A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Robert A. Scott; Daniel F. Freitag; Li Li; Audrey Y. Chu; Praveen Surendran; Robin Young; Niels Grarup; Alena Stancakova; Yuning Chen; Tibor V. Varga; Hanieh Yaghootkar; Jian'an Luan; Jing Hua Zhao; Sara M. Willems; Jennifer Wessel; Shuai Wang; Nisa Maruthur; Kyriaki Michailidou; Ailith Pirie; Sven J. van der Lee; Christopher Gillson; Ali Amin Al Olama; Philippe Amouyel; Larraitz Arriola; Dominique Arveiler; Iciar Aviles-Olmos; Beverley Balkau; Aurelio Barricarte; Ines Barroso; Sara Benlloch Garcia; Joshua C. Bis; Stefan Blankenberg; Michael Boehnke; Heiner Boeing; Eric Boerwinkle; Ingrid B. Borecki; Jette Bork-Jensen; Sarah Bowden; Carlos Caldas; Muriel Caslake; L. Adrienne Cupples; Carlos Cruchaga; Jacek Czajkowski; Marcel den Hoed; Janet A. Dunn; Helena M. Earl; Georg B. Ehret; Ele Ferrannini; Jean Ferrieres; Thomas Foltynie; Ian Ford; Nita G. Forouhi; Francesco Gianfagna; Carlos Gonzalez; Sara Grioni; Louise Hiller; Jan-Hakan Jansson; Marit E. Jørgensen; J. Wouter Jukema; Rudolf Kaaks; Frank Kee; Nicola D. Kerrison; Timothy J. Key; Jukka Kontto; Zsofia Kote-Jarai; Aldi T. Kraja; Kari Kuulasmaa; Johanna Kuusisto; Allan Linneberg; Chunyu Liu; Galle Marenne; Karen L. Mohlke; Andrew P. Morris; Kenneth Muir; Martina Mueller-Nurasyid; Patricia B. Munroe; Carmen Navarro; Sune F. Nielsen; Peter M. Nilsson; Borge G. Nordestgaard; Chris J. Packard; Domenico Palli; Salvatore Panico; Gina M. Peloso; Markus Perola; Annette Peters; Christopher J. Poole; J. Ramn Quiros; Olov Rolandsson; Carlotta Sacerdote; Veikko Salomaa; Mara-Jose Sanchez; Naveed Sattar; Stephen J. Sharp; Rebecca Sims; Nadia Slimani; Jennifer A. Smith; Deborah J. Thompson; Stella Trompet; Rosario Tumino; Daphne L. van der A; Yvonne T. van der Schouw; Jarmo Virtamo; Mark Walker; Klaudia Walter; Jean E. Abraham; Laufey T. Amundadottir; Jennifer L. Aponte; Adams. Butterworth; Josee Dupuis; Douglas F. Easton; Rosalind A. Eeles; Jeanette Erdmann; Paul W. Franks; Timothy M. Frayling; Torben Hansen; Joanna M. M. Howson; Torben Jørgensen; Jaspal Kooner; Markku Laakso; Claudia Langenberg; Mark I. McCarthy; James S. Pankow; Oluf Pedersen; Elio Riboli; Jerome I. Rotter; Danish Saleheen; Nilesh J. Samani; Heribert Schunkert; Peter Vollenweider; Stephen O'Rahilly; Panos Deloukas; John Danesh; Mark O. Goodarzi; Sekar Kathiresan; James B. Meigs; Margaret G. Ehm; Nicholas J. Wareham; Dawn M. Waterworth

doi:10.1126/scitranslmed.aad3744

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Robert A. Scott, Daniel F. Freitag, Li Li, Audrey Y. Chu, Praveen Surendran, Robin Young, Niels Grarup, Alena Stancakova, Yuning Chen, Tibor V. Varga, Hanieh Yaghootkar, Jian'an Luan, Jing Hua Zhao, Sara M. Willems, Jennifer Wessel, Shuai Wang, Nisa Maruthur, Kyriaki Michailidou, Ailith Pirie, Sven J. van der LeeChristopher Gillson, Ali Amin Al Olama, Philippe Amouyel, Larraitz Arriola, Dominique Arveiler, Iciar Aviles-Olmos, Beverley Balkau, Aurelio Barricarte, Ines Barroso, Sara Benlloch Garcia, Joshua C. Bis, Stefan Blankenberg, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Ingrid B. Borecki, Jette Bork-Jensen, Sarah Bowden, Carlos Caldas, Muriel Caslake, L. Adrienne Cupples, Carlos Cruchaga, Jacek Czajkowski, Marcel den Hoed, Janet A. Dunn, Helena M. Earl, Georg B. Ehret, Ele Ferrannini, Jean Ferrieres, Thomas Foltynie, Ian Ford, Nita G. Forouhi, Francesco Gianfagna, Carlos Gonzalez, Sara Grioni, Louise Hiller, Jan-Hakan Jansson, Marit E. Jørgensen, J. Wouter Jukema, Rudolf Kaaks, Frank Kee, Nicola D. Kerrison, Timothy J. Key, Jukka Kontto, Zsofia Kote-Jarai, Aldi T. Kraja, Kari Kuulasmaa, Johanna Kuusisto, Allan Linneberg, Chunyu Liu, Galle Marenne, Karen L. Mohlke, Andrew P. Morris, Kenneth Muir, Martina Mueller-Nurasyid, Patricia B. Munroe, Carmen Navarro, Sune F. Nielsen, Peter M. Nilsson, Borge G. Nordestgaard, Chris J. Packard, Domenico Palli, Salvatore Panico, Gina M. Peloso, Markus Perola, Annette Peters, Christopher J. Poole, J. Ramn Quiros, Olov Rolandsson, Carlotta Sacerdote, Veikko Salomaa, Mara-Jose Sanchez, Naveed Sattar, Stephen J. Sharp, Rebecca Sims, Nadia Slimani, Jennifer A. Smith, Deborah J. Thompson, Stella Trompet, Rosario Tumino, Daphne L. van der A, Yvonne T. van der Schouw, Jarmo Virtamo, Mark Walker, Klaudia Walter, Jean E. Abraham, Laufey T. Amundadottir, Jennifer L. Aponte, Adams. Butterworth, Josee Dupuis, Douglas F. Easton, Rosalind A. Eeles, Jeanette Erdmann, Paul W. Franks, Timothy M. Frayling, Torben Hansen, Joanna M. M. Howson, Torben Jørgensen, Jaspal Kooner, Markku Laakso, Claudia Langenberg, Mark I. McCarthy, James S. Pankow, Oluf Pedersen, Elio Riboli, Jerome I. Rotter, Danish Saleheen, Nilesh J. Samani, Heribert Schunkert, Peter Vollenweider, Stephen O'Rahilly, Panos Deloukas, John Danesh, Mark O. Goodarzi, Sekar Kathiresan, James B. Meigs, Margaret G. Ehm, Nicholas J. Wareham, Dawn M. Waterworth

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Originalsprog	Engelsk
Artikelnummer	341ra76
Tidsskrift	Science Translational Medicine
Vol/bind	8
Udgave nummer	341
Antal sider	13
ISSN	1946-6234
DOI	https://doi.org/10.1126/scitranslmed.aad3744
Status	Udgivet - 1 jun. 2016

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10.1126/scitranslmed.aad3744

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Scott, R. A., Freitag, D. F., Li, L., Chu, A. Y., Surendran, P., Young, R., Grarup, N., Stancakova, A., Chen, Y., Varga, T. V., Yaghootkar, H., Luan, J., Zhao, J. H., Willems, S. M., Wessel, J., Wang, S., Maruthur, N., Michailidou, K., Pirie, A., ... Waterworth, D. M. (2016). A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Science Translational Medicine, 8(341), [341ra76]. https://doi.org/10.1126/scitranslmed.aad3744

Scott, RA, Freitag, DF, Li, L, Chu, AY, Surendran, P, Young, R, Grarup, N, Stancakova, A, Chen, Y, Varga, TV, Yaghootkar, H, Luan, J, Zhao, JH, Willems, SM, Wessel, J, Wang, S, Maruthur, N, Michailidou, K, Pirie, A, van der Lee, SJ, Gillson, C, Al Olama, AA, Amouyel, P, Arriola, L, Arveiler, D, Aviles-Olmos, I, Balkau, B, Barricarte, A, Barroso, I, Garcia, SB, Bis, JC, Blankenberg, S, Boehnke, M, Boeing, H, Boerwinkle, E, Borecki, IB, Bork-Jensen, J, Bowden, S, Caldas, C, Caslake, M, Cupples, LA, Cruchaga, C, Czajkowski, J, den Hoed, M, Dunn, JA, Earl, HM, Ehret, GB, Ferrannini, E, Ferrieres, J, Foltynie, T, Ford, I, Forouhi, NG, Gianfagna, F, Gonzalez, C, Grioni, S, Hiller, L, Jansson, J-H, Jørgensen, ME, Jukema, JW, Kaaks, R, Kee, F, Kerrison, ND, Key, TJ, Kontto, J, Kote-Jarai, Z, Kraja, AT, Kuulasmaa, K, Kuusisto, J, Linneberg, A, Liu, C, Marenne, G, Mohlke, KL, Morris, AP, Muir, K, Mueller-Nurasyid, M, Munroe, PB, Navarro, C, Nielsen, SF, Nilsson, PM, Nordestgaard, BG, Packard, CJ, Palli, D, Panico, S, Peloso, GM, Perola, M, Peters, A, Poole, CJ, Quiros, JR, Rolandsson, O, Sacerdote, C, Salomaa, V, Sanchez, M-J, Sattar, N, Sharp, SJ, Sims, R, Slimani, N, Smith, JA, Thompson, DJ, Trompet, S, Tumino, R, van der A, DL, van der Schouw, YT, Virtamo, J, Walker, M, Walter, K, Abraham, JE, Amundadottir, LT, Aponte, JL, Butterworth, A, Dupuis, J, Easton, DF, Eeles, RA, Erdmann, J, Franks, PW, Frayling, TM, Hansen, T, Howson, JMM, Jørgensen, T, Kooner, J, Laakso, M, Langenberg, C, McCarthy, MI, Pankow, JS, Pedersen, O, Riboli, E, Rotter, JI, Saleheen, D, Samani, NJ, Schunkert, H, Vollenweider, P, O'Rahilly, S, Deloukas, P, Danesh, J, Goodarzi, MO, Kathiresan, S, Meigs, JB, Ehm, MG, Wareham, NJ & Waterworth, DM 2016, 'A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease', Science Translational Medicine, bind 8, nr. 341, 341ra76. https://doi.org/10.1126/scitranslmed.aad3744

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title = "A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease",

author = "Scott, {Robert A.} and Freitag, {Daniel F.} and Li Li and Chu, {Audrey Y.} and Praveen Surendran and Robin Young and Niels Grarup and Alena Stancakova and Yuning Chen and Varga, {Tibor V.} and Hanieh Yaghootkar and Jian'an Luan and Zhao, {Jing Hua} and Willems, {Sara M.} and Jennifer Wessel and Shuai Wang and Nisa Maruthur and Kyriaki Michailidou and Ailith Pirie and {van der Lee}, {Sven J.} and Christopher Gillson and {Al Olama}, {Ali Amin} and Philippe Amouyel and Larraitz Arriola and Dominique Arveiler and Iciar Aviles-Olmos and Beverley Balkau and Aurelio Barricarte and Ines Barroso and Garcia, {Sara Benlloch} and Bis, {Joshua C.} and Stefan Blankenberg and Michael Boehnke and Heiner Boeing and Eric Boerwinkle and Borecki, {Ingrid B.} and Jette Bork-Jensen and Sarah Bowden and Carlos Caldas and Muriel Caslake and Cupples, {L. Adrienne} and Carlos Cruchaga and Jacek Czajkowski and {den Hoed}, Marcel and Dunn, {Janet A.} and Earl, {Helena M.} and Ehret, {Georg B.} and Ele Ferrannini and Jean Ferrieres and Thomas Foltynie and Ian Ford and Forouhi, {Nita G.} and Francesco Gianfagna and Carlos Gonzalez and Sara Grioni and Louise Hiller and Jan-Hakan Jansson and J{\o}rgensen, {Marit E.} and Jukema, {J. Wouter} and Rudolf Kaaks and Frank Kee and Kerrison, {Nicola D.} and Key, {Timothy J.} and Jukka Kontto and Zsofia Kote-Jarai and Kraja, {Aldi T.} and Kari Kuulasmaa and Johanna Kuusisto and Allan Linneberg and Chunyu Liu and Galle Marenne and Mohlke, {Karen L.} and Morris, {Andrew P.} and Kenneth Muir and Martina Mueller-Nurasyid and Munroe, {Patricia B.} and Carmen Navarro and Nielsen, {Sune F.} and Nilsson, {Peter M.} and Nordestgaard, {Borge G.} and Packard, {Chris J.} and Domenico Palli and Salvatore Panico and Peloso, {Gina M.} and Markus Perola and Annette Peters and Poole, {Christopher J.} and Quiros, {J. Ramn} and Olov Rolandsson and Carlotta Sacerdote and Veikko Salomaa and Mara-Jose Sanchez and Naveed Sattar and Sharp, {Stephen J.} and Rebecca Sims and Nadia Slimani and Smith, {Jennifer A.} and Thompson, {Deborah J.} and Stella Trompet and Rosario Tumino and {van der A}, {Daphne L.} and {van der Schouw}, {Yvonne T.} and Jarmo Virtamo and Mark Walker and Klaudia Walter and Abraham, {Jean E.} and Amundadottir, {Laufey T.} and Aponte, {Jennifer L.} and Adams. Butterworth and Josee Dupuis and Easton, {Douglas F.} and Eeles, {Rosalind A.} and Jeanette Erdmann and Franks, {Paul W.} and Frayling, {Timothy M.} and Torben Hansen and Howson, {Joanna M. M.} and Torben J{\o}rgensen and Jaspal Kooner and Markku Laakso and Claudia Langenberg and McCarthy, {Mark I.} and Pankow, {James S.} and Oluf Pedersen and Elio Riboli and Rotter, {Jerome I.} and Danish Saleheen and Samani, {Nilesh J.} and Heribert Schunkert and Peter Vollenweider and Stephen O'Rahilly and Panos Deloukas and John Danesh and Goodarzi, {Mark O.} and Sekar Kathiresan and Meigs, {James B.} and Ehm, {Margaret G.} and Wareham, {Nicholas J.} and Waterworth, {Dawn M.}",

year = "2016",

month = jun,

day = "1",

doi = "10.1126/scitranslmed.aad3744",

language = "English",

volume = "8",

journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "american association for the advancement of science",

number = "341",

}

TY - JOUR

T1 - A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

AU - Scott, Robert A.

AU - Freitag, Daniel F.

AU - Li, Li

AU - Chu, Audrey Y.

AU - Surendran, Praveen

AU - Young, Robin

AU - Grarup, Niels

AU - Stancakova, Alena

AU - Chen, Yuning

AU - Varga, Tibor V.

AU - Yaghootkar, Hanieh

AU - Luan, Jian'an

AU - Zhao, Jing Hua

AU - Willems, Sara M.

AU - Wessel, Jennifer

AU - Wang, Shuai

AU - Maruthur, Nisa

AU - Michailidou, Kyriaki

AU - Pirie, Ailith

AU - van der Lee, Sven J.

AU - Gillson, Christopher

AU - Al Olama, Ali Amin

AU - Amouyel, Philippe

AU - Arriola, Larraitz

AU - Arveiler, Dominique

AU - Aviles-Olmos, Iciar

AU - Balkau, Beverley

AU - Barricarte, Aurelio

AU - Barroso, Ines

AU - Garcia, Sara Benlloch

AU - Bis, Joshua C.

AU - Blankenberg, Stefan

AU - Boehnke, Michael

AU - Boeing, Heiner

AU - Boerwinkle, Eric

AU - Borecki, Ingrid B.

AU - Bork-Jensen, Jette

AU - Bowden, Sarah

AU - Caldas, Carlos

AU - Caslake, Muriel

AU - Cupples, L. Adrienne

AU - Cruchaga, Carlos

AU - Czajkowski, Jacek

AU - den Hoed, Marcel

AU - Dunn, Janet A.

AU - Earl, Helena M.

AU - Ehret, Georg B.

AU - Ferrannini, Ele

AU - Ferrieres, Jean

AU - Foltynie, Thomas

AU - Ford, Ian

AU - Forouhi, Nita G.

AU - Gianfagna, Francesco

AU - Gonzalez, Carlos

AU - Grioni, Sara

AU - Hiller, Louise

AU - Jansson, Jan-Hakan

AU - Jørgensen, Marit E.

AU - Jukema, J. Wouter

AU - Kaaks, Rudolf

AU - Kee, Frank

AU - Kerrison, Nicola D.

AU - Key, Timothy J.

AU - Kontto, Jukka

AU - Kote-Jarai, Zsofia

AU - Kraja, Aldi T.

AU - Kuulasmaa, Kari

AU - Kuusisto, Johanna

AU - Linneberg, Allan

AU - Liu, Chunyu

AU - Marenne, Galle

AU - Mohlke, Karen L.

AU - Morris, Andrew P.

AU - Muir, Kenneth

AU - Mueller-Nurasyid, Martina

AU - Munroe, Patricia B.

AU - Navarro, Carmen

AU - Nielsen, Sune F.

AU - Nilsson, Peter M.

AU - Nordestgaard, Borge G.

AU - Packard, Chris J.

AU - Palli, Domenico

AU - Panico, Salvatore

AU - Peloso, Gina M.

AU - Perola, Markus

AU - Peters, Annette

AU - Poole, Christopher J.

AU - Quiros, J. Ramn

AU - Rolandsson, Olov

AU - Sacerdote, Carlotta

AU - Salomaa, Veikko

AU - Sanchez, Mara-Jose

AU - Sattar, Naveed

AU - Sharp, Stephen J.

AU - Sims, Rebecca

AU - Slimani, Nadia

AU - Smith, Jennifer A.

AU - Thompson, Deborah J.

AU - Trompet, Stella

AU - Tumino, Rosario

AU - van der A, Daphne L.

AU - van der Schouw, Yvonne T.

AU - Virtamo, Jarmo

AU - Walker, Mark

AU - Walter, Klaudia

AU - Abraham, Jean E.

AU - Amundadottir, Laufey T.

AU - Aponte, Jennifer L.

AU - Butterworth, Adams.

AU - Dupuis, Josee

AU - Easton, Douglas F.

AU - Eeles, Rosalind A.

AU - Erdmann, Jeanette

AU - Franks, Paul W.

AU - Frayling, Timothy M.

AU - Hansen, Torben

AU - Howson, Joanna M. M.

AU - Jørgensen, Torben

AU - Kooner, Jaspal

AU - Laakso, Markku

AU - Langenberg, Claudia

AU - McCarthy, Mark I.

AU - Pankow, James S.

AU - Pedersen, Oluf

AU - Riboli, Elio

AU - Rotter, Jerome I.

AU - Saleheen, Danish

AU - Samani, Nilesh J.

AU - Schunkert, Heribert

AU - Vollenweider, Peter

AU - O'Rahilly, Stephen

AU - Deloukas, Panos

AU - Danesh, John

AU - Goodarzi, Mark O.

AU - Kathiresan, Sekar

AU - Meigs, James B.

AU - Ehm, Margaret G.

AU - Wareham, Nicholas J.

AU - Waterworth, Dawn M.

PY - 2016/6/1

Y1 - 2016/6/1

U2 - 10.1126/scitranslmed.aad3744

DO - 10.1126/scitranslmed.aad3744

M3 - Journal article

C2 - 27252175

SN - 1946-6234

VL - 8

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 341

M1 - 341ra76

ER -

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

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