Whole-body magnetic resonance imaging in inflammatory arthritis: Systematic literature review and first steps toward standardization and an omeract scoring system

Mikkel Østergaard; Iris Eshed; Christian E. Althoff; Rene P. Poggenborg; Torsten Diekhoff; Simon Krabbe; Sabine Weckbach; Robert G.W. Lambert; Susanne J. Pedersen; Walter P. Maksymowych; Charles G. Peterfy; Jane Freeston; Paul Bird; Philip G. Conaghan; Kay Geert A. Hermann

doi:10.3899/jrheum.161114

Whole-body magnetic resonance imaging in inflammatory arthritis: Systematic literature review and first steps toward standardization and an omeract scoring system

Mikkel Østergaard^*, Iris Eshed, Christian E. Althoff, Rene P. Poggenborg, Torsten Diekhoff, Simon Krabbe, Sabine Weckbach, Robert G.W. Lambert, Susanne J. Pedersen, Walter P. Maksymowych, Charles G. Peterfy, Jane Freeston, Paul Bird, Philip G. Conaghan, Kay Geert A. Hermann

^*Corresponding author for this work

Department of Clinical Medicine

24 Citations (Scopus)

Abstract

Objective: Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis. Methods: An SLR was initially performed, searching for WB-MRI studies in arthritis, osteoarthritis, spondyloarthritis, or enthesitis. These results were presented to a meeting of the MRI in Arthritis Working Group together with an MR image review. Following this, preliminary standards for WB-MRI in inflammatory arthritides were developed with further iteration at the Working Group meetings at the Outcome Measures in Rheumatology (OMERACT) 2016. Results: The SLR identified 10 relevant original articles (7 cross-sectional and 3 longitudinal, mostly focusing on synovitis and/or enthesitis in spondyloarthritis, 4 with reproducibility data). The Working Group decided on inflammation in peripheral joints and entheses as primary focus areas, and then developed consensus MRI definitions for these pathologies, selected anatomical locations for assessment, agreed on a core set of MRI sequences and imaging planes for the different regions, and proposed a preliminary scoring system. It was decided to test and further develop the system by iterative multireader exercises. Conclusion: These first steps in developing an OMERACT WB-MRI scoring system for use in inflammatory arthritides offer a framework for further testing and refinement. The Journal of Rheumatology

Original language	English
Journal	Journal of Rheumatology
Volume	44
Issue number	11
Pages (from-to)	1699-1705
Number of pages	7
ISSN	0315-162X
DOIs	https://doi.org/10.3899/jrheum.161114
Publication status	Published - Nov 2017

Keywords

Arthritis
Enthesitis
Magnetic resonance imaging
Omeract
Synovitis

Access to Document

10.3899/jrheum.161114

Cite this

Østergaard, M., Eshed, I., Althoff, C. E., Poggenborg, R. P., Diekhoff, T., Krabbe, S., Weckbach, S., Lambert, R. G. W., Pedersen, S. J., Maksymowych, W. P., Peterfy, C. G., Freeston, J., Bird, P., Conaghan, P. G., & Hermann, K. G. A. (2017). Whole-body magnetic resonance imaging in inflammatory arthritis: Systematic literature review and first steps toward standardization and an omeract scoring system. Journal of Rheumatology, 44(11), 1699-1705. https://doi.org/10.3899/jrheum.161114

Østergaard, M, Eshed, I, Althoff, CE, Poggenborg, RP, Diekhoff, T, Krabbe, S, Weckbach, S, Lambert, RGW, Pedersen, SJ, Maksymowych, WP, Peterfy, CG, Freeston, J, Bird, P, Conaghan, PG & Hermann, KGA 2017, 'Whole-body magnetic resonance imaging in inflammatory arthritis: Systematic literature review and first steps toward standardization and an omeract scoring system', Journal of Rheumatology, vol. 44, no. 11, pp. 1699-1705. https://doi.org/10.3899/jrheum.161114

@article{0107604b648b486b98bb9e2887f3d106,

title = "Whole-body magnetic resonance imaging in inflammatory arthritis: Systematic literature review and first steps toward standardization and an omeract scoring system",

abstract = "Objective: Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis. Methods: An SLR was initially performed, searching for WB-MRI studies in arthritis, osteoarthritis, spondyloarthritis, or enthesitis. These results were presented to a meeting of the MRI in Arthritis Working Group together with an MR image review. Following this, preliminary standards for WB-MRI in inflammatory arthritides were developed with further iteration at the Working Group meetings at the Outcome Measures in Rheumatology (OMERACT) 2016. Results: The SLR identified 10 relevant original articles (7 cross-sectional and 3 longitudinal, mostly focusing on synovitis and/or enthesitis in spondyloarthritis, 4 with reproducibility data). The Working Group decided on inflammation in peripheral joints and entheses as primary focus areas, and then developed consensus MRI definitions for these pathologies, selected anatomical locations for assessment, agreed on a core set of MRI sequences and imaging planes for the different regions, and proposed a preliminary scoring system. It was decided to test and further develop the system by iterative multireader exercises. Conclusion: These first steps in developing an OMERACT WB-MRI scoring system for use in inflammatory arthritides offer a framework for further testing and refinement. The Journal of Rheumatology",

keywords = "Arthritis, Enthesitis, Magnetic resonance imaging, Omeract, Synovitis",

author = "Mikkel {\O}stergaard and Iris Eshed and Althoff, {Christian E.} and Poggenborg, {Rene P.} and Torsten Diekhoff and Simon Krabbe and Sabine Weckbach and Lambert, {Robert G.W.} and Pedersen, {Susanne J.} and Maksymowych, {Walter P.} and Peterfy, {Charles G.} and Jane Freeston and Paul Bird and Conaghan, {Philip G.} and Hermann, {Kay Geert A.}",

year = "2017",

month = nov,

doi = "10.3899/jrheum.161114",

language = "English",

volume = "44",

pages = "1699--1705",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology Publishing Co. Ltd.",

number = "11",

}

TY - JOUR

T1 - Whole-body magnetic resonance imaging in inflammatory arthritis

T2 - Systematic literature review and first steps toward standardization and an omeract scoring system

AU - Østergaard, Mikkel

AU - Eshed, Iris

AU - Althoff, Christian E.

AU - Poggenborg, Rene P.

AU - Diekhoff, Torsten

AU - Krabbe, Simon

AU - Weckbach, Sabine

AU - Lambert, Robert G.W.

AU - Pedersen, Susanne J.

AU - Maksymowych, Walter P.

AU - Peterfy, Charles G.

AU - Freeston, Jane

AU - Bird, Paul

AU - Conaghan, Philip G.

AU - Hermann, Kay Geert A.

PY - 2017/11

Y1 - 2017/11

N2 - Objective: Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis. Methods: An SLR was initially performed, searching for WB-MRI studies in arthritis, osteoarthritis, spondyloarthritis, or enthesitis. These results were presented to a meeting of the MRI in Arthritis Working Group together with an MR image review. Following this, preliminary standards for WB-MRI in inflammatory arthritides were developed with further iteration at the Working Group meetings at the Outcome Measures in Rheumatology (OMERACT) 2016. Results: The SLR identified 10 relevant original articles (7 cross-sectional and 3 longitudinal, mostly focusing on synovitis and/or enthesitis in spondyloarthritis, 4 with reproducibility data). The Working Group decided on inflammation in peripheral joints and entheses as primary focus areas, and then developed consensus MRI definitions for these pathologies, selected anatomical locations for assessment, agreed on a core set of MRI sequences and imaging planes for the different regions, and proposed a preliminary scoring system. It was decided to test and further develop the system by iterative multireader exercises. Conclusion: These first steps in developing an OMERACT WB-MRI scoring system for use in inflammatory arthritides offer a framework for further testing and refinement. The Journal of Rheumatology

AB - Objective: Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis. Methods: An SLR was initially performed, searching for WB-MRI studies in arthritis, osteoarthritis, spondyloarthritis, or enthesitis. These results were presented to a meeting of the MRI in Arthritis Working Group together with an MR image review. Following this, preliminary standards for WB-MRI in inflammatory arthritides were developed with further iteration at the Working Group meetings at the Outcome Measures in Rheumatology (OMERACT) 2016. Results: The SLR identified 10 relevant original articles (7 cross-sectional and 3 longitudinal, mostly focusing on synovitis and/or enthesitis in spondyloarthritis, 4 with reproducibility data). The Working Group decided on inflammation in peripheral joints and entheses as primary focus areas, and then developed consensus MRI definitions for these pathologies, selected anatomical locations for assessment, agreed on a core set of MRI sequences and imaging planes for the different regions, and proposed a preliminary scoring system. It was decided to test and further develop the system by iterative multireader exercises. Conclusion: These first steps in developing an OMERACT WB-MRI scoring system for use in inflammatory arthritides offer a framework for further testing and refinement. The Journal of Rheumatology

KW - Arthritis

KW - Enthesitis

KW - Magnetic resonance imaging

KW - Omeract

KW - Synovitis

U2 - 10.3899/jrheum.161114

DO - 10.3899/jrheum.161114

M3 - Review

C2 - 28620061

AN - SCOPUS:85032647072

SN - 0315-162X

VL - 44

SP - 1699

EP - 1705

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 11

ER -

Whole-body magnetic resonance imaging in inflammatory arthritis: Systematic literature review and first steps toward standardization and an omeract scoring system

Abstract

Keywords

Access to Document

Fingerprint

Cite this