Yeast as a model system to study RecQ helicase function

TY - JOUR

T1 - Yeast as a model system to study RecQ helicase function

AU - Ashton, Thomas M

AU - Hickson, Ian David

N1 - Keywords: Animals; DNA Breaks, Double-Stranded; DNA Helicases; DNA Repair; DNA, Fungal; Humans; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins

PY - 2010/3/2

Y1 - 2010/3/2

N2 - Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1+, respectively. Studies in these yeast species have revealed a plethora of roles for the Sgs1 and Rqh1 proteins in repair of double strand breaks, restart of stalled replication forks, processing of aberrant intermediates that arise during meiotic recombination, and maintenance of telomeres. In this review, we focus on the known roles of Sgs1 and Rqh1 and how studies in yeast species have improved our knowledge of how BLM suppresses neoplastic transformation.

AB - Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1+, respectively. Studies in these yeast species have revealed a plethora of roles for the Sgs1 and Rqh1 proteins in repair of double strand breaks, restart of stalled replication forks, processing of aberrant intermediates that arise during meiotic recombination, and maintenance of telomeres. In this review, we focus on the known roles of Sgs1 and Rqh1 and how studies in yeast species have improved our knowledge of how BLM suppresses neoplastic transformation.

U2 - 10.1016/j.dnarep.2009.12.007

DO - 10.1016/j.dnarep.2009.12.007

M3 - Review

C2 - 20071248

SN - 1568-7864

VL - 9

SP - 303

EP - 314

JO - DNA Repair

JF - DNA Repair

IS - 3

ER -