WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience

TY - JOUR

T1 - WHO classification 2008 of myeloproliferative neoplasms

T2 - a workshop learning effect - the Danish experience

AU - Madelung, Ann B

AU - Bondo, Henrik

AU - Stamp, Inger

AU - Løvgreen, Preben

AU - Nielsen, Signe L

AU - Falensteen, Anne

AU - Knudsen, Helle

AU - Svendsen, Kira D

AU - Lange, Theis

AU - Ralfkiaer, Elisabeth

AU - Nielsen, Karsten

AU - Hasselbalch, Hans

AU - Thiele, Jürgen

N1 - © 2015 APMIS. Published by John Wiley & Sons Ltd.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p = 0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis.

AB - We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p = 0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis.

KW - Adult

KW - Biopsy

KW - Bone Marrow

KW - Bone Marrow Neoplasms

KW - Case-Control Studies

KW - Humans

KW - Myeloproliferative Disorders

KW - World Health Organization

KW - Young Adult

U2 - 10.1111/apm.12417

DO - 10.1111/apm.12417

M3 - Journal article

C2 - 26200697

SN - 0903-4641

VL - 123

SP - 787

EP - 792

JO - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

IS - 9

ER -