Weight and weight gain during early infancy predict childhood obesity: a case-cohort study

Lise Geisler Andersen; Claus Holst; Kim F. Michaelsen; J L Baker; Thorkild I.A. Sørensen

doi:10.1038/ijo.2012.134

Weight and weight gain during early infancy predict childhood obesity: a case-cohort study

Lise Geisler Andersen, Claus Holst, Kim F. Michaelsen, J L Baker, Thorkild I.A. Sørensen

40 Citations (Scopus)

Abstract

Background:Infant weight and weight gain are positively associated with later obesity, but whether there is a particular critical time during infancy remains uncertain.Objective:The aim was to investigate when and how weight and weight gain during infancy become associated with childhood obesity.Methods:In a cohort representing 28 340 children born from 1959–67 and measured in Copenhagen schools, 962 obese children (2007 World Health Organization criteria), were compared with a 5% randomly selected sub-cohort of 1417 children. Information on weight at birth, 2 weeks, 1, 2, 3, 4, 6 and 9 months was retrieved from health visitors’ records. Odds ratios and 95% confidence intervals (CI) for childhood obesity by tertiles of weight at each age and by change in tertiles of weight between two consecutive measurements were estimated using multivariate logistic regression with adjustment for indicators of socioeconomic status, preterm birth, and breastfeeding.Results:Compared with children in the middle weight-tertile, children with a weight in the upper tertile had a 1.36-fold (CI, 1.10–1.69) to 1.72-fold (CI, 1.36–2.18) higher risk of childhood obesity from birth through 9 months, whereas children in the lower weight-tertile had almost half the risk of obesity from 2 through 9 months. The risk of childhood obesity associated with change in weight-tertile in each interval was stable at ∼1.5-fold per weight-tertile increase throughout infancy.Conclusions:Infant weight and weight gain are associated with obesity in childhood already during the first months of life. Determinants of weight gain shortly after birth may be a suitable target for prevention of obesity.

Original language	English
Journal	International Journal of Obesity
Volume	36
Issue number	10
Pages (from-to)	1306-1311
Number of pages	6
ISSN	0307-0565
DOIs	https://doi.org/10.1038/ijo.2012.134
Publication status	Published - Oct 2012

Keywords

Adult
Age of Onset
Body Weight
Breast Feeding
Case-Control Studies
Cohort Studies
Denmark
Epigenomics
European Continental Ancestry Group
Female
Humans
Infant
Infant Formula
Infant Nutritional Physiological Phenomena
Infant, Newborn
Male
Obesity
Odds Ratio
Predictive Value of Tests
Pregnancy
Weight Gain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ijo.2012.134

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title = "Weight and weight gain during early infancy predict childhood obesity: a case-cohort study",

abstract = "Background:Infant weight and weight gain are positively associated with later obesity, but whether there is a particular critical time during infancy remains uncertain.Objective:The aim was to investigate when and how weight and weight gain during infancy become associated with childhood obesity.Methods:In a cohort representing 28 340 children born from 1959–67 and measured in Copenhagen schools, 962 obese children (2007 World Health Organization criteria), were compared with a 5% randomly selected sub-cohort of 1417 children. Information on weight at birth, 2 weeks, 1, 2, 3, 4, 6 and 9 months was retrieved from health visitors{\textquoteright} records. Odds ratios and 95% confidence intervals (CI) for childhood obesity by tertiles of weight at each age and by change in tertiles of weight between two consecutive measurements were estimated using multivariate logistic regression with adjustment for indicators of socioeconomic status, preterm birth, and breastfeeding.Results:Compared with children in the middle weight-tertile, children with a weight in the upper tertile had a 1.36-fold (CI, 1.10–1.69) to 1.72-fold (CI, 1.36–2.18) higher risk of childhood obesity from birth through 9 months, whereas children in the lower weight-tertile had almost half the risk of obesity from 2 through 9 months. The risk of childhood obesity associated with change in weight-tertile in each interval was stable at ∼1.5-fold per weight-tertile increase throughout infancy.Conclusions:Infant weight and weight gain are associated with obesity in childhood already during the first months of life. Determinants of weight gain shortly after birth may be a suitable target for prevention of obesity.",

keywords = "Adult, Age of Onset, Body Weight, Breast Feeding, Case-Control Studies, Cohort Studies, Denmark, Epigenomics, European Continental Ancestry Group, Female, Humans, Infant, Infant Formula, Infant Nutritional Physiological Phenomena, Infant, Newborn, Male, Obesity, Odds Ratio, Predictive Value of Tests, Pregnancy, Weight Gain",

author = "Andersen, {Lise Geisler} and Claus Holst and Michaelsen, {Kim F.} and Baker, {J L} and S{\o}rensen, {Thorkild I.A.}",

note = "IHE 2012 057",

year = "2012",

month = oct,

doi = "10.1038/ijo.2012.134",

language = "English",

volume = "36",

pages = "1306--1311",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "nature publishing group",

number = "10",

}

TY - JOUR

T1 - Weight and weight gain during early infancy predict childhood obesity

T2 - a case-cohort study

AU - Andersen, Lise Geisler

AU - Holst, Claus

AU - Michaelsen, Kim F.

AU - Baker, J L

AU - Sørensen, Thorkild I.A.

N1 - IHE 2012 057

PY - 2012/10

Y1 - 2012/10

N2 - Background:Infant weight and weight gain are positively associated with later obesity, but whether there is a particular critical time during infancy remains uncertain.Objective:The aim was to investigate when and how weight and weight gain during infancy become associated with childhood obesity.Methods:In a cohort representing 28 340 children born from 1959–67 and measured in Copenhagen schools, 962 obese children (2007 World Health Organization criteria), were compared with a 5% randomly selected sub-cohort of 1417 children. Information on weight at birth, 2 weeks, 1, 2, 3, 4, 6 and 9 months was retrieved from health visitors’ records. Odds ratios and 95% confidence intervals (CI) for childhood obesity by tertiles of weight at each age and by change in tertiles of weight between two consecutive measurements were estimated using multivariate logistic regression with adjustment for indicators of socioeconomic status, preterm birth, and breastfeeding.Results:Compared with children in the middle weight-tertile, children with a weight in the upper tertile had a 1.36-fold (CI, 1.10–1.69) to 1.72-fold (CI, 1.36–2.18) higher risk of childhood obesity from birth through 9 months, whereas children in the lower weight-tertile had almost half the risk of obesity from 2 through 9 months. The risk of childhood obesity associated with change in weight-tertile in each interval was stable at ∼1.5-fold per weight-tertile increase throughout infancy.Conclusions:Infant weight and weight gain are associated with obesity in childhood already during the first months of life. Determinants of weight gain shortly after birth may be a suitable target for prevention of obesity.

AB - Background:Infant weight and weight gain are positively associated with later obesity, but whether there is a particular critical time during infancy remains uncertain.Objective:The aim was to investigate when and how weight and weight gain during infancy become associated with childhood obesity.Methods:In a cohort representing 28 340 children born from 1959–67 and measured in Copenhagen schools, 962 obese children (2007 World Health Organization criteria), were compared with a 5% randomly selected sub-cohort of 1417 children. Information on weight at birth, 2 weeks, 1, 2, 3, 4, 6 and 9 months was retrieved from health visitors’ records. Odds ratios and 95% confidence intervals (CI) for childhood obesity by tertiles of weight at each age and by change in tertiles of weight between two consecutive measurements were estimated using multivariate logistic regression with adjustment for indicators of socioeconomic status, preterm birth, and breastfeeding.Results:Compared with children in the middle weight-tertile, children with a weight in the upper tertile had a 1.36-fold (CI, 1.10–1.69) to 1.72-fold (CI, 1.36–2.18) higher risk of childhood obesity from birth through 9 months, whereas children in the lower weight-tertile had almost half the risk of obesity from 2 through 9 months. The risk of childhood obesity associated with change in weight-tertile in each interval was stable at ∼1.5-fold per weight-tertile increase throughout infancy.Conclusions:Infant weight and weight gain are associated with obesity in childhood already during the first months of life. Determinants of weight gain shortly after birth may be a suitable target for prevention of obesity.

KW - Adult

KW - Age of Onset

KW - Body Weight

KW - Breast Feeding

KW - Case-Control Studies

KW - Cohort Studies

KW - Denmark

KW - Epigenomics

KW - European Continental Ancestry Group

KW - Female

KW - Humans

KW - Infant

KW - Infant Formula

KW - Infant Nutritional Physiological Phenomena

KW - Infant, Newborn

KW - Male

KW - Obesity

KW - Odds Ratio

KW - Predictive Value of Tests

KW - Pregnancy

KW - Weight Gain

U2 - 10.1038/ijo.2012.134

DO - 10.1038/ijo.2012.134

M3 - Journal article

C2 - 22907690

SN - 0307-0565

VL - 36

SP - 1306

EP - 1311

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 10

ER -

Weight and weight gain during early infancy predict childhood obesity: a case-cohort study

Abstract

Keywords

UN SDGs

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