Adipose tissue PCB levels and CYP1B1 and COMT genotypes in relation to breast cancer risk in postmenopausal Danish women

TY - JOUR

T1 - Adipose tissue PCB levels and CYP1B1 and COMT genotypes in relation to breast cancer risk in postmenopausal Danish women

AU - Bräuner, Elvira V

AU - Loft, Steffen

AU - Wellejus, Anja

AU - Autrup, Herman

AU - Tjønneland, Anne

AU - Raaschou-Nielsen, Ole

PY - 2014/5/4

Y1 - 2014/5/4

N2 - Exposure to PCBs may be an etiologic factor for breast cancer. The cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) enzymes are involved in estrogen metabolism and PCB metabolism, both of which may relate to breast cancer susceptibility. Polymorphisms in genes regulating these enzymes control efficiency. Our objective was to assess whether CYP1B1 and COMT gene polymorphisms modulate the effect of PCBs in breast cancer risk, among postmenopausal Danish women. Neither CYP1B1 Leu432Val polymorphisms nor adipose tissue PCBs were independently associated with breast cancer risk. When assessing the independent effect of the COMT Val158Met polymorphism, we observed reduced risk for breast cancer amongst hormone replacement therapy using women who were homozygous carriers of the variant allele compared with those carrying the wild-type variant (RR = 0.41; 95% CI: 0.29-0.89). We found no statistically significant interactions between any of the PCB groups and CYP1B1 or COMT polymorphisms on the risk of breast cancer.

AB - Exposure to PCBs may be an etiologic factor for breast cancer. The cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) enzymes are involved in estrogen metabolism and PCB metabolism, both of which may relate to breast cancer susceptibility. Polymorphisms in genes regulating these enzymes control efficiency. Our objective was to assess whether CYP1B1 and COMT gene polymorphisms modulate the effect of PCBs in breast cancer risk, among postmenopausal Danish women. Neither CYP1B1 Leu432Val polymorphisms nor adipose tissue PCBs were independently associated with breast cancer risk. When assessing the independent effect of the COMT Val158Met polymorphism, we observed reduced risk for breast cancer amongst hormone replacement therapy using women who were homozygous carriers of the variant allele compared with those carrying the wild-type variant (RR = 0.41; 95% CI: 0.29-0.89). We found no statistically significant interactions between any of the PCB groups and CYP1B1 or COMT polymorphisms on the risk of breast cancer.

KW - Adipose Tissue

KW - Aryl Hydrocarbon Hydroxylases

KW - Breast Neoplasms

KW - Case-Control Studies

KW - Catechol O-Methyltransferase

KW - Cytochrome P-450 CYP1B1

KW - Data Interpretation, Statistical

KW - Denmark

KW - Female

KW - Genotype

KW - Hormone Replacement Therapy

KW - Humans

KW - Middle Aged

KW - Polychlorinated Biphenyls

KW - Polymorphism, Single Nucleotide

KW - Postmenopause

KW - Prospective Studies

KW - Risk

U2 - 10.1080/09603123.2013.809703

DO - 10.1080/09603123.2013.809703

M3 - Journal article

C2 - 23869875

SN - 0960-3123

VL - 24

SP - 256

EP - 268

JO - International Journal of Environmental Health Research

JF - International Journal of Environmental Health Research

IS - 3

ER -