Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease

Baljit S. Khakh; Vahri Beaumont; Roger Cachope; Ignacio Munoz-Sanjuan; Steven A. Goldman; Rosemarie Grantyn

doi:10.1016/j.tins.2017.05.002

Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease

Baljit S. Khakh, Vahri Beaumont, Roger Cachope, Ignacio Munoz-Sanjuan, Steven A. Goldman, Rosemarie Grantyn

68 Citations (Scopus)

Abstract

Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as well as on the use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD. Overall, the data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice. Additional exploration of astrocytes in HD mouse models and humans is needed and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies. Astrocytes are involved in HD. Astrocyte dysfunctions contribute to HD pathophysiology in mice. Transplanted astrocytes produce therapeutic benefit in HD model mice. Targeting astrocyte dysfunction may provide new therapeutic targets in HD.

Original language	English
Journal	Trends in Neurosciences
Volume	40
Issue number	7
Pages (from-to)	422-437
Number of pages	16
ISSN	0166-2236
DOIs	https://doi.org/10.1016/j.tins.2017.05.002
Publication status	Published - Jul 2017

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Journal Article
Review

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10.1016/j.tins.2017.05.002

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title = "Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease",

abstract = "Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as well as on the use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD. Overall, the data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice. Additional exploration of astrocytes in HD mouse models and humans is needed and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies. Astrocytes are involved in HD. Astrocyte dysfunctions contribute to HD pathophysiology in mice. Transplanted astrocytes produce therapeutic benefit in HD model mice. Targeting astrocyte dysfunction may provide new therapeutic targets in HD.",

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author = "Khakh, {Baljit S.} and Vahri Beaumont and Roger Cachope and Ignacio Munoz-Sanjuan and Goldman, {Steven A.} and Rosemarie Grantyn",

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T1 - Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease

AU - Khakh, Baljit S.

AU - Beaumont, Vahri

AU - Cachope, Roger

AU - Munoz-Sanjuan, Ignacio

AU - Goldman, Steven A.

AU - Grantyn, Rosemarie

PY - 2017/7

Y1 - 2017/7

N2 - Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as well as on the use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD. Overall, the data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice. Additional exploration of astrocytes in HD mouse models and humans is needed and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies. Astrocytes are involved in HD. Astrocyte dysfunctions contribute to HD pathophysiology in mice. Transplanted astrocytes produce therapeutic benefit in HD model mice. Targeting astrocyte dysfunction may provide new therapeutic targets in HD.

AB - Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as well as on the use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD. Overall, the data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice. Additional exploration of astrocytes in HD mouse models and humans is needed and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies. Astrocytes are involved in HD. Astrocyte dysfunctions contribute to HD pathophysiology in mice. Transplanted astrocytes produce therapeutic benefit in HD model mice. Targeting astrocyte dysfunction may provide new therapeutic targets in HD.

KW - Journal Article

KW - Review

U2 - 10.1016/j.tins.2017.05.002

DO - 10.1016/j.tins.2017.05.002

M3 - Review

C2 - 28578789

SN - 0166-2236

VL - 40

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EP - 437

JO - Trends in Neurosciences

JF - Trends in Neurosciences

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Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease

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