Type 2 diabetes and psoriasis: links and risks

Jesper Gronlund Holm; Simon Francis Thomsen

doi:10.2147/PTT.S159163

Type 2 diabetes and psoriasis: links and risks

Jesper Gronlund Holm, Simon Francis Thomsen

Inflammation, Metabolism and Oxidation

5 Downloads (Pure)

Abstract

Psoriasis (PsO) is one of the most common chronic inflammatory skin diseases with a world prevalence of 2%-4%. The increasing knowledge of the mechanisms driving PsO has raised focus on existing links to metabolic syndrome and type 2 diabetes (T2D). We reviewed the existing literature of the prevalence and risk of T2D in patients with PsO. The studies reviewed were mainly large retrospective cohort and case-control studies, showing an increased prevalence of T2D in PsO patients compared to controls, particularly in late onset (type 2) PsO. T2D prevalence did not correlate to patient age or severity of PsO in the reviewed studies. Conclusively, T2D was found to be more prevalent in patients with PsO compared to the background population. Several mechanisms involved in lipid transportation seem to be upregulated in PsO patients. Physicians play a key role concerning information about known comorbidity and promotion of early prophylaxis in patients with PsO.

Original language	English
Journal	Psoriasis: Targets and Therapy
Volume	9
Pages (from-to)	1-6
DOIs	https://doi.org/10.2147/PTT.S159163
Publication status	Published - 2019

Keywords

psoriasis
type 2 diabetes
association
risk
link

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2147/PTT.S159163Licence: CC BY-NC

OA-TypeFinal published version, 143 KBLicence: CC BY-NC

Cite this

@article{b49ac6c708ed474580fbc2c0d3e6321e,

title = "Type 2 diabetes and psoriasis: links and risks",

abstract = "Psoriasis (PsO) is one of the most common chronic inflammatory skin diseases with a world prevalence of 2%-4%. The increasing knowledge of the mechanisms driving PsO has raised focus on existing links to metabolic syndrome and type 2 diabetes (T2D). We reviewed the existing literature of the prevalence and risk of T2D in patients with PsO. The studies reviewed were mainly large retrospective cohort and case-control studies, showing an increased prevalence of T2D in PsO patients compared to controls, particularly in late onset (type 2) PsO. T2D prevalence did not correlate to patient age or severity of PsO in the reviewed studies. Conclusively, T2D was found to be more prevalent in patients with PsO compared to the background population. Several mechanisms involved in lipid transportation seem to be upregulated in PsO patients. Physicians play a key role concerning information about known comorbidity and promotion of early prophylaxis in patients with PsO.",

keywords = "psoriasis, type 2 diabetes, association, risk, link",

author = "Holm, {Jesper Gronlund} and Thomsen, {Simon Francis}",

year = "2019",

doi = "10.2147/PTT.S159163",

language = "English",

volume = "9",

pages = " 1--6",

journal = "Psoriasis: Targets and Therapy",

issn = "2230-326X",

publisher = "Dove Medical Press Ltd",

}

TY - JOUR

T1 - Type 2 diabetes and psoriasis

T2 - links and risks

AU - Holm, Jesper Gronlund

AU - Thomsen, Simon Francis

PY - 2019

Y1 - 2019

N2 - Psoriasis (PsO) is one of the most common chronic inflammatory skin diseases with a world prevalence of 2%-4%. The increasing knowledge of the mechanisms driving PsO has raised focus on existing links to metabolic syndrome and type 2 diabetes (T2D). We reviewed the existing literature of the prevalence and risk of T2D in patients with PsO. The studies reviewed were mainly large retrospective cohort and case-control studies, showing an increased prevalence of T2D in PsO patients compared to controls, particularly in late onset (type 2) PsO. T2D prevalence did not correlate to patient age or severity of PsO in the reviewed studies. Conclusively, T2D was found to be more prevalent in patients with PsO compared to the background population. Several mechanisms involved in lipid transportation seem to be upregulated in PsO patients. Physicians play a key role concerning information about known comorbidity and promotion of early prophylaxis in patients with PsO.

AB - Psoriasis (PsO) is one of the most common chronic inflammatory skin diseases with a world prevalence of 2%-4%. The increasing knowledge of the mechanisms driving PsO has raised focus on existing links to metabolic syndrome and type 2 diabetes (T2D). We reviewed the existing literature of the prevalence and risk of T2D in patients with PsO. The studies reviewed were mainly large retrospective cohort and case-control studies, showing an increased prevalence of T2D in PsO patients compared to controls, particularly in late onset (type 2) PsO. T2D prevalence did not correlate to patient age or severity of PsO in the reviewed studies. Conclusively, T2D was found to be more prevalent in patients with PsO compared to the background population. Several mechanisms involved in lipid transportation seem to be upregulated in PsO patients. Physicians play a key role concerning information about known comorbidity and promotion of early prophylaxis in patients with PsO.

KW - psoriasis

KW - type 2 diabetes

KW - association

KW - risk

KW - link

U2 - 10.2147/PTT.S159163

DO - 10.2147/PTT.S159163

M3 - Review

C2 - 30697518

SN - 2230-326X

VL - 9

SP - 1

EP - 6

JO - Psoriasis: Targets and Therapy

JF - Psoriasis: Targets and Therapy

ER -