WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience

Ann B Madelung; Henrik Bondo; Inger Stamp; Preben Løvgreen; Signe L Nielsen; Anne Falensteen; Helle Knudsen; Kira D Svendsen; Theis Lange; Elisabeth Ralfkiaer; Karsten Nielsen; Hans Hasselbalch; Jürgen Thiele

doi:10.1111/apm.12417

WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience

Ann B Madelung, Henrik Bondo, Inger Stamp, Preben Løvgreen, Signe L Nielsen, Anne Falensteen, Helle Knudsen, Kira D Svendsen, Theis Lange, Elisabeth Ralfkiaer, Karsten Nielsen, Hans Hasselbalch, Jürgen Thiele

3 Citations (Scopus)

Abstract

We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p = 0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis.

Original language	English
Journal	APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Volume	123
Issue number	9
Pages (from-to)	787-92
Number of pages	6
ISSN	0903-4641
DOIs	https://doi.org/10.1111/apm.12417
Publication status	Published - 1 Sept 2015

Keywords

Adult
Biopsy
Bone Marrow
Bone Marrow Neoplasms
Case-Control Studies
Humans
Myeloproliferative Disorders
World Health Organization
Young Adult

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10.1111/apm.12417

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Madelung, A. B., Bondo, H., Stamp, I., Løvgreen, P., Nielsen, S. L., Falensteen, A., Knudsen, H., Svendsen, K. D., Lange, T., Ralfkiaer, E., Nielsen, K., Hasselbalch, H., & Thiele, J. (2015). WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 123(9), 787-92. https://doi.org/10.1111/apm.12417

Madelung, AB, Bondo, H, Stamp, I, Løvgreen, P, Nielsen, SL, Falensteen, A, Knudsen, H, Svendsen, KD, Lange, T, Ralfkiaer, E, Nielsen, K, Hasselbalch, H & Thiele, J 2015, 'WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience', APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, vol. 123, no. 9, pp. 787-92. https://doi.org/10.1111/apm.12417

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abstract = "We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p = 0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis.",

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AU - Nielsen, Signe L

AU - Falensteen, Anne

AU - Knudsen, Helle

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WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience

Abstract

Keywords

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