Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population

Noomi Gregersen; Francesco Lescai; Jieqin Liang; Qibin Li; Thomas Als; Henriette N Buttenschøn; Anne Hedemand; Marjun Biskopstø; Jun Wang; August G Wang; Anders D Børglum; Ole Mors; Ditte Demontis

doi:10.1002/ajmg.b.32464

Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population

Noomi Gregersen, Francesco Lescai, Jieqin Liang, Qibin Li, Thomas Als, Henriette N Buttenschøn, Anne Hedemand, Marjun Biskopstø, Jun Wang, August G Wang, Anders D Børglum, Ole Mors, Ditte Demontis

Department of Clinical Medicine

7 Citations (Scopus)

Abstract

The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic attacks, and genetic factors have been estimated to explain around 40% of the risk. In this study the potential enrichment of PD risk variants was explored based on whole-exome sequencing of 54 patients with PD and 211 control individuals from the Faroese population. No genome-wide significant associations were found, however several single variants and genes showed strong association with PD, where DGKH was found to be the strongest PD associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. Additionally, we found an enrichment of PD risk variants in the Faroese population; variants with otherwise low frequency in more outbreed European populations.

Original language	English
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	171
Issue number	8
Pages (from-to)	1013-1022
Number of pages	10
ISSN	1552-4841
DOIs	https://doi.org/10.1002/ajmg.b.32464
Publication status	Published - 1 Dec 2016

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Gregersen, N., Lescai, F., Liang, J., Li, Q., Als, T., Buttenschøn, H. N., Hedemand, A., Biskopstø, M., Wang, J., Wang, A. G., Børglum, A. D., Mors, O., & Demontis, D. (2016). Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 171(8), 1013-1022. https://doi.org/10.1002/ajmg.b.32464

Gregersen, N, Lescai, F, Liang, J, Li, Q, Als, T, Buttenschøn, HN, Hedemand, A, Biskopstø, M, Wang, J, Wang, AG, Børglum, AD, Mors, O & Demontis, D 2016, 'Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 171, no. 8, pp. 1013-1022. https://doi.org/10.1002/ajmg.b.32464

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title = "Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population",

abstract = "The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic attacks, and genetic factors have been estimated to explain around 40% of the risk. In this study the potential enrichment of PD risk variants was explored based on whole-exome sequencing of 54 patients with PD and 211 control individuals from the Faroese population. No genome-wide significant associations were found, however several single variants and genes showed strong association with PD, where DGKH was found to be the strongest PD associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. Additionally, we found an enrichment of PD risk variants in the Faroese population; variants with otherwise low frequency in more outbreed European populations.",

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AU - Gregersen, Noomi

AU - Lescai, Francesco

AU - Liang, Jieqin

AU - Li, Qibin

AU - Als, Thomas

AU - Buttenschøn, Henriette N

AU - Hedemand, Anne

AU - Biskopstø, Marjun

AU - Wang, Jun

AU - Wang, August G

AU - Børglum, Anders D

AU - Mors, Ole

AU - Demontis, Ditte

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N2 - The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic attacks, and genetic factors have been estimated to explain around 40% of the risk. In this study the potential enrichment of PD risk variants was explored based on whole-exome sequencing of 54 patients with PD and 211 control individuals from the Faroese population. No genome-wide significant associations were found, however several single variants and genes showed strong association with PD, where DGKH was found to be the strongest PD associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. Additionally, we found an enrichment of PD risk variants in the Faroese population; variants with otherwise low frequency in more outbreed European populations.

AB - The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic attacks, and genetic factors have been estimated to explain around 40% of the risk. In this study the potential enrichment of PD risk variants was explored based on whole-exome sequencing of 54 patients with PD and 211 control individuals from the Faroese population. No genome-wide significant associations were found, however several single variants and genes showed strong association with PD, where DGKH was found to be the strongest PD associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. Additionally, we found an enrichment of PD risk variants in the Faroese population; variants with otherwise low frequency in more outbreed European populations.

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JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

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ER -

Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population

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