@article{dacfa540ebcc11ddbf70000ea68e967b,
title = "A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells",
abstract = "Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes by the T-cell receptor is a key reaction in the specific immune response. Antibodies against peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-cell recognition and might lead to novel approaches in immunotherapy. However, it has proven difficult to generate antibodies with the specificity of T cells by conventional hybridoma techniques. Here we report that the phage display technology is a feasible alternative to generate antibodies recognizing specific, predetermined peptide/MHC complexes.",
author = "Andersen, {P S} and A Stryhn and Hansen, {B E} and L Fugger and J Engberg and S Buus",
note = "Keywords: Amino Acid Sequence; Animals; Antibody Specificity; Bacteriophages; Gene Library; Major Histocompatibility Complex; Mice; Mice, Inbred AKR; Molecular Sequence Data; Peptides; Recombinant Proteins; T-Lymphocytes",
year = "1996",
language = "English",
volume = "93",
pages = "1820--4",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "5",
}