Use and discontinuation of hormone replacement therapy in women with myocardial infarction: a nationwide study

Ditte-Marie Bretler, Peter Riis Hansen, Steen Zabell Abildstrøm, Casper Haslund Jørgensen, Rikke Sørensen, Morten Lock Hansen, Tina Ken Schramm, Ellen Løkkegaard, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Casper Haslund Jørgensen

    8 Citations (Scopus)

    Abstract

    AIM: To characterize the pattern of use and discontinuation of postmenopausal hormone replacement therapy (HRT) in women with myocardial infarction (MI) before and after 2002, where the general use of HRT dropped drastically subsequent to the results of the Women's Health Initiative trial. METHODS: All Danish women aged ≥40 years hospitalized with MI in the period 1997 to 2005 and their use of HRT were identified by individual-level-linkage of nationwide registers of hospitalization and drug dispensing from pharmacies. Characteristics associated with HRT use at time of MI and subsequent HRT discontinuation were analysed by multivariable logistic regression. RESULTS: In the study period, 34 778 women were discharged after MI. Of these, 3979 (11.4%) received HRT at the time of MI and their most used categories of HRT were vaginal oestrogen and oral oestrogen alone (46.6% and 28.7%, respectively). The percentage of women who continued HRT during the first year after discharge was 85.0% in the period 2000-2002 and had decreased to 79.6% in the period 2003-2005. Vaginal oestrogen use was associated with overall discontinuation of HRT (odds ratio [OR] 1.37, 95% confidence interval [CI] 1.10, 1.72), whereas use of oral oestrogen alone and use of oral cyclic combined oestrogen/progestogen were associated with change of HRT after MI (OR 2.33, 95% CI 1.10, 4.93 and OR 2.94, 95% CI 1.35, 6.39, respectively). CONCLUSION: The majority of women experiencing an MI during ongoing HRT continued HRT after discharge and this pattern of HRT use did not change markedly after 2002.

    Original languageEnglish
    JournalBritish Journal of Clinical Pharmacology
    Volume71
    Issue number1
    Pages (from-to)105-15
    Number of pages11
    ISSN0306-5251
    DOIs
    Publication statusPublished - 1 Jan 2011

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