Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature

Jennifer K. Bender; Vincent Cattoir; Kristin Hegstad; Ewa Sadowy; Teresa M. Coque; Henrik Westh; Anette M. Hammerum; Kirsten Schaffer; Karen Burns; Stephen Murchan; Carla Novais; Ana R. Freitas; Luísa Peixe; Maria Del Grosso; Annalisa Pantosti; Guido Werner

doi:10.1016/j.drup.2018.10.002

Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature

Jennifer K. Bender, Vincent Cattoir, Kristin Hegstad, Ewa Sadowy, Teresa M. Coque, Henrik Westh, Anette M. Hammerum, Kirsten Schaffer, Karen Burns, Stephen Murchan, Carla Novais, Ana R. Freitas, Luísa Peixe, Maria Del Grosso, Annalisa Pantosti, Guido Werner^*

^*Corresponding author for this work

Department of Clinical Medicine

61 Citations (Scopus)

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Abstract

Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and daptomycin has proven activity only at high dosages licensed for treating enterococcal endocarditis. Despite these pharmacological and therapeutic limitations, reports on resistance to these last-resort drugs in VRE, and enterococci in general, have increased in recent years. In this review, we briefly recapitulate the current knowledge on the mode of action as well as the known and novel mechanisms of resistance and describe surveillance data on resistance to linezolid, tigecycline and daptomycin in enterococci. In addition, we also suggest a common nomenclature for designating enterococci and VRE with resistances to these important last-resort antibiotics.

Original language	English
Journal	Drug Resistance Updates
Volume	40
Pages (from-to)	25-39
Number of pages	15
ISSN	1368-7646
DOIs	https://doi.org/10.1016/j.drup.2018.10.002
Publication status	Published - 2018

Keywords

Daptomycin
Linezolid
Tigecycline
vanA
vanB
VRE

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10.1016/j.drup.2018.10.002Licence: CC BY-NC-ND

Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclatureFinal published version, 581 KBLicence: CC BY-NC-ND

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Bender, J. K., Cattoir, V., Hegstad, K., Sadowy, E., Coque, T. M., Westh, H., Hammerum, A. M., Schaffer, K., Burns, K., Murchan, S., Novais, C., Freitas, A. R., Peixe, L., Del Grosso, M., Pantosti, A., & Werner, G. (2018). Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature. Drug Resistance Updates, 40, 25-39. https://doi.org/10.1016/j.drup.2018.10.002

Bender, JK, Cattoir, V, Hegstad, K, Sadowy, E, Coque, TM, Westh, H, Hammerum, AM, Schaffer, K, Burns, K, Murchan, S, Novais, C, Freitas, AR, Peixe, L, Del Grosso, M, Pantosti, A & Werner, G 2018, 'Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature', Drug Resistance Updates, vol. 40, pp. 25-39. https://doi.org/10.1016/j.drup.2018.10.002

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title = "Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature",

abstract = "Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and daptomycin has proven activity only at high dosages licensed for treating enterococcal endocarditis. Despite these pharmacological and therapeutic limitations, reports on resistance to these last-resort drugs in VRE, and enterococci in general, have increased in recent years. In this review, we briefly recapitulate the current knowledge on the mode of action as well as the known and novel mechanisms of resistance and describe surveillance data on resistance to linezolid, tigecycline and daptomycin in enterococci. In addition, we also suggest a common nomenclature for designating enterococci and VRE with resistances to these important last-resort antibiotics.",

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T2 - Towards a common nomenclature

AU - Bender, Jennifer K.

AU - Cattoir, Vincent

AU - Hegstad, Kristin

AU - Sadowy, Ewa

AU - Coque, Teresa M.

AU - Westh, Henrik

AU - Hammerum, Anette M.

AU - Schaffer, Kirsten

AU - Burns, Karen

AU - Murchan, Stephen

AU - Novais, Carla

AU - Freitas, Ana R.

AU - Peixe, Luísa

AU - Del Grosso, Maria

AU - Pantosti, Annalisa

AU - Werner, Guido

PY - 2018

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N2 - Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and daptomycin has proven activity only at high dosages licensed for treating enterococcal endocarditis. Despite these pharmacological and therapeutic limitations, reports on resistance to these last-resort drugs in VRE, and enterococci in general, have increased in recent years. In this review, we briefly recapitulate the current knowledge on the mode of action as well as the known and novel mechanisms of resistance and describe surveillance data on resistance to linezolid, tigecycline and daptomycin in enterococci. In addition, we also suggest a common nomenclature for designating enterococci and VRE with resistances to these important last-resort antibiotics.

AB - Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and daptomycin has proven activity only at high dosages licensed for treating enterococcal endocarditis. Despite these pharmacological and therapeutic limitations, reports on resistance to these last-resort drugs in VRE, and enterococci in general, have increased in recent years. In this review, we briefly recapitulate the current knowledge on the mode of action as well as the known and novel mechanisms of resistance and describe surveillance data on resistance to linezolid, tigecycline and daptomycin in enterococci. In addition, we also suggest a common nomenclature for designating enterococci and VRE with resistances to these important last-resort antibiotics.

KW - Daptomycin

KW - Linezolid

KW - Tigecycline

KW - vanA

KW - vanB

KW - VRE

U2 - 10.1016/j.drup.2018.10.002

DO - 10.1016/j.drup.2018.10.002

M3 - Journal article

C2 - 30447411

AN - SCOPUS:85056446191

SN - 1368-7646

VL - 40

SP - 25

EP - 39

JO - Drug Resistance Updates

JF - Drug Resistance Updates

ER -

Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature

Abstract

Keywords

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