Weight-specific anticipatory coding of grip force in human dorsal premotor cortex

Bart F L van Nuenen; Johann Kuhtz-Buschbeck; Christian Schulz; Bastiaan R Bloem; Hartwig R Siebner

doi:10.1523/JNEUROSCI.5673-11.2012

Weight-specific anticipatory coding of grip force in human dorsal premotor cortex

Bart F L van Nuenen, Johann Kuhtz-Buschbeck, Christian Schulz, Bastiaan R Bloem, Hartwig R Siebner

21 Citations (Scopus)

Abstract

The dorsal premotor cortex (PMd) uses prior sensory information for motor preparation. Here, we used a conditioning-and-map approach in 11 healthy male humans (mean age 27 years) to further clarify the role of PMd in anticipatory motor control. We transiently disrupted neuronal processing in PMd, using either continuous theta burst stimulation (cTBS) at 80% (inhibitory cTBS) or 30% (sham cTBS) of active motor threshold. The conditioning effects of cTBS on preparatory brain activity were assessed with functional MRI, while participants lifted a light or heavy weight in response to a go-cue (S2). An additional pre-cue (S1) correctly predicted the weight in 75% of the trials. Participants were asked to use this prior information to prepare for the lift. In the sham condition, grip force showed a consistent undershoot, if the S1 incorrectly prompted the preparation of a light lift. Likewise, an S1 that falsely announced a heavy weight produced a consistent overshoot in grip force. In trials with incorrect S1, preparatory activity in left PMd during the S1-S2 delay period predicted grip force undershoot but not overshoot. Real cTBS selectively abolished this undershoot in grip force. Furthermore, preparatory S1-S2 activity in left PMd no longer predicted the individual undershoot after real cTBS. Our results provide converging evidence for a causal involvement of PMd in anticipatory downscaling but not upscaling of grip force, suggesting an inhibitory role of PMd in anticipatory grip force control during object lifting.

Original language	English
Journal	Journal of Neuroscience
Volume	32
Issue number	15
Pages (from-to)	5272-83
Number of pages	12
ISSN	0270-6474
DOIs	https://doi.org/10.1523/JNEUROSCI.5673-11.2012
Publication status	Published - 11 Apr 2012

Keywords

Adult
Analysis of Variance
Cues
Evoked Potentials, Motor
Hand
Hand Strength
Humans
Lifting
Magnetic Resonance Imaging
Male
Motor Cortex
Oxygen
Photic Stimulation
Pyramidal Tracts
Reaction Time
Reproducibility of Results
Theta Rhythm
Weight Perception
Young Adult

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10.1523/JNEUROSCI.5673-11.2012

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title = "Weight-specific anticipatory coding of grip force in human dorsal premotor cortex",

abstract = "The dorsal premotor cortex (PMd) uses prior sensory information for motor preparation. Here, we used a conditioning-and-map approach in 11 healthy male humans (mean age 27 years) to further clarify the role of PMd in anticipatory motor control. We transiently disrupted neuronal processing in PMd, using either continuous theta burst stimulation (cTBS) at 80% (inhibitory cTBS) or 30% (sham cTBS) of active motor threshold. The conditioning effects of cTBS on preparatory brain activity were assessed with functional MRI, while participants lifted a light or heavy weight in response to a go-cue (S2). An additional pre-cue (S1) correctly predicted the weight in 75% of the trials. Participants were asked to use this prior information to prepare for the lift. In the sham condition, grip force showed a consistent undershoot, if the S1 incorrectly prompted the preparation of a light lift. Likewise, an S1 that falsely announced a heavy weight produced a consistent overshoot in grip force. In trials with incorrect S1, preparatory activity in left PMd during the S1-S2 delay period predicted grip force undershoot but not overshoot. Real cTBS selectively abolished this undershoot in grip force. Furthermore, preparatory S1-S2 activity in left PMd no longer predicted the individual undershoot after real cTBS. Our results provide converging evidence for a causal involvement of PMd in anticipatory downscaling but not upscaling of grip force, suggesting an inhibitory role of PMd in anticipatory grip force control during object lifting.",

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author = "{van Nuenen}, {Bart F L} and Johann Kuhtz-Buschbeck and Christian Schulz and Bloem, {Bastiaan R} and Siebner, {Hartwig R}",

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doi = "10.1523/JNEUROSCI.5673-11.2012",

language = "English",

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T1 - Weight-specific anticipatory coding of grip force in human dorsal premotor cortex

AU - van Nuenen, Bart F L

AU - Kuhtz-Buschbeck, Johann

AU - Schulz, Christian

AU - Bloem, Bastiaan R

AU - Siebner, Hartwig R

PY - 2012/4/11

Y1 - 2012/4/11

N2 - The dorsal premotor cortex (PMd) uses prior sensory information for motor preparation. Here, we used a conditioning-and-map approach in 11 healthy male humans (mean age 27 years) to further clarify the role of PMd in anticipatory motor control. We transiently disrupted neuronal processing in PMd, using either continuous theta burst stimulation (cTBS) at 80% (inhibitory cTBS) or 30% (sham cTBS) of active motor threshold. The conditioning effects of cTBS on preparatory brain activity were assessed with functional MRI, while participants lifted a light or heavy weight in response to a go-cue (S2). An additional pre-cue (S1) correctly predicted the weight in 75% of the trials. Participants were asked to use this prior information to prepare for the lift. In the sham condition, grip force showed a consistent undershoot, if the S1 incorrectly prompted the preparation of a light lift. Likewise, an S1 that falsely announced a heavy weight produced a consistent overshoot in grip force. In trials with incorrect S1, preparatory activity in left PMd during the S1-S2 delay period predicted grip force undershoot but not overshoot. Real cTBS selectively abolished this undershoot in grip force. Furthermore, preparatory S1-S2 activity in left PMd no longer predicted the individual undershoot after real cTBS. Our results provide converging evidence for a causal involvement of PMd in anticipatory downscaling but not upscaling of grip force, suggesting an inhibitory role of PMd in anticipatory grip force control during object lifting.

AB - The dorsal premotor cortex (PMd) uses prior sensory information for motor preparation. Here, we used a conditioning-and-map approach in 11 healthy male humans (mean age 27 years) to further clarify the role of PMd in anticipatory motor control. We transiently disrupted neuronal processing in PMd, using either continuous theta burst stimulation (cTBS) at 80% (inhibitory cTBS) or 30% (sham cTBS) of active motor threshold. The conditioning effects of cTBS on preparatory brain activity were assessed with functional MRI, while participants lifted a light or heavy weight in response to a go-cue (S2). An additional pre-cue (S1) correctly predicted the weight in 75% of the trials. Participants were asked to use this prior information to prepare for the lift. In the sham condition, grip force showed a consistent undershoot, if the S1 incorrectly prompted the preparation of a light lift. Likewise, an S1 that falsely announced a heavy weight produced a consistent overshoot in grip force. In trials with incorrect S1, preparatory activity in left PMd during the S1-S2 delay period predicted grip force undershoot but not overshoot. Real cTBS selectively abolished this undershoot in grip force. Furthermore, preparatory S1-S2 activity in left PMd no longer predicted the individual undershoot after real cTBS. Our results provide converging evidence for a causal involvement of PMd in anticipatory downscaling but not upscaling of grip force, suggesting an inhibitory role of PMd in anticipatory grip force control during object lifting.

KW - Adult

KW - Analysis of Variance

KW - Cues

KW - Evoked Potentials, Motor

KW - Hand

KW - Hand Strength

KW - Humans

KW - Lifting

KW - Magnetic Resonance Imaging

KW - Male

KW - Motor Cortex

KW - Oxygen

KW - Photic Stimulation

KW - Pyramidal Tracts

KW - Reaction Time

KW - Reproducibility of Results

KW - Theta Rhythm

KW - Weight Perception

KW - Young Adult

U2 - 10.1523/JNEUROSCI.5673-11.2012

DO - 10.1523/JNEUROSCI.5673-11.2012

M3 - Journal article

C2 - 22496573

SN - 0270-6474

VL - 32

SP - 5272

EP - 5283

JO - The Journal of neuroscience : the official journal of the Society for Neuroscience

JF - The Journal of neuroscience : the official journal of the Society for Neuroscience

IS - 15

ER -

Weight-specific anticipatory coding of grip force in human dorsal premotor cortex

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Keywords

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