Use of molecular maging markers of glycolysis, hypoxia and proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a dog with fibrosarcoma: the importance of individualized treatment planning and monitoring

Kamilla Westarp Zornhagen; Malene Martini Clausen; Anders E. Hansen; Ian Law; Fintan McEvoy; Svend Aage Engelholm; Andreas Kjær; Annemarie Thuri Kristensen

doi:10.3390/diagnostics5030372

Use of molecular maging markers of glycolysis, hypoxia and proliferation (¹⁸F-FDG, ⁶⁴Cu-ATSM and ¹⁸F-FLT) in a dog with fibrosarcoma: the importance of individualized treatment planning and monitoring

Kamilla Westarp Zornhagen, Malene Martini Clausen, Anders E. Hansen, Ian Law, Fintan McEvoy, Svend Aage Engelholm, Andreas Kjær, Annemarie Thuri Kristensen

2 Citations (Scopus)

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Abstract

Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using ¹⁸F-FDG, ⁶⁴Cu-ATSM, and ¹⁸F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in ¹⁸F-FDG and ¹⁸F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.

Original language	English
Journal	Diagnostics
Volume	5
Issue number	3
Pages (from-to)	372-382
Number of pages	11
ISSN	2075-4418
DOIs	https://doi.org/10.3390/diagnostics5030372
Publication status	Published - 11 Sept 2015

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Use of molecular maging markers of glycolysis, hypoxia and proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a dog with fibrosarcomaFinal published version, 1.26 MB
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Zornhagen, K. W., Clausen, M. M., Hansen, A. E., Law, I., McEvoy, F., Engelholm, S. A., Kjær, A., & Kristensen, A. T. (2015). Use of molecular maging markers of glycolysis, hypoxia and proliferation (¹⁸F-FDG, ⁶⁴Cu-ATSM and ¹⁸F-FLT) in a dog with fibrosarcoma: the importance of individualized treatment planning and monitoring. Diagnostics, 5(3), 372-382. https://doi.org/10.3390/diagnostics5030372

Use of molecular maging markers of glycolysis, hypoxia and proliferation (¹⁸F-FDG, ⁶⁴Cu-ATSM and ¹⁸F-FLT) in a dog with fibrosarcoma: the importance of individualized treatment planning and monitoring. / Zornhagen, Kamilla Westarp ; Clausen, Malene Martini; Hansen, Anders E. et al.
In: Diagnostics, Vol. 5, No. 3, 11.09.2015, p. 372-382.

Research output: Contribution to journal › Journal article › Research › peer-review

Zornhagen, KW , Clausen, MM, Hansen, AE, Law, I , McEvoy, F, Engelholm, SA, Kjær, A & Kristensen, AT 2015, 'Use of molecular maging markers of glycolysis, hypoxia and proliferation (¹⁸F-FDG, ⁶⁴Cu-ATSM and ¹⁸F-FLT) in a dog with fibrosarcoma: the importance of individualized treatment planning and monitoring', Diagnostics, vol. 5, no. 3, pp. 372-382. https://doi.org/10.3390/diagnostics5030372

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abstract = "Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using 18F-FDG, 64Cu-ATSM, and 18F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in 18F-FDG and 18F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.",

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AB - Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using 18F-FDG, 64Cu-ATSM, and 18F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in 18F-FDG and 18F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.

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