TY - JOUR
T1 - Ultra-high field MR angiography in human migraine models
T2 - A 3.0 T/7.0 T comparison study
AU - Christensen, Casper Emil
AU - Younis, Samaira
AU - Lindberg, Ulrich
AU - Boer, Vincent Oltman
AU - De Koning, Patrick
AU - Petersen, Esben Thade
AU - Paulson, Olaf Bjarne
AU - Larsson, Henrik Bo Wiberg
AU - Amin, Faisal Mohammad
AU - Ashina, Messoud
PY - 2019
Y1 - 2019
N2 - Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0 T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Methods: Five subjects completed two sessions at respectively 3.0 T and 7.0 T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Results: Standard deviations of arterial circumference revealed no difference between 3.0 T and 7.0 T measurements (p = 0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation after sildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findings from earlier. The implemented software update improved variance in circumference measurements in the intradural middle meningeal artery, which should be exploited in future studies. Trial registration: The study is part of a parent study, which is registered at ClinicalTrials.gov (NCT03143465).
AB - Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0 T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Methods: Five subjects completed two sessions at respectively 3.0 T and 7.0 T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Results: Standard deviations of arterial circumference revealed no difference between 3.0 T and 7.0 T measurements (p = 0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation after sildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findings from earlier. The implemented software update improved variance in circumference measurements in the intradural middle meningeal artery, which should be exploited in future studies. Trial registration: The study is part of a parent study, which is registered at ClinicalTrials.gov (NCT03143465).
KW - Calcitonin gene-related peptide
KW - Dura mater
KW - Middle meningeal artery
KW - Neurovascular
KW - Sildenafil
UR - https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1014-z
U2 - 10.1186/s10194-019-0996-x
DO - 10.1186/s10194-019-0996-x
M3 - Journal article
C2 - 31060491
AN - SCOPUS:85065662996
SN - 1129-2369
VL - 20
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
M1 - 48
ER -