Abstract
OBJECTIVES: Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the association between vitamin D status and prevalent and incident COPD in the general population.
METHODS: We included a total of 12,041 individuals from three general population studies conducted in 1993-94, 1999-2001, and 2006-2008, respectively, with vitamin D measurements. Information on COPD was obtained from the Danish National Patient Register and The Danish Registry of Causes of Death.
RESULTS: There were 85 prevalent and 463 incident cases of COPD (median follow-up 9.7 years). We found a statistically significant inverse association between vitamin D status and prevalent COPD with odds ratio = 0.89 (95% confidence interval, CI: 0.79, 1.0), but no statistically significant association with incident COPD with a hazard ratio = 0.98 (95% CI: 0.94, 1.0), respectively, per 10 nmol/l higher vitamin D status, when adjusted for possible confounders.
CONCLUSIONS: We found a statistically significant inverse cross-sectional association between vitamin D status and COPD, but no association between vitamin D status and incident COPD.
| Original language | English |
|---|---|
| Article number | e90654 |
| Journal | PloS one |
| Volume | 9 |
| Issue number | 3 |
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - 4 Mar 2014 |
Keywords
- Adolescent
- Adult
- Aged
- Cross-Sectional Studies
- Denmark
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Prevalence
- Proportional Hazards Models
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
- Risk Factors
- Vitamin D
- Vitamin D Deficiency
- Young Adult