@article{28c30f70b1c511df825b000ea68e967b,
title = "A {"}new{"} primed lymphocyte typing (PLT) defined DP-antigen associated with a private HLA--DR antigen",
abstract = "We have recently described a {"}new{"} private HLA-DR antigen, DR{"}LTM{"}, which has a frequency of approximately 0.6% in Danes. Primed Lymphocyte Typing (PLT) cells directed towards DR{"}LTM{"}-associated determinants were generated in vitro by haplotype primings in two unrelated families with DR{"}LTM{"} positive individuals. Both PLT-cells reacted in parallel and gave positive reactions with (i) two unrelated and (ii) eight related individuals, all of whom were DR{"}LTM{"}-positive. Both PLT-cells gave negative reactions with (i) 38 unrelated and (ii) 15 related DR{"}LTM{"}-negative individuals. Thus, there was total agreement between the results obtained by HLA-DR typing with the antiserum {"}LTM{"} and by PLT-typing with these two haplotype primed PLT-cells. None of the DP{"}LTM{"}-positive individuals carried more than one of the antigens HLA-Dw/-DRw/DP1-8 and the local specificity D/DP{"}H{"}. Accordingly, this {"}new{"} PLT-defined antigen, DP{"}LTM{"}, most probably belongs to the series of HLA-D/DR-associated DP-antigens previously described.",
author = "N Morling and Jakobsen, {B K} and P Platz and Ryder, {L P} and A Svejgaard and M Thomsen",
note = "Keywords: Arthritis, Juvenile Rheumatoid; B-Lymphocytes; Diabetes Mellitus; Epitopes; Female; Haploidy; Histocompatibility Antigens Class II; Histocompatibility Testing; Humans; Male; Multiple Sclerosis; Protein Biosynthesis",
year = "1980",
language = "English",
volume = "16",
pages = "95--104",
journal = "HLA",
issn = "2059-2302",
publisher = "Wiley",
number = "1",
}