What factors influence the health status of patients with rheumatoid arthritis measured by the SF-12v2 Health Survey and the Health Assessment Questionnaire?

Louise Linde; Jan Sørensen; Mikkel Østergaard; Kim Hørslev-Petersen; Claus Rasmussen; Dorte Vendelbo Jensen; Merete Lund Hetland; Louise Linde; Jan Sørensen; Mikkel Østergaard; Kim Hørslev-Petersen; Claus Rasmussen; Dorte Vendelbo Jensen; Merete Lund Hetland

doi:10.3899/jrheum.090134

What factors influence the health status of patients with rheumatoid arthritis measured by the SF-12v2 Health Survey and the Health Assessment Questionnaire?

Louise Linde, Jan Sørensen, Mikkel Østergaard, Kim Hørslev-Petersen, Claus Rasmussen, Dorte Vendelbo Jensen, Merete Lund Hetland, Louise Linde, Jan Sørensen, Mikkel Østergaard, Kim Hørslev-Petersen, Claus Rasmussen, Dorte Vendelbo Jensen, Merete Lund Hetland

36 Citations (Scopus)

Abstract

OBJECTIVE: The Health Assessment Questionnaire Disability Index (HAQ) is a widely used outcome measure in rheumatoid arthritis (RA), whereas the SF-12v2 Health Survey (SF-12) was introduced recently. We investigated how the HAQ and SF-12 were associated with socio-demographic, lifestyle, and disease- and treatment-related factors in patients with RA. METHODS: In RA patients from 11 Danish centers, clinical and patient-reported data, including the HAQ and SF-12, were collected. Three multiple linear regression models were estimated, with the HAQ, SF-12 physical component score (PCS), and SF-12 mental component score (MCS) as outcome and sociodemographic, lifestyle, and RA-related treatment and comorbidity characteristics as explanatory variables. RESULTS: In total, 3156 (85%) of 3704 invited patients participated--75% women, 76% rheumatoid factor-positive, median age 61 years (range 15-93 yrs), disease duration 7 years (range 0-68 yrs), Disease Activity Score on 28 joints (DAS28) 2.97 (range 0.96-8.61), HAQ score 0.63 (range 0-3), SF-12 PCS 56 (range 6-99), and SF-12 MCS 57 (range 16-99). Variation in HAQ was associated with 12 of 15 possible variables (R(2) 0.41), in PCS and MCS with 6 of 15 variables (R(2) 0.02 and 0.05). Patients with moderate to high DAS28 and > or = 3 comorbid conditions had consistently worse HAQ and SF-12 scores compared to the reference groups, while weekly exercise was associated with better scores compared to no exercise. CONCLUSION: The HAQ was more sensitive to differences in demographic, lifestyle, and disease- and treatment-related factors than the SF-12. The established clinical value and feasibility of the HAQ highlights its advantages over the SF-12 in describing health status in RA.

Original language	English
Journal	Journal of Rheumatology
Volume	36
Issue number	10
Pages (from-to)	2183-9
Number of pages	6
ISSN	0315-162X
DOIs	https://doi.org/10.3899/jrheum.090134 https://doi.org/10.3899/jrheum.090134
Publication status	Published - 2009

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Linde, L., Sørensen, J., Østergaard, M., Hørslev-Petersen, K., Rasmussen, C., Jensen, D. V., Hetland, M. L., Linde, L., Sørensen, J., Østergaard, M., Hørslev-Petersen, K., Rasmussen, C., Jensen, D. V., & Hetland, M. L. (2009). What factors influence the health status of patients with rheumatoid arthritis measured by the SF-12v2 Health Survey and the Health Assessment Questionnaire? Journal of Rheumatology, 36(10), 2183-9. https://doi.org/10.3899/jrheum.090134, https://doi.org/10.3899/jrheum.090134

Linde, L, Sørensen, J , Østergaard, M, Hørslev-Petersen, K, Rasmussen, C, Jensen, DV, Hetland, ML, Linde, L, Sørensen, J, Østergaard, M, Hørslev-Petersen, K, Rasmussen, C, Jensen, DV & Hetland, ML 2009, 'What factors influence the health status of patients with rheumatoid arthritis measured by the SF-12v2 Health Survey and the Health Assessment Questionnaire?', Journal of Rheumatology, vol. 36, no. 10, pp. 2183-9. https://doi.org/10.3899/jrheum.090134, https://doi.org/10.3899/jrheum.090134

@article{d9bd72c0b42711df825b000ea68e967b,

title = "What factors influence the health status of patients with rheumatoid arthritis measured by the SF-12v2 Health Survey and the Health Assessment Questionnaire?",

abstract = "OBJECTIVE: The Health Assessment Questionnaire Disability Index (HAQ) is a widely used outcome measure in rheumatoid arthritis (RA), whereas the SF-12v2 Health Survey (SF-12) was introduced recently. We investigated how the HAQ and SF-12 were associated with socio-demographic, lifestyle, and disease- and treatment-related factors in patients with RA. METHODS: In RA patients from 11 Danish centers, clinical and patient-reported data, including the HAQ and SF-12, were collected. Three multiple linear regression models were estimated, with the HAQ, SF-12 physical component score (PCS), and SF-12 mental component score (MCS) as outcome and sociodemographic, lifestyle, and RA-related treatment and comorbidity characteristics as explanatory variables. RESULTS: In total, 3156 (85%) of 3704 invited patients participated--75% women, 76% rheumatoid factor-positive, median age 61 years (range 15-93 yrs), disease duration 7 years (range 0-68 yrs), Disease Activity Score on 28 joints (DAS28) 2.97 (range 0.96-8.61), HAQ score 0.63 (range 0-3), SF-12 PCS 56 (range 6-99), and SF-12 MCS 57 (range 16-99). Variation in HAQ was associated with 12 of 15 possible variables (R(2) 0.41), in PCS and MCS with 6 of 15 variables (R(2) 0.02 and 0.05). Patients with moderate to high DAS28 and > or = 3 comorbid conditions had consistently worse HAQ and SF-12 scores compared to the reference groups, while weekly exercise was associated with better scores compared to no exercise. CONCLUSION: The HAQ was more sensitive to differences in demographic, lifestyle, and disease- and treatment-related factors than the SF-12. The established clinical value and feasibility of the HAQ highlights its advantages over the SF-12 in describing health status in RA.",

author = "Louise Linde and Jan S{\o}rensen and Mikkel {\O}stergaard and Kim H{\o}rslev-Petersen and Claus Rasmussen and Jensen, {Dorte Vendelbo} and Hetland, {Merete Lund} and Louise Linde and Jan S{\o}rensen and Mikkel {\O}stergaard and Kim H{\o}rslev-Petersen and Claus Rasmussen and Jensen, {Dorte Vendelbo} and Hetland, {Merete Lund}",

note = "Keywords: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cross-Sectional Studies; Denmark; Disability Evaluation; Female; Health Status Indicators; Health Surveys; Humans; Life Style; Male; Middle Aged; Regression Analysis; Severity of Illness Index; Social Class",

year = "2009",

doi = "10.3899/jrheum.090134",

language = "English",

volume = "36",

pages = "2183--9",

journal = "Journal of Rheumatology",

issn = "0315-162X",