A role of taurine in mitochondrial function

Svend Høime Hansen; Mogens Larsen Andersen; Claus Cornett; Robert Gradinaru; Niels Grunnet

doi:10.1186/1423-0127-17-S1-S23

A role of taurine in mitochondrial function

Svend Høime Hansen, Mogens Larsen Andersen, Claus Cornett, Robert Gradinaru, Niels Grunnet

Inflammation, Metabolism and Oxidation

81 Citationer (Scopus)

Abstract

The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Taurine is found ubiquitously in animal cells with concentrations in the millimolar range and its pKa value is determined to 9.0 (25°C) and 8.6 (37°C), respectively. Localisation of such a low-molecular buffer in the mitochondrial matrix, transforms the matrix into a biochemical reaction chamber for the important matrix-localised enzyme systems. Three acyl-CoA dehydrogenase enzymes, which are pivotal for beta-oxidation of fatty acids, are demonstrated to have optimal activity in a taurine buffer. By application of the model presented, taurine depletion caused by hyperglycemia could provide a link between mitochondrial dysfunction and diabetes.

Originalsprog	Engelsk
Tidsskrift	Journal of Biomedical Science
Vol/bind	17
Udgave nummer	Suppl. 1
Antal sider	8
ISSN	1021-7770
DOI	https://doi.org/10.1186/1423-0127-17-S1-S23
Status	Udgivet - 2010

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10.1186/1423-0127-17-S1-S23

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abstract = "The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Taurine is found ubiquitously in animal cells with concentrations in the millimolar range and its pKa value is determined to 9.0 (25°C) and 8.6 (37°C), respectively. Localisation of such a low-molecular buffer in the mitochondrial matrix, transforms the matrix into a biochemical reaction chamber for the important matrix-localised enzyme systems. Three acyl-CoA dehydrogenase enzymes, which are pivotal for beta-oxidation of fatty acids, are demonstrated to have optimal activity in a taurine buffer. By application of the model presented, taurine depletion caused by hyperglycemia could provide a link between mitochondrial dysfunction and diabetes.",

author = "Hansen, {Svend H{\o}ime} and Andersen, {Mogens Larsen} and Claus Cornett and Robert Gradinaru and Niels Grunnet",

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T1 - A role of taurine in mitochondrial function

AU - Hansen, Svend Høime

AU - Andersen, Mogens Larsen

AU - Cornett, Claus

AU - Gradinaru, Robert

AU - Grunnet, Niels

PY - 2010

Y1 - 2010

N2 - The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Taurine is found ubiquitously in animal cells with concentrations in the millimolar range and its pKa value is determined to 9.0 (25°C) and 8.6 (37°C), respectively. Localisation of such a low-molecular buffer in the mitochondrial matrix, transforms the matrix into a biochemical reaction chamber for the important matrix-localised enzyme systems. Three acyl-CoA dehydrogenase enzymes, which are pivotal for beta-oxidation of fatty acids, are demonstrated to have optimal activity in a taurine buffer. By application of the model presented, taurine depletion caused by hyperglycemia could provide a link between mitochondrial dysfunction and diabetes.

AB - The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Taurine is found ubiquitously in animal cells with concentrations in the millimolar range and its pKa value is determined to 9.0 (25°C) and 8.6 (37°C), respectively. Localisation of such a low-molecular buffer in the mitochondrial matrix, transforms the matrix into a biochemical reaction chamber for the important matrix-localised enzyme systems. Three acyl-CoA dehydrogenase enzymes, which are pivotal for beta-oxidation of fatty acids, are demonstrated to have optimal activity in a taurine buffer. By application of the model presented, taurine depletion caused by hyperglycemia could provide a link between mitochondrial dysfunction and diabetes.

U2 - 10.1186/1423-0127-17-S1-S23

DO - 10.1186/1423-0127-17-S1-S23

M3 - Journal article

C2 - 20804598

SN - 1021-7770

VL - 17

JO - Journal of Biomedical Science

JF - Journal of Biomedical Science

IS - Suppl. 1

ER -

A role of taurine in mitochondrial function

Abstract

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