World Workshop on Oral Medicine VI: A systematic review of medication-induced salivary gland dysfunction

TY - JOUR

T1 - World Workshop on Oral Medicine VI

T2 - A systematic review of medication-induced salivary gland dysfunction

AU - Villa, Alessandro

AU - Wolff, Andy

AU - Narayana, Nagamani

AU - Dawes, Colin

AU - Aframian, Doron J

AU - Lynge Pedersen, Anne Marie

AU - Vissink, Arjan

AU - Aliko, Ardita

AU - Sia, Ying Wai

AU - Joshi, Revan Kumar

AU - McGowan, Richard

AU - Jensen, Siri Beier

AU - Kerr, Alexander Ross

AU - Ekström, Jörgen

AU - Proctor, Gordon

N1 - This article is protected by copyright. All rights reserved.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - The aim of this paper was to perform a systematic review of the pathogenesis of medication-induced salivary gland dysfunction (MISGD). Review of the identified papers was based on the standards regarding the methodology for systematic reviews set forth by the World Workshop on Oral Medicine IV and the PRISMA statement. Eligible papers were assessed for both the degree and strength of relevance to the pathogenesis of MISGD as well as on the appropriateness of the study design and sample size. A total of 99 papers were retained for the final analysis. MISGD in human studies was generally reported as xerostomia (the sensation of oral dryness) without measurements of salivary secretion rate. Medications may act on the central nervous system (CNS) and/or at the neuroglandular junction on muscarinic, α-and β-adrenergic receptors and certain peptidergic receptors. The types of medications that were most commonly implicated for inducing salivary gland dysfunction were those acting on the nervous, cardiovascular, genitourinary, musculoskeletal, respiratory, and alimentary systems. Although many medications may affect the salivary flow rate and composition, most of the studies considered only xerostomia. Thus, further human studies are necessary to improve our understanding of the association between MISGD and the underlying pathophysiology.

AB - The aim of this paper was to perform a systematic review of the pathogenesis of medication-induced salivary gland dysfunction (MISGD). Review of the identified papers was based on the standards regarding the methodology for systematic reviews set forth by the World Workshop on Oral Medicine IV and the PRISMA statement. Eligible papers were assessed for both the degree and strength of relevance to the pathogenesis of MISGD as well as on the appropriateness of the study design and sample size. A total of 99 papers were retained for the final analysis. MISGD in human studies was generally reported as xerostomia (the sensation of oral dryness) without measurements of salivary secretion rate. Medications may act on the central nervous system (CNS) and/or at the neuroglandular junction on muscarinic, α-and β-adrenergic receptors and certain peptidergic receptors. The types of medications that were most commonly implicated for inducing salivary gland dysfunction were those acting on the nervous, cardiovascular, genitourinary, musculoskeletal, respiratory, and alimentary systems. Although many medications may affect the salivary flow rate and composition, most of the studies considered only xerostomia. Thus, further human studies are necessary to improve our understanding of the association between MISGD and the underlying pathophysiology.

U2 - 10.1111/odi.12402

DO - 10.1111/odi.12402

M3 - Review

C2 - 26602059

SN - 1354-523X

VL - 22

SP - 365

EP - 382

JO - Oral Diseases

JF - Oral Diseases

IS - 5

ER -