Use of antibiotics in childhood and risk of Type 1 diabetes: a population-based case-control study

TY - JOUR

T1 - Use of antibiotics in childhood and risk of Type 1 diabetes

T2 - a population-based case-control study

AU - Mikkelsen, Kristian Hallundbæk

AU - Knop, F K

AU - Lauritsen, Tina Vilsbøll

AU - Frost, M

AU - Hallas, J

AU - Pottegård, A

N1 - This article is protected by copyright. All rights reserved.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Aims: To investigate whether the use of antibiotics from infancy to adolescence influences the risk of Type 1 diabetes. Methods: We conducted a population-based case–control study, including all Type 1 diabetes cases in Denmark among children born between 1997 and 2012 (n = 1578). Odds ratios associating Type 1 diabetes with use of antibiotics were calculated using conditional logistic regression. Results: Overall, we found no association between the use of antibiotics and risk of Type 1 diabetes. Furthermore, no associations were seen specifically for broad-spectrum, narrow-spectrum, bactericidal or bacteriostatic types of antibiotics or for the most frequently used individual classes of antibiotics. No differences were observed in subgroups defined by sex or by age at time of diagnosis. However, filling five or more antibiotic prescriptions in the first 2 years of life specifically was associated with a higher odds ratio of 1.35 (95% CI 1.10–1.64). This association appeared to be driven by exposure to broad-spectrum antibiotics within the second year of life. Conclusion: Antibiotic exposure in childhood is generally not associated with the risk of developing Type 1 diabetes. Future studies should investigate the effects of multiple exposures to broad-spectrum antibiotics during the second year of life.

AB - Aims: To investigate whether the use of antibiotics from infancy to adolescence influences the risk of Type 1 diabetes. Methods: We conducted a population-based case–control study, including all Type 1 diabetes cases in Denmark among children born between 1997 and 2012 (n = 1578). Odds ratios associating Type 1 diabetes with use of antibiotics were calculated using conditional logistic regression. Results: Overall, we found no association between the use of antibiotics and risk of Type 1 diabetes. Furthermore, no associations were seen specifically for broad-spectrum, narrow-spectrum, bactericidal or bacteriostatic types of antibiotics or for the most frequently used individual classes of antibiotics. No differences were observed in subgroups defined by sex or by age at time of diagnosis. However, filling five or more antibiotic prescriptions in the first 2 years of life specifically was associated with a higher odds ratio of 1.35 (95% CI 1.10–1.64). This association appeared to be driven by exposure to broad-spectrum antibiotics within the second year of life. Conclusion: Antibiotic exposure in childhood is generally not associated with the risk of developing Type 1 diabetes. Future studies should investigate the effects of multiple exposures to broad-spectrum antibiotics during the second year of life.

U2 - 10.1111/dme.13262

DO - 10.1111/dme.13262

M3 - Journal article

C2 - 27646695

SN - 0742-3071

VL - 34

SP - 272

EP - 277

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 2

ER -