VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

Pamela Magistrado; Ali Salanti; Nicaise G Tuikue Ndam; Steven B Mwakalinga; Mafalda Resende; Madeleine Dahlbäck; Lars Hviid; John Lusingu; Thor G Theander; Morten A Nielsen

doi:10.1086/591502

VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

Pamela Magistrado, Ali Salanti, Nicaise G Tuikue Ndam, Steven B Mwakalinga, Mafalda Resende, Madeleine Dahlbäck, Lars Hviid, John Lusingu, Thor G Theander, Morten A Nielsen

47 Citations (Scopus)

Abstract

Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. Both placental and chondroitin sulphate A-selected parasites have high-level transcripts of a unique var gene named var2csa. However, VAR2CSA has not been consistently found by proteomic analysis of placental parasites. Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA.

Original language	English
Journal	Journal of Infectious Diseases
ISSN	0022-1899
DOIs	https://doi.org/10.1086/591502
Publication status	Published - 2008

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title = "VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes",

abstract = "Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. Both placental and chondroitin sulphate A-selected parasites have high-level transcripts of a unique var gene named var2csa. However, VAR2CSA has not been consistently found by proteomic analysis of placental parasites. Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA.",

author = "Pamela Magistrado and Ali Salanti and {Tuikue Ndam}, {Nicaise G} and Mwakalinga, {Steven B} and Mafalda Resende and Madeleine Dahlb{\"a}ck and Lars Hviid and John Lusingu and Theander, {Thor G} and Nielsen, {Morten A}",

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doi = "10.1086/591502",

language = "English",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

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TY - JOUR

T1 - VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

AU - Magistrado, Pamela

AU - Salanti, Ali

AU - Tuikue Ndam, Nicaise G

AU - Mwakalinga, Steven B

AU - Resende, Mafalda

AU - Dahlbäck, Madeleine

AU - Hviid, Lars

AU - Lusingu, John

AU - Theander, Thor G

AU - Nielsen, Morten A

PY - 2008

Y1 - 2008

N2 - Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. Both placental and chondroitin sulphate A-selected parasites have high-level transcripts of a unique var gene named var2csa. However, VAR2CSA has not been consistently found by proteomic analysis of placental parasites. Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA.

AB - Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. Both placental and chondroitin sulphate A-selected parasites have high-level transcripts of a unique var gene named var2csa. However, VAR2CSA has not been consistently found by proteomic analysis of placental parasites. Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA.

U2 - 10.1086/591502

DO - 10.1086/591502

M3 - Journal article

C2 - 18700835

SN - 0022-1899

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

ER -

VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

Abstract

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