USING OXYGEN-CONSUMING THERMOSET PLASTICS TO GENERATE HYPOXIC CONDITIONS IN MICROFLUIDIC DEVICES FOR POTENTIAL CELL CULTURE APPLICATIONS

Drago Sticker; Mario Rothbauer; Josef Ehgartner; Christoph  Steininger; Winfried Neuhaus; Torsten Mayr; Tommy Haraldsson; Jörg P. Kutter; Peter Ertl

Abstract

The precise control of the oxygen concentration in a cellular environment allows the study of cells under physiologically relevant conditions. This work reports on a novel method for the generation of reduced dissolved oxygen concentrations in microfluidic chambers for cell- and organ-on-chip applications. Using a thermoset polymeric material (OSTEMERTM), which effectively scavenges dissolved oxygen (DO), microfluidic devices have been fabricated where oxygen was rapidly depleted from the microfluidic chamber. It is shown that hypoxic and anaerobic conditions can be generated through the inherent scavenging property of the material itself, without any additional chemical additives.

Original language	English
Publication date	Oct 2017
Number of pages	2
Publication status	Published - Oct 2017
Event	The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017) - Savannah, Georgia, USA, Savannah, United States Duration: 22 Oct 2017 → 26 Oct 2017

Conference

Conference	The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
Location	Savannah, Georgia, USA
Country/Territory	United States
City	Savannah
Period	22/10/2017 → 26/10/2017

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Sticker, D., Rothbauer, M., Ehgartner, J., Steininger, C., Neuhaus, W., Mayr, T., Haraldsson, T., Kutter, J. P., & Ertl, P. (2017). USING OXYGEN-CONSUMING THERMOSET PLASTICS TO GENERATE HYPOXIC CONDITIONS IN MICROFLUIDIC DEVICES FOR POTENTIAL CELL CULTURE APPLICATIONS. Abstract from The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017) , Savannah, United States.

USING OXYGEN-CONSUMING THERMOSET PLASTICS TO GENERATE HYPOXIC CONDITIONS IN MICROFLUIDIC DEVICES FOR POTENTIAL CELL CULTURE APPLICATIONS. / Sticker, Drago; Rothbauer, Mario; Ehgartner, Josef et al.

2017. Abstract from The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017) , Savannah, United States.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Sticker, D, Rothbauer, M, Ehgartner, J, Steininger, C, Neuhaus, W, Mayr, T, Haraldsson, T, Kutter, JP & Ertl, P 2017, 'USING OXYGEN-CONSUMING THERMOSET PLASTICS TO GENERATE HYPOXIC CONDITIONS IN MICROFLUIDIC DEVICES FOR POTENTIAL CELL CULTURE APPLICATIONS', The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017) , Savannah, United States, 22/10/2017 - 26/10/2017.

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title = "USING OXYGEN-CONSUMING THERMOSET PLASTICS TO GENERATE HYPOXIC CONDITIONS IN MICROFLUIDIC DEVICES FOR POTENTIAL CELL CULTURE APPLICATIONS",

abstract = "The precise control of the oxygen concentration in a cellular environment allows the study of cells under physiologically relevant conditions. This work reports on a novel method for the generation of reduced dissolved oxygen concentrations in microfluidic chambers for cell- and organ-on-chip applications. Using a thermoset polymeric material (OSTEMERTM), which effectively scavenges dissolved oxygen (DO), microfluidic devices have been fabricated where oxygen was rapidly depleted from the microfluidic chamber. It is shown that hypoxic and anaerobic conditions can be generated through the inherent scavenging property of the material itself, without any additional chemical additives.",

author = "Drago Sticker and Mario Rothbauer and Josef Ehgartner and Christoph Steininger and Winfried Neuhaus and Torsten Mayr and Tommy Haraldsson and Kutter, {J{\"o}rg P.} and Peter Ertl",

year = "2017",

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AU - Sticker, Drago

AU - Rothbauer, Mario

AU - Ehgartner, Josef

AU - Steininger, Christoph

AU - Neuhaus, Winfried

AU - Mayr, Torsten

AU - Haraldsson, Tommy

AU - Kutter, Jörg P.

AU - Ertl, Peter

PY - 2017/10

Y1 - 2017/10

N2 - The precise control of the oxygen concentration in a cellular environment allows the study of cells under physiologically relevant conditions. This work reports on a novel method for the generation of reduced dissolved oxygen concentrations in microfluidic chambers for cell- and organ-on-chip applications. Using a thermoset polymeric material (OSTEMERTM), which effectively scavenges dissolved oxygen (DO), microfluidic devices have been fabricated where oxygen was rapidly depleted from the microfluidic chamber. It is shown that hypoxic and anaerobic conditions can be generated through the inherent scavenging property of the material itself, without any additional chemical additives.

AB - The precise control of the oxygen concentration in a cellular environment allows the study of cells under physiologically relevant conditions. This work reports on a novel method for the generation of reduced dissolved oxygen concentrations in microfluidic chambers for cell- and organ-on-chip applications. Using a thermoset polymeric material (OSTEMERTM), which effectively scavenges dissolved oxygen (DO), microfluidic devices have been fabricated where oxygen was rapidly depleted from the microfluidic chamber. It is shown that hypoxic and anaerobic conditions can be generated through the inherent scavenging property of the material itself, without any additional chemical additives.

UR - https://www.microtas2017.org/program/MicroTAS2017_FinalProgram.pdf

M3 - Conference abstract for conference

T2 - The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)

Y2 - 22 October 2017 through 26 October 2017

ER -

USING OXYGEN-CONSUMING THERMOSET PLASTICS TO GENERATE HYPOXIC CONDITIONS IN MICROFLUIDIC DEVICES FOR POTENTIAL CELL CULTURE APPLICATIONS

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