Use of nonsteroidal anti-inflammatory drugs prior to chronic renal replacement therapy initiation: a nationwide study

TY - JOUR

T1 - Use of nonsteroidal anti-inflammatory drugs prior to chronic renal replacement therapy initiation

T2 - a nationwide study

AU - Kristensen, Søren Lund

AU - Fosbøl, Emil L

AU - Kamper, Anne-Lise

AU - Køber, Lars

AU - Hommel, Kristine

AU - Lamberts, Morten

AU - Abildstrøm, Steen Z

AU - Blicher, Thalia M

AU - Torp-Pedersen, Christian

AU - Gislason, Gunnar H

AU - Kristensen, Søren Lund

N1 - Copyright © 2012 John Wiley & Sons, Ltd.

PY - 2012/4

Y1 - 2012/4

N2 - PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this study, we examined NSAID use, aetiology and comorbidity among a national cohort of patients before the initiation of chronic renal replacement therapy (RRT). METHODS: Patients initiated on chronic RRT in the period 1997-2006 were identified in the Danish National Registry on Regular Dialysis and Transplantation, including etiological diagnosis. The use of NSAID before the start of RRT was studied by linkage to the National Prescription Register and comorbidity by linkage to the National Patient Registry. RESULTS: A total of 6663 patients were included in the study, and 2407 patients (36.1%) were prescribed NSAID in the 3¿years before the start of RRT. These patients were older (mean age = 63.0 vs 61.4¿years) and had a significantly higher degree of comorbidity (Charlson score = 2.85 vs 2.61, p¿

AB - PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this study, we examined NSAID use, aetiology and comorbidity among a national cohort of patients before the initiation of chronic renal replacement therapy (RRT). METHODS: Patients initiated on chronic RRT in the period 1997-2006 were identified in the Danish National Registry on Regular Dialysis and Transplantation, including etiological diagnosis. The use of NSAID before the start of RRT was studied by linkage to the National Prescription Register and comorbidity by linkage to the National Patient Registry. RESULTS: A total of 6663 patients were included in the study, and 2407 patients (36.1%) were prescribed NSAID in the 3¿years before the start of RRT. These patients were older (mean age = 63.0 vs 61.4¿years) and had a significantly higher degree of comorbidity (Charlson score = 2.85 vs 2.61, p¿

U2 - 10.1002/pds.3227

DO - 10.1002/pds.3227

M3 - Journal article

C2 - 22344680

SN - 1053-8569

VL - 21

SP - 428

EP - 434

JO - Pharmacoepidemiology and Drug Safety

JF - Pharmacoepidemiology and Drug Safety

IS - 4

ER -