@article{70d2d440fc4d11de825d000ea68e967b,
title = "A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans",
abstract = "Cryptococcus neoformans is a fungal pathogen that causes serious disease in immunocompromised individuals. The organism produces a distinctive polysaccharide capsule that is necessary for its virulence, a predominantly polysaccharide cell wall, and a variety of protein- and lipid-linked glycans. The glycan synthetic pathways of this pathogen are of great interest. Here we report the detection of a novel glycosylphosphotransferase activity in C. neoformans, identification of the corresponding gene, and characterization of the encoded protein. The observed activity is specific for UDP-xylose as a donor and for mannose acceptors and forms a xylose-alpha-1-phosphate-6-mannose linkage. This is the first report of a xylosylphosphotransferase activity in any system.",
author = "Reilly, {Morgann C} and Levery, {Steven B} and Castle, {Sherry A} and Klutts, {J Stacey} and Doering, {Tamara L}",
year = "2009",
doi = "10.1074/jbc.M109.056226",
language = "English",
volume = "284",
pages = "36118--27",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",
number = "52",
}