von Willebrand Factor and Prekallikrein in Plasma Are Associated With Thrombus Volume in Abdominal Aortic Aneurysms

Qasam M Ghulam; Kim Bredahl; Jørgen Brodersen Gram; Lars Birger Lönn; Jens Peter Gøtze; Henrik Hegaard Sillesen; Jonas Peter Eiberg

doi:10.1177/1538574416666224

von Willebrand Factor and Prekallikrein in Plasma Are Associated With Thrombus Volume in Abdominal Aortic Aneurysms

Qasam M Ghulam, Kim Bredahl, Jørgen Brodersen Gram, Lars Birger Lönn, Jens Peter Gøtze, Henrik Hegaard Sillesen, Jonas Peter Eiberg

Department of Clinical Medicine

2 Citations (Scopus)

Abstract

Objectives: Disruption of the endothelial lining may be one of the events linking intraluminal thrombus and abdominal aortic aneurysm growth. In the present study, we examined whether von Willebrand factor activity in plasma, contact proteins of blood coagulation, and inflammatory biomarkers may be associated with intraluminal thrombus volume in search of a biochemical marker of endothelial damage and thrombus size. Design: Prospective study, correlating potential endothelial biomarkers and intraluminal thrombus volume acquired by computed tomography angiography. Materials and Methods: Plasma was consecutively obtained from 38 patients with asymptomatic infrarenal abdominal aortic aneurysm. von Willebrand factor activity, thrombin generation time, factor XII, and prekallikrein concentration were measured in plasma on automated and in-house platforms. In total, 8 patients were excluded due to ongoing anticoagulant therapy, renal impairment, or nonappearance, thus leaving 30 patients for further analysis. All patients had computed tomography angiography, and intraluminal volume was quantified off-line by OsiriX 6.5. Results: Median intraluminal thrombus volume was 42.7 mL. Spearman correlation analysis revealed a positive correlation between thrombus volume, von Willebrand factor activity (I = 0.56, P =.0013), and prekallikrein concentration in plasma (I = 0.54, P =.002). Conclusion: von Willebrand factor activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.

Original language	English
Journal	Vascular and Endovascular Surgery
Volume	50
Issue number	6
Pages (from-to)	391-397
Number of pages	7
ISSN	1538-5744
DOIs	https://doi.org/10.1177/1538574416666224
Publication status	Published - 1 Aug 2016

Keywords

Aged
Aortic Aneurysm, Abdominal
Aortography
Asymptomatic Diseases
Biomarkers
Blood Coagulation
Computed Tomography Angiography
Female
Humans
Male
Multidetector Computed Tomography
Predictive Value of Tests
Prekallikrein
Prognosis
Prospective Studies
Thrombin Time
Thrombosis
von Willebrand Factor
Journal Article

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10.1177/1538574416666224

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title = "von Willebrand Factor and Prekallikrein in Plasma Are Associated With Thrombus Volume in Abdominal Aortic Aneurysms",

abstract = "Objectives: Disruption of the endothelial lining may be one of the events linking intraluminal thrombus and abdominal aortic aneurysm growth. In the present study, we examined whether von Willebrand factor activity in plasma, contact proteins of blood coagulation, and inflammatory biomarkers may be associated with intraluminal thrombus volume in search of a biochemical marker of endothelial damage and thrombus size. Design: Prospective study, correlating potential endothelial biomarkers and intraluminal thrombus volume acquired by computed tomography angiography. Materials and Methods: Plasma was consecutively obtained from 38 patients with asymptomatic infrarenal abdominal aortic aneurysm. von Willebrand factor activity, thrombin generation time, factor XII, and prekallikrein concentration were measured in plasma on automated and in-house platforms. In total, 8 patients were excluded due to ongoing anticoagulant therapy, renal impairment, or nonappearance, thus leaving 30 patients for further analysis. All patients had computed tomography angiography, and intraluminal volume was quantified off-line by OsiriX 6.5. Results: Median intraluminal thrombus volume was 42.7 mL. Spearman correlation analysis revealed a positive correlation between thrombus volume, von Willebrand factor activity (I = 0.56, P =.0013), and prekallikrein concentration in plasma (I = 0.54, P =.002). Conclusion: von Willebrand factor activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.",

keywords = "Aged, Aortic Aneurysm, Abdominal, Aortography, Asymptomatic Diseases, Biomarkers, Blood Coagulation, Computed Tomography Angiography, Female, Humans, Male, Multidetector Computed Tomography, Predictive Value of Tests, Prekallikrein, Prognosis, Prospective Studies, Thrombin Time, Thrombosis, von Willebrand Factor, Journal Article",

author = "Ghulam, {Qasam M} and Kim Bredahl and Gram, {J{\o}rgen Brodersen} and L{\"o}nn, {Lars Birger} and G{\o}tze, {Jens Peter} and Sillesen, {Henrik Hegaard} and Eiberg, {Jonas Peter}",

note = "{\textcopyright} The Author(s) 2016.",

year = "2016",

month = aug,

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doi = "10.1177/1538574416666224",

language = "English",

volume = "50",

pages = "391--397",

journal = "Vascular and Endovascular Surgery",

issn = "1538-5744",

publisher = "SAGE Publications",

number = "6",

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TY - JOUR

T1 - von Willebrand Factor and Prekallikrein in Plasma Are Associated With Thrombus Volume in Abdominal Aortic Aneurysms

AU - Ghulam, Qasam M

AU - Bredahl, Kim

AU - Gram, Jørgen Brodersen

AU - Lönn, Lars Birger

AU - Gøtze, Jens Peter

AU - Sillesen, Henrik Hegaard

AU - Eiberg, Jonas Peter

N1 - © The Author(s) 2016.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Objectives: Disruption of the endothelial lining may be one of the events linking intraluminal thrombus and abdominal aortic aneurysm growth. In the present study, we examined whether von Willebrand factor activity in plasma, contact proteins of blood coagulation, and inflammatory biomarkers may be associated with intraluminal thrombus volume in search of a biochemical marker of endothelial damage and thrombus size. Design: Prospective study, correlating potential endothelial biomarkers and intraluminal thrombus volume acquired by computed tomography angiography. Materials and Methods: Plasma was consecutively obtained from 38 patients with asymptomatic infrarenal abdominal aortic aneurysm. von Willebrand factor activity, thrombin generation time, factor XII, and prekallikrein concentration were measured in plasma on automated and in-house platforms. In total, 8 patients were excluded due to ongoing anticoagulant therapy, renal impairment, or nonappearance, thus leaving 30 patients for further analysis. All patients had computed tomography angiography, and intraluminal volume was quantified off-line by OsiriX 6.5. Results: Median intraluminal thrombus volume was 42.7 mL. Spearman correlation analysis revealed a positive correlation between thrombus volume, von Willebrand factor activity (I = 0.56, P =.0013), and prekallikrein concentration in plasma (I = 0.54, P =.002). Conclusion: von Willebrand factor activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.

AB - Objectives: Disruption of the endothelial lining may be one of the events linking intraluminal thrombus and abdominal aortic aneurysm growth. In the present study, we examined whether von Willebrand factor activity in plasma, contact proteins of blood coagulation, and inflammatory biomarkers may be associated with intraluminal thrombus volume in search of a biochemical marker of endothelial damage and thrombus size. Design: Prospective study, correlating potential endothelial biomarkers and intraluminal thrombus volume acquired by computed tomography angiography. Materials and Methods: Plasma was consecutively obtained from 38 patients with asymptomatic infrarenal abdominal aortic aneurysm. von Willebrand factor activity, thrombin generation time, factor XII, and prekallikrein concentration were measured in plasma on automated and in-house platforms. In total, 8 patients were excluded due to ongoing anticoagulant therapy, renal impairment, or nonappearance, thus leaving 30 patients for further analysis. All patients had computed tomography angiography, and intraluminal volume was quantified off-line by OsiriX 6.5. Results: Median intraluminal thrombus volume was 42.7 mL. Spearman correlation analysis revealed a positive correlation between thrombus volume, von Willebrand factor activity (I = 0.56, P =.0013), and prekallikrein concentration in plasma (I = 0.54, P =.002). Conclusion: von Willebrand factor activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.

KW - Aged

KW - Aortic Aneurysm, Abdominal

KW - Aortography

KW - Asymptomatic Diseases

KW - Biomarkers

KW - Blood Coagulation

KW - Computed Tomography Angiography

KW - Female

KW - Humans

KW - Male

KW - Multidetector Computed Tomography

KW - Predictive Value of Tests

KW - Prekallikrein

KW - Prognosis

KW - Prospective Studies

KW - Thrombin Time

KW - Thrombosis

KW - von Willebrand Factor

KW - Journal Article

U2 - 10.1177/1538574416666224

DO - 10.1177/1538574416666224

M3 - Journal article

C2 - 27581227

SN - 1538-5744

VL - 50

SP - 391

EP - 397

JO - Vascular and Endovascular Surgery

JF - Vascular and Endovascular Surgery

IS - 6

ER -

von Willebrand Factor and Prekallikrein in Plasma Are Associated With Thrombus Volume in Abdominal Aortic Aneurysms

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