Abstract
The emergence of the H1N1 swine flu pandemic has the possibility to develop the occurrence of disaster- or drug-resistant viruses by additional reassortments in novel influenza A virus. In the course of an anti-influenza screening program for natural products, 10 xanthone derivatives (1-10) were isolated by bioassay-guided fractionation from the EtOAc-soluble extract of Polygala karensium. Compounds 1, 3, 5, 7, and 9 with a hydroxy group at C-1 showed strong inhibitory effects on neuraminidases from various influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, these compounds reduced the cytopathic effect of H1N1 swine influenza virus in MDCK cells. Our results suggest that xanthones from P. karensium may be useful in the prevention and treatment of disease by influenza viruses.
| Original language | English |
|---|---|
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 22 |
| Issue number | 11 |
| Pages (from-to) | 3688-92 |
| Number of pages | 5 |
| ISSN | 0960-894X |
| DOIs | |
| Publication status | Published - 1 Jun 2012 |
Keywords
- Animals
- Antiviral Agents
- Cell Line
- Dogs
- Drug Resistance, Viral
- Enzyme Inhibitors
- HEK293 Cells
- Humans
- Influenza A Virus, H1N1 Subtype
- Influenza A Virus, H9N2 Subtype
- Influenza A virus
- Kinetics
- Mutation
- Neuraminidase
- Oseltamivir
- Polygala
- Structure-Activity Relationship
- Xanthones
- Journal Article
- Research Support, Non-U.S. Gov't