Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people

N Grarup; A Albrechtsen; J Ek; K Borch-Johnsen; T Jørgensen; Ole Schmitz; T Hansen; O Pedersen

doi:10.1007/s00125-007-0668-2

Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people

N Grarup, A Albrechtsen, J Ek, K Borch-Johnsen, T Jørgensen, Ole Schmitz, T Hansen, O Pedersen

Computational and RNA Biology

30 Citations (Scopus)

Abstract

Studies in animals reveal that peroxisome proliferator-activated receptor delta (PPARdelta) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits.

Original language	English
Journal	Diabetologia
Volume	50
Issue number	6
Pages (from-to)	1201-8
Number of pages	8
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-007-0668-2
Publication status	Published - Jun 2007

Keywords

Adult
DNA Mutational Analysis
Diabetes Mellitus, Type 2
European Continental Ancestry Group
Female
Genetic Variation
Genome
Glucose
Humans
Lipids
Liver
Male
Middle Aged
Muscle, Skeletal
PPAR delta
Polymorphism, Genetic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-007-0668-2

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title = "Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people",

abstract = "Studies in animals reveal that peroxisome proliferator-activated receptor delta (PPARdelta) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits.",

keywords = "Adult, DNA Mutational Analysis, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Variation, Genome, Glucose, Humans, Lipids, Liver, Male, Middle Aged, Muscle, Skeletal, PPAR delta, Polymorphism, Genetic",

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T1 - Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people

AU - Grarup, N

AU - Albrechtsen, A

AU - Ek, J

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Schmitz, Ole

AU - Hansen, T

AU - Pedersen, O

PY - 2007/6

Y1 - 2007/6

N2 - Studies in animals reveal that peroxisome proliferator-activated receptor delta (PPARdelta) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits.

AB - Studies in animals reveal that peroxisome proliferator-activated receptor delta (PPARdelta) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits.

KW - Adult

KW - DNA Mutational Analysis

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Variation

KW - Genome

KW - Glucose

KW - Humans

KW - Lipids

KW - Liver

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal

KW - PPAR delta

KW - Polymorphism, Genetic

U2 - 10.1007/s00125-007-0668-2

DO - 10.1007/s00125-007-0668-2

M3 - Journal article

C2 - 17431579

SN - 0012-186X

VL - 50

SP - 1201

EP - 1208

JO - Diabetologia

JF - Diabetologia

IS - 6

ER -

Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people

Abstract

Keywords

UN SDGs

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