Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases

Julie Gehl; Gregor Sersa; Louise Wichmann Matthiessen; Tobian Muir; Declan Soden; Antonio Occhini; Pietro Quaglino; Pietro Curatolo; Luca G. Campana; Christian Kunte; A. James P. Clover; Giulia Bertino; Victor Farricha; Joy Odili; Karin Dahlstrom; Marco Benazzo; Lluis M. Mir

doi:10.1080/0284186x.2018.1454602

Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases

Julie Gehl^*, Gregor Sersa, Louise Wichmann Matthiessen, Tobian Muir, Declan Soden, Antonio Occhini, Pietro Quaglino, Pietro Curatolo, Luca G. Campana, Christian Kunte, A. James P. Clover, Giulia Bertino, Victor Farricha, Joy Odili, Karin Dahlstrom, Marco Benazzo, Lluis M. Mir

^*Corresponding author for this work

Department of Clinical Medicine

103 Citations (Scopus)

Abstract

Electrochemotherapy is now in routine clinical use to treat cutaneous metastases of any histology, and is listed in national and international guidelines for cutaneous metastases and primary skin cancer. Electrochemotherapy is used by dermatologists, surgeons, and oncologists, and for different degrees and manifestations of metastases to skin and primary skin tumours not amenable to surgery. This treatment utilises electric pulses to permeabilize cell membranes in tumours, thus allowing a dramatic increase of the cytotoxicity of anti-cancer agents. Response rates, often after only one treatment, are very high across all tumour types. The most frequent indications are cutaneous metastases from malignant melanoma and breast cancer. In 2006, standard operating procedures (SOPs) were written for this novel technology, greatly facilitating introduction and dissemination of the therapy. Since then considerable experience has been obtained treating a wider range of tumour histologies and increasing size of tumours which was not originally thought possible. A pan-European expert panel drawn from a range of disciplines from dermatology, general surgery, head and neck surgery, plastic surgery, and oncology met to form a consensus opinion to update the SOPs based on the experience obtained. This paper contains these updated recommendations for indications for electrochemotherapy, pre-treatment information and evaluation, treatment choices, as well as follow-up.

Original language	English
Journal	Acta Oncologica
Volume	57
Issue number	7
Pages (from-to)	874-882
Number of pages	9
ISSN	0284-186X
DOIs	https://doi.org/10.1080/0284186x.2018.1454602
Publication status	Published - 2018

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Gehl, J., Sersa, G., Matthiessen, L. W., Muir, T., Soden, D., Occhini, A., Quaglino, P., Curatolo, P., Campana, L. G., Kunte, C., Clover, A. J. P., Bertino, G., Farricha, V., Odili, J., Dahlstrom, K., Benazzo, M., & Mir, L. M. (2018). Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases. Acta Oncologica, 57(7), 874-882. https://doi.org/10.1080/0284186x.2018.1454602

Gehl, J, Sersa, G, Matthiessen, LW, Muir, T, Soden, D, Occhini, A, Quaglino, P, Curatolo, P, Campana, LG, Kunte, C, Clover, AJP, Bertino, G, Farricha, V, Odili, J, Dahlstrom, K, Benazzo, M & Mir, LM 2018, 'Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases', Acta Oncologica, vol. 57, no. 7, pp. 874-882. https://doi.org/10.1080/0284186x.2018.1454602

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title = "Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases",

abstract = "Electrochemotherapy is now in routine clinical use to treat cutaneous metastases of any histology, and is listed in national and international guidelines for cutaneous metastases and primary skin cancer. Electrochemotherapy is used by dermatologists, surgeons, and oncologists, and for different degrees and manifestations of metastases to skin and primary skin tumours not amenable to surgery. This treatment utilises electric pulses to permeabilize cell membranes in tumours, thus allowing a dramatic increase of the cytotoxicity of anti-cancer agents. Response rates, often after only one treatment, are very high across all tumour types. The most frequent indications are cutaneous metastases from malignant melanoma and breast cancer. In 2006, standard operating procedures (SOPs) were written for this novel technology, greatly facilitating introduction and dissemination of the therapy. Since then considerable experience has been obtained treating a wider range of tumour histologies and increasing size of tumours which was not originally thought possible. A pan-European expert panel drawn from a range of disciplines from dermatology, general surgery, head and neck surgery, plastic surgery, and oncology met to form a consensus opinion to update the SOPs based on the experience obtained. This paper contains these updated recommendations for indications for electrochemotherapy, pre-treatment information and evaluation, treatment choices, as well as follow-up.",

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AU - Gehl, Julie

AU - Sersa, Gregor

AU - Matthiessen, Louise Wichmann

AU - Muir, Tobian

AU - Soden, Declan

AU - Occhini, Antonio

AU - Quaglino, Pietro

AU - Curatolo, Pietro

AU - Campana, Luca G.

AU - Kunte, Christian

AU - Clover, A. James P.

AU - Bertino, Giulia

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AU - Odili, Joy

AU - Dahlstrom, Karin

AU - Benazzo, Marco

AU - Mir, Lluis M.

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N2 - Electrochemotherapy is now in routine clinical use to treat cutaneous metastases of any histology, and is listed in national and international guidelines for cutaneous metastases and primary skin cancer. Electrochemotherapy is used by dermatologists, surgeons, and oncologists, and for different degrees and manifestations of metastases to skin and primary skin tumours not amenable to surgery. This treatment utilises electric pulses to permeabilize cell membranes in tumours, thus allowing a dramatic increase of the cytotoxicity of anti-cancer agents. Response rates, often after only one treatment, are very high across all tumour types. The most frequent indications are cutaneous metastases from malignant melanoma and breast cancer. In 2006, standard operating procedures (SOPs) were written for this novel technology, greatly facilitating introduction and dissemination of the therapy. Since then considerable experience has been obtained treating a wider range of tumour histologies and increasing size of tumours which was not originally thought possible. A pan-European expert panel drawn from a range of disciplines from dermatology, general surgery, head and neck surgery, plastic surgery, and oncology met to form a consensus opinion to update the SOPs based on the experience obtained. This paper contains these updated recommendations for indications for electrochemotherapy, pre-treatment information and evaluation, treatment choices, as well as follow-up.

AB - Electrochemotherapy is now in routine clinical use to treat cutaneous metastases of any histology, and is listed in national and international guidelines for cutaneous metastases and primary skin cancer. Electrochemotherapy is used by dermatologists, surgeons, and oncologists, and for different degrees and manifestations of metastases to skin and primary skin tumours not amenable to surgery. This treatment utilises electric pulses to permeabilize cell membranes in tumours, thus allowing a dramatic increase of the cytotoxicity of anti-cancer agents. Response rates, often after only one treatment, are very high across all tumour types. The most frequent indications are cutaneous metastases from malignant melanoma and breast cancer. In 2006, standard operating procedures (SOPs) were written for this novel technology, greatly facilitating introduction and dissemination of the therapy. Since then considerable experience has been obtained treating a wider range of tumour histologies and increasing size of tumours which was not originally thought possible. A pan-European expert panel drawn from a range of disciplines from dermatology, general surgery, head and neck surgery, plastic surgery, and oncology met to form a consensus opinion to update the SOPs based on the experience obtained. This paper contains these updated recommendations for indications for electrochemotherapy, pre-treatment information and evaluation, treatment choices, as well as follow-up.

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DO - 10.1080/0284186x.2018.1454602

M3 - Review

C2 - 29577784

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SP - 874

EP - 882

JO - Acta Oncologica

JF - Acta Oncologica

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Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases

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