Type 3 ILCs in lung disease

Amanda Ardain; James Zachary Porterfield; Henrik N. Kløverpris; Alasdair Leslie

doi:10.3389/fimmu.2019.00092

Type 3 ILCs in lung disease

Amanda Ardain, James Zachary Porterfield, Henrik N. Kløverpris, Alasdair Leslie^*

^*Corresponding author for this work

11 Citations (Scopus)

30 Downloads (Pure)

Abstract

The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects.

Original language	English
Article number	92
Journal	Frontiers in Immunology
Volume	10
Issue number	JAN
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2019.00092
Publication status	Published - 2019

Keywords

Airway hypersensitivity
COPD
ILC3
Lung disease
Pnemonia
Pulmonary fibrosis
Tuberulosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Type 3 ILCs in lung disease",

abstract = "The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects.",

keywords = "Airway hypersensitivity, COPD, ILC3, Lung disease, Pnemonia, Pulmonary fibrosis, Tuberulosis",

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AU - Ardain, Amanda

AU - Porterfield, James Zachary

AU - Kløverpris, Henrik N.

AU - Leslie, Alasdair

PY - 2019

Y1 - 2019

N2 - The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects.

AB - The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects.

KW - Airway hypersensitivity

KW - COPD

KW - ILC3

KW - Lung disease

KW - Pnemonia

KW - Pulmonary fibrosis

KW - Tuberulosis

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DO - 10.3389/fimmu.2019.00092

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JO - Frontiers in Immunology

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ER -

Type 3 ILCs in lung disease

Abstract

Keywords

UN SDGs

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