Karl Mattias Rickhag

Kort præsentation

2015-               Assistant Professor in Neuropharmacology at Molecular Neuropharmacology Laboratory, Dept. of Neuroscience and Pharmacology, Univ. of Copenhagen,

2010-2015       Post-doctoral fellow (individual 3-year grant from the Lundbeck Foundation), Molecular Neuropharmacology Laboratory, University of Copenhagen, Denmark

2008-2010       Post-doctoral fellow (individual 3-year grant from the Danish Research Council, FSS), Molecular Neuropharmacology Laboratory, University of Copenhagen, Denmark

2007                Post-doctoral fellow at Laboratory for Experimental Brain Research,Lund University, Sweden

2007                PhD in Neuroscience at Lund University (24th February). Thesis title:”Gene Expression Changes and Brain Plasticity after Experimental Stroke”. Supervisor: Prof. Tadeusz Wieloch

2003-2007       PhD-student in neuroscience at Laboratory for Experimental Brain Research, Lund University, Sweden

1998-2002       Masters in Biomedical Science, four-year undergraduate program, Lund University, Sweden

1997-1998         Military service in the Swedish Air Force

1993-1997          Senior High School in biological sciences, Vetlanda, Sweden

i) Co-supervision of three master students and two bachelor students at Molecular Neuropharmacology Laboratory, University of Copenhagen. Supervision involved both theoretical as well as experimental guidance within neuropharmacology, histology and in vivo models.

ii) Co-supervisor for PhD student Annika Thomsen (enrolled in April 2014) at Molecular Neuropharmacology Laboratory, University of Copenhagen headed by Prof. Gether.

iii) Daily supervision of laboratory technicians for more than six years.

iv) Submission of all animal license applications to the Danish Animal Inspectorate Agency and Danish Working Environment Authority at Molecular Neuropharmacology Laboratory, University of Copenhagen.

v)Management and responsibility for genetically modified mouse lines (approximately ten different mouse lines) at Molecular Neuropharmacology Laboratory, University of Copenhagen.

- In vivo

Mouse genetics, transcardial perfusion, drug administration (subcutaneous, intraperitoneal, intravenous), SHIRPA screen, assessment of locomotion and psychostimulant-induced hyperlocomotion, sensitization, sensori-motor function tests (rotating pole test, cylinder test), and animal breeding

- Virus mediated expression techniques in vivo

Expression of genetically reengineered receptors (G protein coupled receptors or ligand-gated ion channels) activated by synthetic ligands

- Histology

Immunohistochemistry/-cytochemistry, fresh/frozen tissue section preparations using cryostat and vibratome, acute brain slice preparations, staining techniques, in situ hybridization

- Molecular biology 

In situ hybridization, PCR, RNA extraction, quantitative real-time PCR, genotyping, microarrays

- Pharmacology

Competitive binding assays to assess binding affinity and binding sites, saturation binding and uptake assays, autoradiography

- Biochemistry

SDS-PAGE/immunoblotting,immunoprecipitation, co-immunoprecipitation, surface biotinylation, synaptosomal preparations,andcell trafficking assays

- Additional experience

Fluorescence activated cell sorting (FACS) of dopaminergic neurons, confocal/light microscopy, lentiviral transduction

Attendee/presenter of scientific data during the following conferences:

• Dopamine 2013, Alghero, Italy (2013)

• 43^th Annual Meeting for Society of Neuroscience, San Diego, USA (2013)

• Membrane Transport Proteins, Les Diablerets, Switzerland, July (2012)

• 41^th Annual Meeting for Society of Neuroscience, Washington DC, USA (2011)

• 40^th Annual Meeting for Society of    Neuroscience, San Diego, USA (2010)

• Membrane Transport Proteins, Biddeford, USA (2010)

• 39^th Annual Meeting for Society of    Neuroscience, Chicago, USA (2009)

• 38^th Annual Meeting for Society of    Neuroscience, Washington DC, USA (2008)

• 35^th Annual Meeting for Society of    Neuroscience, Washington DC, USA (2005)

• 34^th Annual Meeting for Society of Neuroscience, San Diego, USA (2004)

   

  Invited speaker at the following conference:

• Molecular Imaging in Medical Research, Greifswald, Germany (2012)

• World Pharma 2010:Bridging Basic and Clinical Pharmacology, Copenhagen, Denmark (2010)

• 3^rd Scandinavian conference on Molecular Physiology of Channels and Transporters, Sigtuna, Sweden, (2010)

  Visiting scientist at the following research group:

• Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada. Invitation by Professor Louis-Eric Trudeau (in April 2014)

• AGY Therapeutics Inc., San Francisco, USA (for two weeks during 2003) 

   

Language skills

Proficiency in written and spoken English. Some experience in German and French.

Microsoft Office (Word, Excel, PowerPoint), Adobe Illustrator, Adobe Photoshop,

Adobe Acrobat Reader, ImageJ and GraphPad (for statistical analysis).

Co-inventor for the rights to ”Sigma ligands for neuronal regeneration and functional recovery (Filed patent to US Patent and Trademark Office) January 27th, 2005.