Kort præsentation

Eric P. Bennett has obtained both his master degree in Biochemistry and Molecular Biology (MSc) and doctoral degree (Dr Med) from the University of Copenhagen. His research efforts at the Copenhagen Center for Glycomics, University of Copenhagen, have been concentrated in the field of Glycobiology where he 2 decades ago cloned and identified more than 30 human glycosyltransferase encoded genes (glycogenes).

For the last 9 years his efforts have been focused on ways of establishing precision-engineered isogenic cells lacking individual glycogenes. Using the recently emerged nuclease targeting technologies, such as ZFN, TALEN and CRISPR/Cas9 these efforts have among others led to establishment of novel methodologies that both improve the targeting and indel detection efficacy of precise gene targeting.

The methods and principles developed show great translational potential into the biotech and therapeutic genome targeting space.

CV

Education:   

1990: MSc/Cand. scient./Biochemistry, Science Faculty, University of Copenhagen, Denmark

2012: DSc/Dr.med., Faculty of Health Science, University of Copenhagen, Denmark

Title of dissertation:

Doctor of Medicine (Dr.med) thesis entitled; “Control of Mucin-Type O-Glycosylation – A Classification of the Polypeptide GalNAc-transferase Gene Family”. Published in revised form in; Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA. Glycobiology. 2012 Jun;22(6):736-56., with continued +421 citations and with 90 citations in 2018

Academic appointments:

1990-1990: Research fellow, The Biomembrane Institute, Seattle , USA.

1990-2000: Research assistant professor, University of Copenhagen, Department of Odontology

2000-2004: Research associated professor, University of Copenhagen, Department of Odontology

2004-       : Associated professor, University of Copenhagen, Department of Odontology

Administrative functions:

2004-2008: Board member, Copenhagen Cell- and Tissue Biology Postgraduate School

2005-2009: Steering committee, the Cell Biology Cluster, University of Copenhagen

2006-2012: Chairman, the Working Environment Organization (AMO), Department of Odontology

2007-       : Member, the Working Environment Committee (FAMU), Health Science Faculty

2017-       : Member, Health Science Faculty Innovation Work Group

2019-       : Board member, Graduate Programme for Oral Sciences, Forensic Medicine and                    Bioanthropology

Societies:

Member of Danish Society for Biochemistry and Molecular Biology (since 1990- )

Society for theoretical and applied therapy (since 2012- )

Board member of Danish Society for Biotechnology (Since 2015- )

Member of Mercks European CRISPR Core Partnership, (since 2015- )

NIST (National Institute of Science and Technology) Genome editing Consortium, USA (since 2019- )

Consultancies:

2000-2007: ZymeQuest, Boston, USA

2016        : GlycoDisplay Aps

2017        : CoboTechnologies Aps

Companies:

1999: Glycozyme Aps, co-founder

2015: GeCo Aps, founder

2016: GlycoDisplay Aps, co-founder

2017: CoboTechnologies Aps, co-founder

Prizes:

Dannin Prize, 2016

Supervision

Supervised or co-supervised multiple PhD-, Bachelor- and Master -students (>20)

Technician training supervision of multiple technicians (>6)

Leadership in Science:

Impact: Google Scholar Citations 2019: H-index 49, 2014: H-index 35, Total citations:8802, citations since 2014:4043.

Interesseområder

Conferences and Presentations

2019

Invited speaker: Invited speaker at 5th Precision CRISPR Genome Editing Congress, Boston, USA, 22-23^rd of May, 2019

Invited Speaker: COETUS pre-graduate seminar, Holst Aud, Mærsk, 8/5, 2019; “The CRISPR Craze: A Gene Therapy ”Dream” come through?”

Invited speaker: Therapeutic genome editing congress, Boston, USA, 22-23^rd of March, 2019

Invited speaker: Nordea Markets, Copenhagen: 8/3, 2019: “The CRISPR Craze: A Gene Therapy ”Dream” come through?”

2018

Invited lecture: The NovoNordiskFonden’s Copenhagen Bioscience event; “Talking about CRISPR”, , 5^th of April, 2018, at Mærsk Tower, Panum: “Design, Deliver & Detect”: Considerations for optimized CRISPR Applications and Workflows

Invited lecture: OxfordGlobals, 2^nd Genome Editing USA Congress May 10^th-11^th, Boston: “Design, Deliver & Detect: Considerations for optimized in vitro and ex vivo CRISPR applications.

Poster presentation: CRISPR 2018 Meeting in Vilnius, June 20-23, Vilnius, Lithuania,: “Cellular Indel Profiles and Dynamics induced by different CRISPR/Cas9 Delivery Formats: Applying in vitro Methodologies ex vivo”

Invited speaker: Genome editing (CRISPR/Cas9) in drug discovery, Basel, 13 September 2018:”Cellular indel profiles and dynamics induced by different CRISPR/Cas9 delivery formats: Applying in vitro methodologies ex vivo”

Invited speaker: Dansk Selskab for Klinisk Immunologi og Dansk Hæmatologisk Selskab, CRISPR/Cas9, Odense, 26. september, 2018; ”Cellular Indel Profiles and Dynamics induced by different CRISPR/Cas9 delivery formats: Applying in vitro methodologies ex vivo”

Invited speaker: 3rd Precision CRISPR: Drug Discovery & Gene Therapy 2018, London 22-24^th of October, 2018; “Detection of in vitro and ex vivo Cellular indel Profiles and Dynamics Induced By Different CRISPR/Cas9 Delivery Formats”

Invited speaker: The EMBO Basel Life meeting on CRISPR/Cas9 in drug discovery, Basel, 13th of September, 2018: “Cellular Indel outcomes and dynamics induced by different CRISPR/Cas9 delivery formats”

Invited speaker: ”CRISPR/Cas9”: Dansk Selskab for Klinisk Immunologi og Dansk Hæmatologisk Selskab inviterer til videnskabeligt møde, den 26. september 2018 kl. 14.00-17.30

Invited speaker: HansonWade, Precision CRISPR: Drug Discovery & Gene Therapy Congress, , London, 22-24 October, 2018: “Detection of in vitro and ex vivo Cellular indel Profiles and Dynamics induced by different CRISPR/Cas9 delivery formats

Invited speaker:  Oxford Globals 4th Annual Genome Editing Congress, 8-9 November 2018, London, UK: “Cellular Indel outcomes and dynamics induced by different CRISPR/Cas9 delivery formats”

Invited speaker: Gene Editing Congress – 4Bio Summit – 27th-28th November 2018, Rotterdam, The Netherlands “Cellular indel outcomes and dynamics induced by different CRISPR/Cas9 delivery formats”

Invited seminar, hosted by Gerald Schwank, ETH Zurich, Switzerland: “Genome Editing induced Indel Detection”, December 11^th, 2018

2017

Invited seminar: Host Matthew Porteus, Stanford, 14/2. “Indel detection by Amplicon Analysis (IDAA^TM): A paradigm shift in precise genome targeting induced indel detection”

Invited seminar: Host Jon Chesnut, Thermo Fisher Scientific,17/2. “Indel detection by Amplicon Analysis (IDAA^TM): A paradigm shift in precise genome targeting induced indel detection”

Invited speaker: Copenhagen Workshop on Injectables, 23 March 2017, Haderup Auditorium, Panum Institute. “Glycooptimization of biopharmaceutical injectables”

Invited seminar: Host Emmanouil Metzacopian, Cambridge, 20^th of June, Sanger Institute,, “A Programmable Nuclease Story of two Tales: Absolute Indel Quantification and Inducible Gene-Expression”

Invited speaker: 14th International Workshop on Carcinoma-associated Mucins, Robinson College, Cambridge, 24^th of July. “Precise integration of inducible transcriptional elements (PrIITE) enables identification of CDX2 as a mucin “locus control” gene”.

Invited speaker: CRISPR Precision Genome Editing Congress Europe/hansonwade, Mercure conference hotel, Berlin, November 13^th-14^th, 2017

Invited speaker: VIB Training 'Genome Editing: CRISPR Design & Strategy' - Ghent, 21 Nov. 17, Marriott, Gehnt

Invited speaker: Copenhagen Bioscience Lecture; The Future Design of Life, Novo Nordisk Fonden, December 7^th, 2017

2016

Invited speaker: Pre-meeting workshop:“Innovative Approaches to Characterise the Specificity of CRISPR/ Cas9 Systems”. Sheraton Brussels Airport Hotel, Sheraton Brussels Airport Hotel, Belgium

Invited speaker: Genome Editing Applications, 3rd-4^th February 2016, Sheraton Brussels Airport Hotel, Belgium 3/2-2016, session chair and opening Remarks. Invited speaker: “Improved Strategies for Identifying the Breaks in a Precisely Broken Genome”

Invited speaker: University of California, San Diego, USA, 17/2-2016, Invited special seminar, Hosted by Ajit Varki: “Engineered genome editing tools for glycogene activation and inactivation: "On/off” switches for glycogene function”.

Invited speaker: Genome Editing & Engineering Conference on 18 - 19 February 2016 in San Diego, CA, USA: "Hit and seek: Improved targeting and indel identification methodologies for genome editing".

Invited speaker: Astra Zeneca, Mølndal, Gothenburg, Sweden: “Improved Strategies for Identifying the Breaks in a Precisely Broken Genome”

Invited speaker: Genome Editing & Gene Modulation Congress 2016, 6-8^th of April, St Hilda’s College, Oxford, UK: “Hit and seek: Improved Strategies for Identifying the Breaks in a Precisely Broken Genome”.

Invited speaker: Biokemisk Forening symposium, “CRISPR genome editng”, Panum, Denmark, 22^nd-23^rd of September, 2016: “Hit and seek: Finding the breaks in a precisely broken genome”

Invited speaker: European Health Science Match 2016, September 26^th, De, 2016: “Solving an unmet Genome Editing Need: Fast, Accurate and Robust Indel Detection by Amplicon Analysis (IDAA)”. Heidelberg, De.

Invited speaker: 27th Joint Glycobiology Meeting, 16-18th of October, Nijmegen, The Netherlands: “Mucin-type O-glycosylation: Biosynthetic aspects in relation to function and disease”.

Invited speaker: Lectureship event, sponsored by IDA Biotechnology and Danish Biological Society, DTU Lyngby, 23/11, 2016: "Detection of indel induced by CRISPR/Cas9"

Invited speaker: Janssen Pharmaceutica,NV, Beerse, Begium, 27-28/10, 2016: “Solving an unmet Genome Editing Need: Fast, Accurate and Robust Indel Detection by Amplicon Analysis (IDAA)”.

Invited speaker: 2nd Annual Genome Editing Congress, London, UK, 10 – 11 November, 2016:  “Indel Profiles And Dynamics Of CRISPR/Cas Delivery Systems In Mammalian Cells”.

Invited speaker: 6th Munich Biomarker Conference" on November 29th – 30th, 2016 in Munich, Germany: " Indel detection: The “achilles heel” of precise genome targeting“.

Invited speaker, Keynote: 1st NovoNordisk CRISPR Symposium, December 16th, 2016, Måløv, Denmark: "Solving an unmet need in genome targeting: fast, precise and efficient indel detection by amplicon analysis”.

2015

Invited lecture: Sigma-Aldrich Exclusive CRISPR core partnership meeting, Lake Como, It, 5-6th of May: ”Fast and Sensitive Detection of Indels Induced by Precise Gene Targeting”,

Invited seminar: IPATIMUP Seminar , 3/6-2015, O’porto, P: “Improved targeting and indel identification methodologies for genome editing”

Invited lecture: 13th International Workshop on Carcinoma-associated Mucins, Robinson College, Cambridge, UK, 18th – 22nd July 2015:“Improved targeting and indel identification methodologies for genome editing”

 Invited lecture: Polymorfien/SSI, Dk, 27/10-2015: “Hit and Seek”: Improved Strategies for Precise Genome Editing Induced Indel Identification

Invited lecture: Royal Holloway Genome Editing Symposium, Gb, 11^th November 2015, 1:30-5:30 pm: “Novel Improved Targeting and Indel Identification Methodologies for Genome Editing”

Invited lecture: Genome Editing Congress, 12th & 13th November 2015, Novotel London West, London: “Novel Improved targeting and indel identification methodologies for genome editing” 

2014

Invited lecture: Novo Nordisk, Måløv, tirsdag den 22-Apr-2014 kl 13:“Gene targeting in mammalian cells: Available tools,,,,and more”

Invited lecture: Dansk Bioteknologisk Selskab, Munkebjerg, Vejle, 22/5-23/5, 2014: ”Efficient precise glycoengineering of cellular post translational modification pathways”

Invited lecture: GlycoT, O’Porto, P, 18/6-21/6, 2014: “GlyMAP: A Glycogene Mutation Map For Discovery of Diseases of Glycosylation”

Invited lecture: CHO Retreat: Synergies and collaboration, Konventum/Helsingør August 28^th-29^th, 2014:” Exploreing opportunities for glycoengineering CHO cells with designed glycosylation capacity”

Invited lecture: Honolulu, HI - Joint Meeting of the Society for Glycobiology and the Japanese Society for Carbohydrate Research, 16/11-19/11, 2014: “Probing glycan functions by precise gene editing”

Invited lecture: Basic and Clinical Research in Musculo-Skeletal and Oral Sciences, Annual Symposium 2014, Borupgaard, Snekkersten, 11/12-12/12, 2014: “The role of glycans in phosphate homeostasis and skeletal mineralization: “Glycans are in control”

Seminar, symposia and PhD-course organization

2019

Co-Organizer of the 14. Danish Conference on Biotechnology and Molecular Biology, May 28th -29th, 2019, Hotel Munkebjerg, Vejle, “ Therapeutic Proteins”

Organizer: International Ph.D Course in Glycobiology, Mærsk Tower/Panum&Lund, May 6th –10th, 2019

2018

Co-Organizer of the 13. Danish Conference on Biotechnology and Molecular Biology, May30th - June 1^st, 2018, Hotel Munkebjerg, Vejle, “ Big data”

Co-organizer: PhD course: “Genome Editing using CRISPR/Cas9”, December 4^th-6^th, 2018,

Co-organizer: Mini-symposium: “Genome Editing using CRISPR/Cas9”, December 7th, 2018; >110 registered participants

2017

Organizer: Mini-seminar Series on Gene Editing and CRISPR, 30/5-2017, Kenote invites; Matthew Porteus (Stanford, USA), Mark Behlke (IDT, USA), Jacob Giehm (Århus Universitet); >100 registered participants

Co-Organizer of the 12. Danish Conference on Biotechnology and Molecular Biology, June 1^st- 2^nd, 2017, Hotel Munkebjerg, Vejle, “CRISPR based technologies and bio-products”, >110 registered participants. EP Bennett, Round table discussion facilitator: CRISPR based technologies: impact on society, ethics and regulation. Debaters:  Gorm Greisen, Birger Lindberg Møller, Matthew Porteus, Philip Webber, Inga Nørby.

Co-organizer: 2 week international Ph.D Course in “Gene Targeting”, Panum August 14th –25th, 2017

Co-organizer: Mini-symposium precise Genome Editing”, Panum, Augsut 24^th-25^th, 2017; >110 registered participants

2016

Co-organizer: MoMeD PhD course: “Genome editing using CRISPR/Cas9”, BRIC, October 25^th-27^th. 2016

Co-organizer: International Ph.D Course in Glycobiology, Panum/Lund, October 10th –14th, 2016

Co-organizer: 11th Danish Conference on Biotechnology and Molecular Biology, May 26 – 27, 2016, Hotel Munkebjerg, Vejle, “Glycobiology and Carbohydrate Biotechnology”

2015

Co-organizer: 2 week PhD-Course “Gene Targeting”, 2015, University of Copenhagen.

Co-organizer: Mini Symposium: “Precise Genome Editing Technologies”, 2015, University of Copenhagen.>120 registered participants

2014

Co-organizer: Mini Symposium: “Precise Genome Editing Technologies”, Panum, Faculty Club, 31st of October, 2014, >120 registered participants

2013

Co-organizer: 2 week Ph.D Course in “Gene Targeting “, course leader. 

Co-organizer: Mini Symposium, “Precise Genome Editing Technologies”, Panum, 19th-20th of September, 2013

2012

Co-organizer: 1 week international Ph.D. kursus in “Glycobiology” (courseleader)

Undervisnings- og vejledningsområder

Outreach/press activities

2018:

Ingeniøren, interview: Crispr-forsker: Vigtigt at få undersøgt mulige bivirkninger ved Crispr, https://ing.dk/artikel/crispr-forsker-vigtigt-at-undersoege-mulige-bivirkninger-ved-crispr-211678, 12. april, 2018

BioVox interview: “How CRISPR/Cas9 is improving drug development using zebrafish”, https://biovox.eu/insights/detail/how-crispr-cas9-is-improving-drug-development-using-zebrafish, Tuesday 4 September 2018

 Live webinar: OxfordGlobal Live Genome Editing Webinars and Q&A Sessions, Thursday 20th September, 2018

National TV:

DR2Dagen live interview, 21/9-2018 over temaet: ”Dommedagsmyg slippes ud i Burkina Faso”

Panel hearing/discussion: “Conversations on Science, Regulation, and Society - the Future of Genome Editing in European healthcare systems”, 16 October 2018, 17:00 - 19:30 Brussels, Belgium, European Parliament

2017:

National TV:

DR2Dagen, 211217, live nyhedsinterview, ”Nyt banebrydene forsøg med genterapi”

Outreach/electronic:

UCPH Health Science News (17.02.2017), Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis

 UCPH Health Science News (08.05.2017), Vigtige Skridt mod fremtidens genmedicin

Frontline Genomics. November Press release, commentary EP Bennett: “Collaboration Copenhagen/DesktopGenetics to analyse a novel crispr assay” (http://www.frontlinegenomics.com/news/17654/collaboration-copenhagen-desktop-genetics-analyse-novel-crispr-assay/)

 GenomeWeb. November press release, commentary EP Bennett: “Collaboration Copenhagen/DesktopGenetics to analyse a novel crispr assay”. (https://www.genomeweb.com/business-news/copenhagen-center-glycomics-desktop-genetics-team-crispr-analysis-assay)

Technology Networks, November press release, commentary EP Bennett: “Collaboration Copenhagen/DesktopGenetics to analyse a novel crispr assay”.  , (https://www.technologynetworks.com/genomics/news/copenhagen-center-for-glycomics-collaborates-with-desktop-genetics-to-analyze-their-novel-crispr-295610)

2016:

National TV:

TV2News, 27/4-2016, 2x4min live interview om etik og genome editering

Outreach/electronic

Live Webinar Oxford Global Genome Editing Webinar, 15^th September:, Genome Editing UK: “A Genome Editing Pipeline for Cell Line Engineering based on IDAA and FACS”