Billede af Nikos Sidiropoulos

Nikos Sidiropoulos

 https://orcid.org/0000-0002-1854-1193
20152019

Publikationer pr. år

Personlig profil

Primære forskningsområder

Chromatin Architecture, Structural Variants, Cancer Genomics, Visualization, Bioinformatics

 

Aktuel forskning

Cancer is caused by the accumulation of genomic structural variants (SVs), such as deletions and translocations, that cause uncontrolled cell growth, and accumulation of SVs are associated with aggressive cancers. SVs can affect up to hundreds of genes and can be used as robust biomarkers for earlier diagnosis and more precise prognosis. However, we have only rudimentary knowledge of why certain regions are more prone to form SVs, and how SVs affect gene regulation, such as activation of oncogenes. A better understanding of the causes and consequences of SVs has therefore important implications for improving diagnosis and treatment.

Previous work has shown that genomic proximity can be used to identify where SVs form, but this has not been done on a genome-wide scale, which is what we aim to investigate in this project. We have prepared and generated next-generation sequencing data from a phylogeny of cancer cells with acquired SVs, which provide a unique system to examine the interplay between long-range interactions and SV formation in cancer.

The current project will develop and apply novel next-generation sequencing-based methods to cancer cells to answer the question, why certain regions are more prone to form SVs such as fusion genes. We aim to identify the impact of long-range interactions on SV formation and gene regulation in cancer, with important implications for improving the understanding and utility of clinically relevant SVs.

 

Ekspertise relateret til FN’s Verdensmål

I 2015 blev FN-landende enige om 17 Verdensmål til at standse fattigdom, beskytte planeten og sikre velstand for alle. Denne persons arbejde bidrager til følgende verdensmål:

  • Verdensmål 3 - Sundhed og trivsel

Uddannelse (Akademiske kvalifikationer)

University of Copenhagen

Dimissionsdato: 5 maj 2015

Aristotle University of Thessaloniki

Dimissionsdato: 14 jul. 2011

Fingeraftryk

Dyk ned i forskningsemnerne, hvor Nikos Sidiropoulos er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
  • 6 Lignende profiler
Se fuldt fingerprint
  • 5 Tidsskriftartikel
  • 1 Bidrag til bog/antologi

  • The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

    Ge, Y., Schuster, M. B., Pundhir, S., Rapin, N., Bagger, F. O., Sidiropoulos, N., Hashem, N. & Porse, B. T., 1 dec. 2019, I: Nature Communications. 10, 1, 14 s., 172.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

    7 Citationer (Scopus)
    57 Downloads (Pure)

  • Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories

    Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., Heckmann, D., Sidiropoulos, N., Waszak, S. M., Hübschmann, D., Urbanucci, A., Girma, E. G., Kuryshev, V., Klimczak, L. J., Saini, N., Stütz, A. M., Weichenhan, D., Böttcher, L. M., Toth, R., Hendriksen, J. D., & 35 flereKoop, C., Lutsik, P., Matzk, S., Warnatz, H. J., Amstislavskiy, V., Feuerstein, C., Raeder, B., Bogatyrova, O., Schmitz, E. M., Hube-Magg, C., Kluth, M., Huland, H., Graefen, M., Lawerenz, C., Henry, G. H., Yamaguchi, T. N., Malewska, A., Meiners, J., Schilling, D., Reisinger, E., Eils, R., Schlesner, M., Strand, D. W., Bristow, R. G., Boutros, P. C., von Kalle, C., Gordenin, D., Sültmann, H., Brors, B., Sauter, G., Plass, C., Yaspo, M. L., Korbel, J. O., Schlomm, T. & Weischenfeldt, J., 2018, I: Cancer Cell. 34, 6, s. 996-1011.e8 24 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

    60 Citationer (Scopus)

  • SinaPlot: an enhanced chart for simple and truthful representation of single observations over multiple classes

    Sidiropoulos, N., Sohi, S. H., Pedersen, T. L., Porse, B. T., Winther, O., Rapin, N. & Bagger, F. O., 3 jul. 2018, I: Journal of Computational and Graphical Statistics. 27, 3, s. 673-676 4 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

    12 Citationer (Scopus)

  • Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types

    Ecker, S., Chen, L., Pancaldi, V., Bagger, F. O., Fernández, J. M., Carrillo de Santa Pau, E., Juan, D., Mann, A. L., Watt, S., Casale, F. P., Sidiropoulos, N., Rapin, N. P. J-P., Merkel, A., Stunnenberg, H. G., Stegle, O., Frontini, M., Downes, K., Pastinen, T., Kuijpers, T. W., Rico, D., & 50 flereValencia, A., Beck, S., Soranzo, N., Paul, D. S., Albers, C. A., Amstislavskiy, V., Ashford, S., Bomba, L., Bujold, D., Burden, F., Busche, S., Caron, M., Chen, S-H., Cheung, W. A., Clarke, L., Colgiu, I., Datta, A., Delaneau, O., Elding, H., Farrow, S., Garrido-Martín, D., Ge, B., Guigo, R., Iotchkova, V., Kundu, K., Kwan, T., Lambourne, J. J., Lowy, E., Mead, D., Pourfarzad, F., Redensek, A., Rehnstrom, K., Rendon, A., Richardson, D. M., Risch, T., Rowlston, S., Shao, X., Simon, M. M., Sultan, M., Walter, K., Wilder, S. P., Yan, Y., Antonarakis, S. E., Bourque, G., Dermitzakis, E. T., Flicek, P., Lehrach, H., Martens, J. H. A., Yaspo, M-L. & Ouwehand, W. H., 26 jan. 2017, I: Genome Biology. 18, 1, 17 s., 18.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

    48 Citationer (Scopus)
    151 Downloads (Pure)

  • The whole-genome landscape of medulloblastoma subtypes

    Northcott, P. A., Buchhalter, I., Morrissy, A. S., Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., Warnatz, H. J., Sidiropoulos, N., Phillips, A. H., Schumacher, S., Kleinheinz, K., Waszak, S. M., Erkek, S., Jones, D. T. W., Worst, B. C., Kool, M., & 67 flereZapatka, M., Jäger, N., Chavez, L., Hutter, B., Bieg, M., Paramasivam, N., Heinold, M., Gu, Z., Ishaque, N., Jäger-Schmidt, C., Imbusch, C. D., Jugold, A., Hübschmann, D., Risch, T., Amstislavskiy, V., Gonzalez, F. G. R., Weber, U. D., Wolf, S., Robinson, G. W., Zhou, X., Wu, G., Finkelstein, D., Liu, Y., Cavalli, F. M. G., Luu, B., Ramaswamy, V., Wu, X., Koster, J., Ryzhova, M., Cho, Y. J., Pomeroy, S. L., Herold-Mende, C., Schuhmann, M., Ebinger, M., Liau, L. M., Mora, J., McLendon, R. E., Jabado, N., Kumabe, T., Chuah, E., Ma, Y., Moore, R. A., Mungall, A. J., Mungall, K. L., Thiessen, N., Tse, K., Wong, T., Jones, S. J. M., Witt, O., Milde, T., Von Deimling, A., Capper, D., Korshunov, A., Yaspo, M. L., Kriwacki, R., Gajjar, A., Zhang, J., Beroukhim, R., Fraenkel, E., Korbel, J. O., Brors, B., Schlesner, M., Eils, R., Marra, M. A., Pfister, S. M., Taylor, M. D. & Lichter, P., 19 jul. 2017, I: Nature. 547, 7663, s. 311-317 7 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

    342 Citationer (Scopus)
    175 Downloads (Pure)

  • Reproducible analysis of sequencing-based RNA structure probing data with user-friendly tools

    Kielpinski, L. J., Sidiropoulos, N. & Vinther, J., 2015, Structures of large RNA molecules and their complexes. Woodson, S. A. & Allain, F. H. T. (red.). Elsevier, s. 153-180 28 s. (Methods in Enzymology, Bind 558).

    Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

    7 Citationer (Scopus)