@article{d599fb809a8111dd86a6000ea68e967b,
title = "1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice.",
abstract = "Adult-type hypolactasia is a genetic condition making approximately one half of the human population intolerant to milk because of abdominal symptoms. The cause is a post-weaning down-regulation of the intestinal-specific enzyme lactase-phlorizin hydrolase (LPH) reducing the intestinal capacity to hydrolyze lactose. We here demonstrate that the stretch -17 to -994 in the pig LPH-promoter carries cis-elements which direct a small intestinal-specific expression and a post-weaning decline of a linked rabbit beta-globin gene. These data demonstrate that the post-weaning decline of LPH is mainly due to a transcriptional down-regulation.",
author = "Troelsen, {J T} and A Mehlum and N Spodsberg and H Prydz and O Nor{\'e}n and H Sj{\"o}str{\"o}m and J{\o}rgen Olsen and Hansen, {Gert Helge}",
note = "Keywords: Age Factors; Animals; Gene Expression Regulation; Glycosylceramidase; Intestine, Small; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Promoter Regions (Genetics); RNA, Messenger; Tissue Distribution; Transcription, Genetic",
year = "1994",
doi = "10.1016/0014-5793(94)80519-9",
language = "English",
volume = "342",
pages = "291--6",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "3",
}