Validity and reliability of 3D US for the detection of erosions in patients with rheumatoid arthritis using MRI as the gold standard

K Ellegaard; H Bliddal; U Møller Døhn; M Henriksen; M Boesen; Rasmus Bouert; B Danneskiold-Samsøe; S Torp-Pedersen

doi:10.1055/s-0032-1330348

Validity and reliability of 3D US for the detection of erosions in patients with rheumatoid arthritis using MRI as the gold standard

K Ellegaard, H Bliddal, U Møller Døhn, M Henriksen, M Boesen, Rasmus Bouert, B Danneskiold-Samsøe, S Torp-Pedersen

Department of Clinical Medicine

6 Citations (Scopus)

Abstract

Purpose: To test the reliability and validity of a 3D US erosion score in RA using MRI as the gold standard. Materials and Methods: RA patients were examined with 3D US and 3T MRI over the 2^nd and 3^rd metacarpophalangeal joints. 3D blocks were evaluated by two investigators. The erosions were estimated according to a semi-quantitative score (SQS) (0-3) and a quantitative score (QS) (mm²). MRI was evaluated according to the RAMRIS score. For the estimation of reliability, intra-class correlation coefficients (ICC) were used. Validity was tested using Spearman's rho (r_s). The sensitivity and specificity were also calculated. Results: 28 patients with RA were included. The ICC for the inter-observer reliability in the QS was 0.41 and 0.13 for the metacarpal bone and phalangeal bone, respectively, and 0.86 and 0.16, respectively, in the SQS.The ICC for the intra-observer reliability in the QS was 0.75 and 0.48 for the metacarpal bone and phalangeal bone, respectively, and 0.83 and 0.60, respectively, in the SQS.The correlation with MRI for the metacarpal bone was significant, with values of 0.73 (p=0.0001) (SQ) and 0.74 (p=0.0001) (SQS). For the phalangeal bone, bad correlation was found: 0.28 (p=0.145) (SQ) and 0.26 (p=0.57) (SQS). The sensitivity and specificity for the metacarpal bone were 86% and 85% respectively. For the phalangeal bone they were 60% and 97%, respectively. Conclusion: Good inter- and intra-observer reliability and correlation with MRI were seen in the assessment of erosions with 3D US in the metacarpal bone, while the results were low and insignificant for the phalangeal bone, indicating that 3D US still has room for improvement.

Original language	English
Journal	Ultraschall in der Medizin
Volume	35
Issue number	2
Pages (from-to)	137-141
Number of pages	5
ISSN	0172-4614
DOIs	https://doi.org/10.1055/s-0032-1330348
Publication status	Published - Apr 2014

Keywords

Adult
Aged
Aged, 80 and over
Cohort Studies
Female
Finger Phalanges
Humans
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Male
Metacarpal Bones
Metacarpophalangeal Joint
Middle Aged
Observer Variation
Reference Values
Sensitivity and Specificity
Statistics as Topic
Ultrasonography
Young Adult

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10.1055/s-0032-1330348

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@article{d2133a8edf8f479aaa6c96cecf803316,

title = "Validity and reliability of 3D US for the detection of erosions in patients with rheumatoid arthritis using MRI as the gold standard",

abstract = "Purpose: To test the reliability and validity of a 3D US erosion score in RA using MRI as the gold standard. Materials and Methods: RA patients were examined with 3D US and 3T MRI over the 2nd and 3rd metacarpophalangeal joints. 3D blocks were evaluated by two investigators. The erosions were estimated according to a semi-quantitative score (SQS) (0-3) and a quantitative score (QS) (mm2). MRI was evaluated according to the RAMRIS score. For the estimation of reliability, intra-class correlation coefficients (ICC) were used. Validity was tested using Spearman's rho (rs). The sensitivity and specificity were also calculated. Results: 28 patients with RA were included. The ICC for the inter-observer reliability in the QS was 0.41 and 0.13 for the metacarpal bone and phalangeal bone, respectively, and 0.86 and 0.16, respectively, in the SQS.The ICC for the intra-observer reliability in the QS was 0.75 and 0.48 for the metacarpal bone and phalangeal bone, respectively, and 0.83 and 0.60, respectively, in the SQS.The correlation with MRI for the metacarpal bone was significant, with values of 0.73 (p=0.0001) (SQ) and 0.74 (p=0.0001) (SQS). For the phalangeal bone, bad correlation was found: 0.28 (p=0.145) (SQ) and 0.26 (p=0.57) (SQS). The sensitivity and specificity for the metacarpal bone were 86% and 85% respectively. For the phalangeal bone they were 60% and 97%, respectively. Conclusion: Good inter- and intra-observer reliability and correlation with MRI were seen in the assessment of erosions with 3D US in the metacarpal bone, while the results were low and insignificant for the phalangeal bone, indicating that 3D US still has room for improvement.",

keywords = "Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Finger Phalanges, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Metacarpal Bones, Metacarpophalangeal Joint, Middle Aged, Observer Variation, Reference Values, Sensitivity and Specificity, Statistics as Topic, Ultrasonography, Young Adult",

author = "K Ellegaard and H Bliddal and {M{\o}ller D{\o}hn}, U and M Henriksen and M Boesen and Rasmus Bouert and B Danneskiold-Sams{\o}e and S Torp-Pedersen",

note = "{\textcopyright} Georg Thieme Verlag KG Stuttgart · New York.",

year = "2014",

month = apr,

doi = "10.1055/s-0032-1330348",

language = "English",

volume = "35",

pages = "137--141",

journal = "Ultraschall in der Medizin",

issn = "0172-4614",

publisher = "GeorgThieme Verlag",

number = "2",

}

TY - JOUR

T1 - Validity and reliability of 3D US for the detection of erosions in patients with rheumatoid arthritis using MRI as the gold standard

AU - Ellegaard, K

AU - Bliddal, H

AU - Møller Døhn, U

AU - Henriksen, M

AU - Boesen, M

AU - Bouert, Rasmus

AU - Danneskiold-Samsøe, B

AU - Torp-Pedersen, S

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2014/4

Y1 - 2014/4

N2 - Purpose: To test the reliability and validity of a 3D US erosion score in RA using MRI as the gold standard. Materials and Methods: RA patients were examined with 3D US and 3T MRI over the 2nd and 3rd metacarpophalangeal joints. 3D blocks were evaluated by two investigators. The erosions were estimated according to a semi-quantitative score (SQS) (0-3) and a quantitative score (QS) (mm2). MRI was evaluated according to the RAMRIS score. For the estimation of reliability, intra-class correlation coefficients (ICC) were used. Validity was tested using Spearman's rho (rs). The sensitivity and specificity were also calculated. Results: 28 patients with RA were included. The ICC for the inter-observer reliability in the QS was 0.41 and 0.13 for the metacarpal bone and phalangeal bone, respectively, and 0.86 and 0.16, respectively, in the SQS.The ICC for the intra-observer reliability in the QS was 0.75 and 0.48 for the metacarpal bone and phalangeal bone, respectively, and 0.83 and 0.60, respectively, in the SQS.The correlation with MRI for the metacarpal bone was significant, with values of 0.73 (p=0.0001) (SQ) and 0.74 (p=0.0001) (SQS). For the phalangeal bone, bad correlation was found: 0.28 (p=0.145) (SQ) and 0.26 (p=0.57) (SQS). The sensitivity and specificity for the metacarpal bone were 86% and 85% respectively. For the phalangeal bone they were 60% and 97%, respectively. Conclusion: Good inter- and intra-observer reliability and correlation with MRI were seen in the assessment of erosions with 3D US in the metacarpal bone, while the results were low and insignificant for the phalangeal bone, indicating that 3D US still has room for improvement.

AB - Purpose: To test the reliability and validity of a 3D US erosion score in RA using MRI as the gold standard. Materials and Methods: RA patients were examined with 3D US and 3T MRI over the 2nd and 3rd metacarpophalangeal joints. 3D blocks were evaluated by two investigators. The erosions were estimated according to a semi-quantitative score (SQS) (0-3) and a quantitative score (QS) (mm2). MRI was evaluated according to the RAMRIS score. For the estimation of reliability, intra-class correlation coefficients (ICC) were used. Validity was tested using Spearman's rho (rs). The sensitivity and specificity were also calculated. Results: 28 patients with RA were included. The ICC for the inter-observer reliability in the QS was 0.41 and 0.13 for the metacarpal bone and phalangeal bone, respectively, and 0.86 and 0.16, respectively, in the SQS.The ICC for the intra-observer reliability in the QS was 0.75 and 0.48 for the metacarpal bone and phalangeal bone, respectively, and 0.83 and 0.60, respectively, in the SQS.The correlation with MRI for the metacarpal bone was significant, with values of 0.73 (p=0.0001) (SQ) and 0.74 (p=0.0001) (SQS). For the phalangeal bone, bad correlation was found: 0.28 (p=0.145) (SQ) and 0.26 (p=0.57) (SQS). The sensitivity and specificity for the metacarpal bone were 86% and 85% respectively. For the phalangeal bone they were 60% and 97%, respectively. Conclusion: Good inter- and intra-observer reliability and correlation with MRI were seen in the assessment of erosions with 3D US in the metacarpal bone, while the results were low and insignificant for the phalangeal bone, indicating that 3D US still has room for improvement.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Cohort Studies

KW - Female

KW - Finger Phalanges

KW - Humans

KW - Imaging, Three-Dimensional

KW - Magnetic Resonance Imaging

KW - Male

KW - Metacarpal Bones

KW - Metacarpophalangeal Joint

KW - Middle Aged

KW - Observer Variation

KW - Reference Values

KW - Sensitivity and Specificity

KW - Statistics as Topic

KW - Ultrasonography

KW - Young Adult

U2 - 10.1055/s-0032-1330348

DO - 10.1055/s-0032-1330348

M3 - Journal article

C2 - 23696060

SN - 0172-4614

VL - 35

SP - 137

EP - 141

JO - Ultraschall in der Medizin

JF - Ultraschall in der Medizin

IS - 2

ER -

Validity and reliability of 3D US for the detection of erosions in patients with rheumatoid arthritis using MRI as the gold standard

Abstract

Keywords

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