status	Udgivet - 1 jan. 2017

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10.1111/jfd.12497

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Chettri, J. K., Mehrdana, F., Hansen, E. B., Ebbensgaard, A., Overgaard, M. T., Lauritsen, A. H., Dalsgaard, I., & Buchmann, K. (2017). Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes. Journal of Fish Diseases, 40(1), 97-104. https://doi.org/10.1111/jfd.12497

Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes. / Chettri, Jiwan Kumar; Mehrdana, Foojan; Hansen, E.B et al.

I: Journal of Fish Diseases, Bind 40, Nr. 1, 01.01.2017, s. 97-104.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Chettri, JK, Mehrdana, F, Hansen, EB, Ebbensgaard, A, Overgaard, MT, Lauritsen, AH, Dalsgaard, I & Buchmann, K 2017, 'Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes', Journal of Fish Diseases, bind 40, nr. 1, s. 97-104. https://doi.org/10.1111/jfd.12497

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abstract = "The antimicrobial peptide CAP18 has been demonstrated to have a strong in vitro bactericidal effect on Yersinia ruckeri, but its activity in vivo has not been described. In this work, we investigated whether CAP18 protects rainbow trout Oncorhynchus mykiss (Walbaum) against enteric red mouth disease caused by this pathogen either following i.p. injection or by oral administration (in feed). It was found that injection of CAP18 into juvenile rainbow trout before exposure to Y. ruckeri was associated with lowered mortality compared to non-medicated fish although it was less effective than the conventional antibiotic oxolinic acid. Oral administration of CAP18 to trout did not prevent infection. The proteolytic effect of secretions on the peptide CAP18 in the fish gastrointestinal tract is suggested to account for the inferior effect of oral administration.",

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Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes

Abstract

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