Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring - The WARM Study

Susanne Harder; Kirstine Agnete Davidsen; Angus  MacBeth; Theis Lange; Helen Minnis; Marianne Skovsager Andersen; Erik Simonsen; Jenna Marie  Lundy; Maja Nyström-Hansen; Christopher Trier Lind; Katrine Røhder; Andrew Gumley

doi:10.1186/s12888-015-0692-6

Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring - The WARM Study

Susanne Harder, Kirstine Agnete Davidsen, Angus MacBeth, Theis Lange, Helen Minnis, Marianne Skovsager Andersen, Erik Simonsen, Jenna Marie Lundy, Maja Nyström-Hansen, Christopher Trier Lind, Katrine Røhder, Andrew Gumley

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Abstract

The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age. Background: Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction. Methods/Design: We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction. Discussion: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.

Original language	English
Article number	310
Journal	B M C Psychiatry
Volume	15
Pages (from-to)	1-13
Number of pages	13
ISSN	1471-244X
DOIs	https://doi.org/10.1186/s12888-015-0692-6
Publication status	Published - 9 Dec 2015

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Harder et al (2015) WARM protocol Final published version, 749 KB

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Harder, S., Davidsen, K. A., MacBeth, A., Lange, T., Minnis, H., Skovsager Andersen, M., Simonsen, E., Lundy, J. M., Nyström-Hansen, M., Lind, C. T., Røhder, K., & Gumley, A. (2015). Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring - The WARM Study. B M C Psychiatry, 15, 1-13. [310]. https://doi.org/10.1186/s12888-015-0692-6

Wellbeing And Resilience : Mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring - The WARM Study. / Harder, Susanne; Davidsen, Kirstine Agnete; MacBeth, Angus et al.

In: B M C Psychiatry, Vol. 15, 310, 09.12.2015, p. 1-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harder, S, Davidsen, KA, MacBeth, A, Lange, T, Minnis, H, Skovsager Andersen, M, Simonsen, E, Lundy, JM, Nyström-Hansen, M , Lind, CT , Røhder, K & Gumley, A 2015, 'Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring - The WARM Study', B M C Psychiatry, vol. 15, 310, pp. 1-13. https://doi.org/10.1186/s12888-015-0692-6

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title = "Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring - The WARM Study",

abstract = "The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age. Background: Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction. Methods/Design: We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction. Discussion: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.",

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doi = "10.1186/s12888-015-0692-6",

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T2 - Mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring - The WARM Study

AU - Harder, Susanne

AU - Davidsen, Kirstine Agnete

AU - MacBeth, Angus

AU - Lange, Theis

AU - Minnis, Helen

AU - Skovsager Andersen, Marianne

AU - Simonsen, Erik

AU - Lundy, Jenna Marie

AU - Nyström-Hansen, Maja

AU - Lind, Christopher Trier

AU - Røhder, Katrine

AU - Gumley, Andrew

PY - 2015/12/9

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N2 - The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age. Background: Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction. Methods/Design: We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction. Discussion: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.

AB - The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age. Background: Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction. Methods/Design: We are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction. Discussion: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.

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ER -

Wellbeing And Resilience: Mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring - The WARM Study

Abstract

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