Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction

TY - JOUR

T1 - Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction

AU - Dose, Nynne

AU - Michelsen, Marie Mide

AU - Mygind, Naja Dam

AU - Pena, Adam

AU - Ellervik, Christina

AU - Hansen, Peter R

AU - Kanters, Jørgen K

AU - Prescott, Eva

AU - Kastrup, Jens

AU - Steering Committee of the iPOWER study

AU - Gustafsson, Ida

AU - Hansen, Henrik Steen

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2018/1

Y1 - 2018/1

N2 - Objectives: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD. Methods: Women with angina pectoris and no obstructive coronary artery disease (n = 138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography. Results: Women with angina pectoris had significantly longer QTc intervals (429 ± 20 ms) and increased MCS (IQR) (0.73 [0.64–0.80]) compared with the controls (419 ± 20 ms) and (0.63 [(0.53–0.73]), respectively (both p < 0.001). CFVR was associated with longer QTc interval (p = 0.02), but the association was attenuated after multivariable adjustment (p = 0.08). Conclusion: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.

AB - Objectives: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD. Methods: Women with angina pectoris and no obstructive coronary artery disease (n = 138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography. Results: Women with angina pectoris had significantly longer QTc intervals (429 ± 20 ms) and increased MCS (IQR) (0.73 [0.64–0.80]) compared with the controls (419 ± 20 ms) and (0.63 [(0.53–0.73]), respectively (both p < 0.001). CFVR was associated with longer QTc interval (p = 0.02), but the association was attenuated after multivariable adjustment (p = 0.08). Conclusion: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.

KW - Journal Article

U2 - 10.1016/j.jelectrocard.2017.08.017

DO - 10.1016/j.jelectrocard.2017.08.017

M3 - Journal article

C2 - 28939174

SN - 0022-0736

VL - 51

SP - 15

EP - 20

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 1

ER -