Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark

Nina Weis; Susan Cowan; Sofie Hallager; Sandra Dröse; Lena Hagelskjær Kristensen; Karin Grønbæk; Janne Jensen; Jan Gerstoft; Lone G Madsen; Mette Rye Clausen; Suzanne Lunding; Britta D Tarp; Toke S Barfod; Stine Sloth; Dorte Kinggaard Holm; Jesper Jensen; Henrik Krarup

doi:10.1080/00365521.2016.1244704

Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark

Nina Weis, Susan Cowan, Sofie Hallager, Sandra Dröse, Lena Hagelskjær Kristensen, Karin Grønbæk, Janne Jensen, Jan Gerstoft, Lone G Madsen, Mette Rye Clausen, Suzanne Lunding, Britta D Tarp, Toke S Barfod, Stine Sloth, Dorte Kinggaard Holm, Jesper Jensen, Henrik Krarup

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission.

MATERIALS AND METHODS: Through the Danish Database for Hepatitis B and C, we identified 589 HBV-infected women who had given birth to 686 children, of whom 370 children were born to 322 women referred to hospital. 132 (36%) children, born to 109 mothers, were included in the study; 128 children had blood samples tested for HBsAg, anti-HBc (total), anti-HBs and HBV-DNA and four children had saliva samples tested for anti-HBc.

RESULTS: We found vertical HBV transmission in Denmark to be 2.3% [95% CI: 0.5, 6.5], a high proportion of HBsAg-negative children with low levels of anti-HBs (18.4%) and a high proportion (15.2%) with resolved HBV infection. No maternal risk factor was statistically significantly associated with HBV vertical transmission.

CONCLUSION: In a HBV low prevalence setting as Denmark, despite a national vaccination program, vertical HBV transmission occurred in 2.3% of children born to HBV-infected mothers. In addition, a high proportion of the children had insufficient anti-HBs levels and a high proportion had serological signs of resolved HBV infection.

Original language	English
Book series	Scandinavian Journal of Gastroenterology
Volume	52
Issue number	2
Pages (from-to)	178-184
Number of pages	7
ISSN	0085-5928
DOIs	https://doi.org/10.1080/00365521.2016.1244704
Publication status	Published - 1 Feb 2017

Keywords

Adolescent
Adult
Child
Child, Preschool
DNA, Viral
Databases, Factual
Denmark
Female
Hepatitis B Antibodies
Hepatitis B Antigens
Hepatitis B virus
Hepatitis B, Chronic
Humans
Infant
Infectious Disease Transmission, Vertical
Logistic Models
Male
Mass Screening
Pregnancy
Risk Factors
Vaccination
Young Adult
Journal Article
Multicenter Study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/00365521.2016.1244704

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Weis, N., Cowan, S., Hallager, S., Dröse, S., Kristensen, L. H., Grønbæk, K., Jensen, J., Gerstoft, J., Madsen, L. G., Clausen, M. R., Lunding, S., Tarp, B. D., Barfod, T. S., Sloth, S., Holm, D. K., Jensen, J., & Krarup, H. (2017). Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark. Scandinavian Journal of Gastroenterology, 52(2), 178-184. https://doi.org/10.1080/00365521.2016.1244704

Weis, N, Cowan, S, Hallager, S, Dröse, S, Kristensen, LH, Grønbæk, K, Jensen, J, Gerstoft, J , Madsen, LG, Clausen, MR, Lunding, S, Tarp, BD, Barfod, TS, Sloth, S, Holm, DK, Jensen, J & Krarup, H 2017, 'Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark', Scandinavian Journal of Gastroenterology, vol. 52, no. 2, pp. 178-184. https://doi.org/10.1080/00365521.2016.1244704

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abstract = "OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission.MATERIALS AND METHODS: Through the Danish Database for Hepatitis B and C, we identified 589 HBV-infected women who had given birth to 686 children, of whom 370 children were born to 322 women referred to hospital. 132 (36%) children, born to 109 mothers, were included in the study; 128 children had blood samples tested for HBsAg, anti-HBc (total), anti-HBs and HBV-DNA and four children had saliva samples tested for anti-HBc.RESULTS: We found vertical HBV transmission in Denmark to be 2.3% [95% CI: 0.5, 6.5], a high proportion of HBsAg-negative children with low levels of anti-HBs (18.4%) and a high proportion (15.2%) with resolved HBV infection. No maternal risk factor was statistically significantly associated with HBV vertical transmission.CONCLUSION: In a HBV low prevalence setting as Denmark, despite a national vaccination program, vertical HBV transmission occurred in 2.3% of children born to HBV-infected mothers. In addition, a high proportion of the children had insufficient anti-HBs levels and a high proportion had serological signs of resolved HBV infection.",

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author = "Nina Weis and Susan Cowan and Sofie Hallager and Sandra Dr{\"o}se and Kristensen, {Lena Hagelskj{\ae}r} and Karin Gr{\o}nb{\ae}k and Janne Jensen and Jan Gerstoft and Madsen, {Lone G} and Clausen, {Mette Rye} and Suzanne Lunding and Tarp, {Britta D} and Barfod, {Toke S} and Stine Sloth and Holm, {Dorte Kinggaard} and Jesper Jensen and Henrik Krarup",

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doi = "10.1080/00365521.2016.1244704",

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T1 - Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark

AU - Weis, Nina

AU - Cowan, Susan

AU - Hallager, Sofie

AU - Dröse, Sandra

AU - Kristensen, Lena Hagelskjær

AU - Grønbæk, Karin

AU - Jensen, Janne

AU - Gerstoft, Jan

AU - Madsen, Lone G

AU - Clausen, Mette Rye

AU - Lunding, Suzanne

AU - Tarp, Britta D

AU - Barfod, Toke S

AU - Sloth, Stine

AU - Holm, Dorte Kinggaard

AU - Jensen, Jesper

AU - Krarup, Henrik

PY - 2017/2/1

Y1 - 2017/2/1

N2 - OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission.MATERIALS AND METHODS: Through the Danish Database for Hepatitis B and C, we identified 589 HBV-infected women who had given birth to 686 children, of whom 370 children were born to 322 women referred to hospital. 132 (36%) children, born to 109 mothers, were included in the study; 128 children had blood samples tested for HBsAg, anti-HBc (total), anti-HBs and HBV-DNA and four children had saliva samples tested for anti-HBc.RESULTS: We found vertical HBV transmission in Denmark to be 2.3% [95% CI: 0.5, 6.5], a high proportion of HBsAg-negative children with low levels of anti-HBs (18.4%) and a high proportion (15.2%) with resolved HBV infection. No maternal risk factor was statistically significantly associated with HBV vertical transmission.CONCLUSION: In a HBV low prevalence setting as Denmark, despite a national vaccination program, vertical HBV transmission occurred in 2.3% of children born to HBV-infected mothers. In addition, a high proportion of the children had insufficient anti-HBs levels and a high proportion had serological signs of resolved HBV infection.

AB - OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission.MATERIALS AND METHODS: Through the Danish Database for Hepatitis B and C, we identified 589 HBV-infected women who had given birth to 686 children, of whom 370 children were born to 322 women referred to hospital. 132 (36%) children, born to 109 mothers, were included in the study; 128 children had blood samples tested for HBsAg, anti-HBc (total), anti-HBs and HBV-DNA and four children had saliva samples tested for anti-HBc.RESULTS: We found vertical HBV transmission in Denmark to be 2.3% [95% CI: 0.5, 6.5], a high proportion of HBsAg-negative children with low levels of anti-HBs (18.4%) and a high proportion (15.2%) with resolved HBV infection. No maternal risk factor was statistically significantly associated with HBV vertical transmission.CONCLUSION: In a HBV low prevalence setting as Denmark, despite a national vaccination program, vertical HBV transmission occurred in 2.3% of children born to HBV-infected mothers. In addition, a high proportion of the children had insufficient anti-HBs levels and a high proportion had serological signs of resolved HBV infection.

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KW - Hepatitis B Antigens

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KW - Hepatitis B, Chronic

KW - Humans

KW - Infant

KW - Infectious Disease Transmission, Vertical

KW - Logistic Models

KW - Male

KW - Mass Screening

KW - Pregnancy

KW - Risk Factors

KW - Vaccination

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DO - 10.1080/00365521.2016.1244704

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JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

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ER -

Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark

Abstract

Keywords

UN SDGs

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