Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania

George Praygod; Nyagosya Range; Daniel Faurholt-Jepsen; Jeremiah Kidola; Maria Faurholt-Jepsen; Martine G. Aabye; Lotte Jensen; Andreas V. Jensen; Harleen M.S. Grewal; Pascal Magnussen; John Changalucha; Åse Bengård Andersen; Henrik Friis

doi:10.1016/j.trstmh.2010.11.009

Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania

George Praygod, Nyagosya Range, Daniel Faurholt-Jepsen, Jeremiah Kidola, Maria Faurholt-Jepsen, Martine G. Aabye, Lotte Jensen, Andreas V. Jensen, Harleen M.S. Grewal, Pascal Magnussen, John Changalucha, Åse Bengård Andersen, Henrik Friis

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30 Citations (Scopus)

Abstract

This study aimed to estimate deficits in weight, arm fat area (AFA), arm muscle area (AMA) and handgrip strength among smear-positive pulmonary TB (PTB+) patients starting treatment. We conducted a cross-sectional study among PTB+ patients and age- and sex-matched neighborhood controls. HIV status, anthropometric measurements and handgrip strength were determined. Deficits in weight, AFA, AMA and handgrip strength associated with PTB+ and HIV were estimated using multiple regression analysis. We recruited 355 pairs of PTB+ patients and controls. PTB+ was associated with deficits of 10.0. kg (95% CI 7.3; 12.7) in weight and 6.8. kg (95% CI 5.2; 8.3) in handgrip strength among females and 9.1. kg (95% CI 7.3; 10.9) in weight and 6.8. kg (95% CI 5.2; 8.4) in handgrip strength among males. In both sexes, PTB+ was associated with deficits in AFA and AMA. Among females, HIV was associated with deficits in AMA and handgrip strength, but the deficit in handgrip strength was larger among PTB+ patients (3.2. kg 95% CI 1.3; 5.2) than controls (-1.6. kg 95% CI -4.8; 1.5) (interaction, P = 0.009).These findings suggest that deficits in weight and handgrip strength among patients starting TB treatment are severe. Thus, nutritional support may be necessary to ensure reversal of the deficits, and may improve treatment outcomes.

Original language	English
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	105
Issue number	3
Pages (from-to)	140-147
Number of pages	8
ISSN	0035-9203
DOIs	https://doi.org/10.1016/j.trstmh.2010.11.009
Publication status	Published - Mar 2011

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Praygod, G., Range, N., Faurholt-Jepsen, D., Kidola, J., Faurholt-Jepsen, M., Aabye, M. G., Jensen, L., Jensen, A. V., Grewal, H. M. S., Magnussen, P., Changalucha, J., Andersen, Å. B., & Friis, H. (2011). Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene, 105(3), 140-147. https://doi.org/10.1016/j.trstmh.2010.11.009

Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania. / Praygod, George; Range, Nyagosya; Faurholt-Jepsen, Daniel et al.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 105, No. 3, 03.2011, p. 140-147.

Research output: Contribution to journal › Journal article › Research › peer-review

Praygod, G, Range, N, Faurholt-Jepsen, D, Kidola, J, Faurholt-Jepsen, M, Aabye, MG, Jensen, L, Jensen, AV, Grewal, HMS, Magnussen, P, Changalucha, J, Andersen, ÅB & Friis, H 2011, 'Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 105, no. 3, pp. 140-147. https://doi.org/10.1016/j.trstmh.2010.11.009

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title = "Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania",

abstract = "This study aimed to estimate deficits in weight, arm fat area (AFA), arm muscle area (AMA) and handgrip strength among smear-positive pulmonary TB (PTB+) patients starting treatment. We conducted a cross-sectional study among PTB+ patients and age- and sex-matched neighborhood controls. HIV status, anthropometric measurements and handgrip strength were determined. Deficits in weight, AFA, AMA and handgrip strength associated with PTB+ and HIV were estimated using multiple regression analysis. We recruited 355 pairs of PTB+ patients and controls. PTB+ was associated with deficits of 10.0. kg (95% CI 7.3; 12.7) in weight and 6.8. kg (95% CI 5.2; 8.3) in handgrip strength among females and 9.1. kg (95% CI 7.3; 10.9) in weight and 6.8. kg (95% CI 5.2; 8.4) in handgrip strength among males. In both sexes, PTB+ was associated with deficits in AFA and AMA. Among females, HIV was associated with deficits in AMA and handgrip strength, but the deficit in handgrip strength was larger among PTB+ patients (3.2. kg 95% CI 1.3; 5.2) than controls (-1.6. kg 95% CI -4.8; 1.5) (interaction, P = 0.009).These findings suggest that deficits in weight and handgrip strength among patients starting TB treatment are severe. Thus, nutritional support may be necessary to ensure reversal of the deficits, and may improve treatment outcomes.",

author = "George Praygod and Nyagosya Range and Daniel Faurholt-Jepsen and Jeremiah Kidola and Maria Faurholt-Jepsen and Aabye, {Martine G.} and Lotte Jensen and Jensen, {Andreas V.} and Grewal, {Harleen M.S.} and Pascal Magnussen and John Changalucha and Andersen, {{\AA}se Beng{\aa}rd} and Henrik Friis",

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doi = "10.1016/j.trstmh.2010.11.009",

language = "English",

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pages = "140--147",

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T1 - Weight, body composition and handgrip strength among pulmonary tuberculosis patients

T2 - a matched cross-sectional study in Mwanza, Tanzania

AU - Praygod, George

AU - Range, Nyagosya

AU - Faurholt-Jepsen, Daniel

AU - Kidola, Jeremiah

AU - Faurholt-Jepsen, Maria

AU - Aabye, Martine G.

AU - Jensen, Lotte

AU - Jensen, Andreas V.

AU - Grewal, Harleen M.S.

AU - Magnussen, Pascal

AU - Changalucha, John

AU - Andersen, Åse Bengård

AU - Friis, Henrik

PY - 2011/3

Y1 - 2011/3

N2 - This study aimed to estimate deficits in weight, arm fat area (AFA), arm muscle area (AMA) and handgrip strength among smear-positive pulmonary TB (PTB+) patients starting treatment. We conducted a cross-sectional study among PTB+ patients and age- and sex-matched neighborhood controls. HIV status, anthropometric measurements and handgrip strength were determined. Deficits in weight, AFA, AMA and handgrip strength associated with PTB+ and HIV were estimated using multiple regression analysis. We recruited 355 pairs of PTB+ patients and controls. PTB+ was associated with deficits of 10.0. kg (95% CI 7.3; 12.7) in weight and 6.8. kg (95% CI 5.2; 8.3) in handgrip strength among females and 9.1. kg (95% CI 7.3; 10.9) in weight and 6.8. kg (95% CI 5.2; 8.4) in handgrip strength among males. In both sexes, PTB+ was associated with deficits in AFA and AMA. Among females, HIV was associated with deficits in AMA and handgrip strength, but the deficit in handgrip strength was larger among PTB+ patients (3.2. kg 95% CI 1.3; 5.2) than controls (-1.6. kg 95% CI -4.8; 1.5) (interaction, P = 0.009).These findings suggest that deficits in weight and handgrip strength among patients starting TB treatment are severe. Thus, nutritional support may be necessary to ensure reversal of the deficits, and may improve treatment outcomes.

AB - This study aimed to estimate deficits in weight, arm fat area (AFA), arm muscle area (AMA) and handgrip strength among smear-positive pulmonary TB (PTB+) patients starting treatment. We conducted a cross-sectional study among PTB+ patients and age- and sex-matched neighborhood controls. HIV status, anthropometric measurements and handgrip strength were determined. Deficits in weight, AFA, AMA and handgrip strength associated with PTB+ and HIV were estimated using multiple regression analysis. We recruited 355 pairs of PTB+ patients and controls. PTB+ was associated with deficits of 10.0. kg (95% CI 7.3; 12.7) in weight and 6.8. kg (95% CI 5.2; 8.3) in handgrip strength among females and 9.1. kg (95% CI 7.3; 10.9) in weight and 6.8. kg (95% CI 5.2; 8.4) in handgrip strength among males. In both sexes, PTB+ was associated with deficits in AFA and AMA. Among females, HIV was associated with deficits in AMA and handgrip strength, but the deficit in handgrip strength was larger among PTB+ patients (3.2. kg 95% CI 1.3; 5.2) than controls (-1.6. kg 95% CI -4.8; 1.5) (interaction, P = 0.009).These findings suggest that deficits in weight and handgrip strength among patients starting TB treatment are severe. Thus, nutritional support may be necessary to ensure reversal of the deficits, and may improve treatment outcomes.

U2 - 10.1016/j.trstmh.2010.11.009

DO - 10.1016/j.trstmh.2010.11.009

M3 - Journal article

C2 - 21239027

SN - 0035-9203

VL - 105

SP - 140

EP - 147

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 3

ER -

Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania

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