Ultrastructural localization of the core protein of a basement membrane-specific chondroitin sulfate proteoglycan in adult rat skin.

K J McCarthy; Y Horiguchi; J R Couchman; J D Fine

Ultrastructural localization of the core protein of a basement membrane-specific chondroitin sulfate proteoglycan in adult rat skin.

K J McCarthy, Y Horiguchi, J R Couchman, J D Fine

Nutritional Immunology

9 Citations (Scopus)

Abstract

Basement membranes are complex extracellular matrices present at epithelial/mesenchymal interfaces of tissues. The dermal-epidermal junction has been shown to contain numerous components, some of the most well known being laminin, types IV and VII collagens, heparan sulfate proteoglycan, fibronectin, and entactin/nidogen. IN this paper we show, using core protein-specific antibodies, the presence of a newly described basement membrane-specific chondroitin sulfate proteoglycan at the epithelial/mesenchymal interface of adult rat skin. Ultrastructurally, this antigen was proven to reside primarily within the basal lamina, apparently concentrated in the lamina densa. In addition, some of the proteoglycan was also present beneath the lamina densa, associated with the reticular lamina collagen fibrils.

Original language	English
Journal	Archives of Dermatological Research
Volume	282
Issue number	6
Pages (from-to)	397-401
Number of pages	4
ISSN	0340-3696
Publication status	Published - 1990

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@article{9feabcf0598011dd8d9f000ea68e967b,

title = "Ultrastructural localization of the core protein of a basement membrane-specific chondroitin sulfate proteoglycan in adult rat skin.",

abstract = "Basement membranes are complex extracellular matrices present at epithelial/mesenchymal interfaces of tissues. The dermal-epidermal junction has been shown to contain numerous components, some of the most well known being laminin, types IV and VII collagens, heparan sulfate proteoglycan, fibronectin, and entactin/nidogen. IN this paper we show, using core protein-specific antibodies, the presence of a newly described basement membrane-specific chondroitin sulfate proteoglycan at the epithelial/mesenchymal interface of adult rat skin. Ultrastructurally, this antigen was proven to reside primarily within the basal lamina, apparently concentrated in the lamina densa. In addition, some of the proteoglycan was also present beneath the lamina densa, associated with the reticular lamina collagen fibrils.",

author = "McCarthy, {K J} and Y Horiguchi and Couchman, {J R} and Fine, {J D}",

note = "Keywords: Animals; Antibodies, Monoclonal; Antigens, Surface; Basement Membrane; Cell Communication; Chondroitin Sulfates; Epidermis; Intercellular Junctions; Microscopy, Electron; Microscopy, Immunoelectron; Proteoglycans; Rats; Rats, Inbred Strains; Skin; Viral Core Proteins",

year = "1990",

language = "English",

volume = "282",

pages = "397--401",

journal = "Archiv f{\"u}r Dermatologische Forschung",

issn = "0340-3696",

publisher = "Springer",

number = "6",

}

TY - JOUR

T1 - Ultrastructural localization of the core protein of a basement membrane-specific chondroitin sulfate proteoglycan in adult rat skin.

AU - McCarthy, K J

AU - Horiguchi, Y

AU - Couchman, J R

AU - Fine, J D

N1 - Keywords: Animals; Antibodies, Monoclonal; Antigens, Surface; Basement Membrane; Cell Communication; Chondroitin Sulfates; Epidermis; Intercellular Junctions; Microscopy, Electron; Microscopy, Immunoelectron; Proteoglycans; Rats; Rats, Inbred Strains; Skin; Viral Core Proteins

PY - 1990

Y1 - 1990

N2 - Basement membranes are complex extracellular matrices present at epithelial/mesenchymal interfaces of tissues. The dermal-epidermal junction has been shown to contain numerous components, some of the most well known being laminin, types IV and VII collagens, heparan sulfate proteoglycan, fibronectin, and entactin/nidogen. IN this paper we show, using core protein-specific antibodies, the presence of a newly described basement membrane-specific chondroitin sulfate proteoglycan at the epithelial/mesenchymal interface of adult rat skin. Ultrastructurally, this antigen was proven to reside primarily within the basal lamina, apparently concentrated in the lamina densa. In addition, some of the proteoglycan was also present beneath the lamina densa, associated with the reticular lamina collagen fibrils.

AB - Basement membranes are complex extracellular matrices present at epithelial/mesenchymal interfaces of tissues. The dermal-epidermal junction has been shown to contain numerous components, some of the most well known being laminin, types IV and VII collagens, heparan sulfate proteoglycan, fibronectin, and entactin/nidogen. IN this paper we show, using core protein-specific antibodies, the presence of a newly described basement membrane-specific chondroitin sulfate proteoglycan at the epithelial/mesenchymal interface of adult rat skin. Ultrastructurally, this antigen was proven to reside primarily within the basal lamina, apparently concentrated in the lamina densa. In addition, some of the proteoglycan was also present beneath the lamina densa, associated with the reticular lamina collagen fibrils.

M3 - Journal article

C2 - 2124436

SN - 0340-3696

VL - 282

SP - 397

EP - 401

JO - Archiv für Dermatologische Forschung

JF - Archiv für Dermatologische Forschung

IS - 6

ER -

Ultrastructural localization of the core protein of a basement membrane-specific chondroitin sulfate proteoglycan in adult rat skin.

Abstract

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