@article{c9ec1fab9f194433b8a70b558ea1251f,
title = "Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study",
abstract = "BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Body Height/genetics, Carcinoma, Ovarian Epithelial/epidemiology, Case-Control Studies, Female, Genetic Predisposition to Disease, Geography, Humans, Mendelian Randomization Analysis, Middle Aged, Ovarian Neoplasms/epidemiology, Risk Factors, Young Adult",
author = "Dixon-Suen, {Suzanne C} and Nagle, {Christina M} and Thrift, {Aaron P} and Pharoah, {Paul D P} and Ailith Ewing and Pearce, {Celeste Leigh} and Wei Zheng and Georgia Chenevix-Trench and Fasching, {Peter A} and Beckmann, {Matthias W} and Diether Lambrechts and Ignace Vergote and Sandrina Lambrechts and {Van Nieuwenhuysen}, Els and Rossing, {Mary Anne} and Doherty, {Jennifer A} and Wicklund, {Kristine G} and Jenny Chang-Claude and Jung, {Audrey Y} and Moysich, {Kirsten B} and Kunle Odunsi and Goodman, {Marc T} and Wilkens, {Lynne R} and Thompson, {Pamela J} and Shvetsov, {Yurii B} and Thilo D{\"o}rk and Tjoung-Won Park-Simon and Peter Hillemanns and Natalia Bogdanova and Ralf Butzow and Heli Nevanlinna and Pelttari, {Liisa M} and Arto Leminen and Francesmary Modugno and Ness, {Roberta B} and Edwards, {Robert P} and Kelley, {Joseph L} and Florian Heitz and {du Bois}, Andreas and Philipp Harter and Ira Schwaab and Karlan, {Beth Y} and Jenny Lester and Sandra Orsulic and Rimel, {Bobbie J} and Kj{\ae}r, {Susanne K} and Estrid H{\o}gdall and Allan Jensen and H{\o}gdall, {Claus K} and Lene Lundvall and {Australian Ovarian Cancer Study Group}",
year = "2018",
month = apr,
day = "1",
doi = "10.1038/s41416-018-0011-3",
language = "English",
volume = "118",
pages = "1123--1129",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "nature publishing group",
number = "8",
}
