Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study

Jonas L. Isaksen; Claus Graff; Christina Ellervik; Jan Skov Jensen; Henrik Ullits Andersen; Peter Rossing; Jørgen K. Kanters; Magnus Thorsten Jensen

doi:10.1016/j.jelectrocard.2018.05.015

Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study

Jonas L. Isaksen, Claus Graff, Christina Ellervik, Jan Skov Jensen, Henrik Ullits Andersen, Peter Rossing, Jørgen K. Kanters, Magnus Thorsten Jensen

2 Citations (Scopus)

Abstract

Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.

Original language	English
Journal	Journal of Electrocardiology
Volume	51
Issue number	6
Pages (from-to)	S72-S77
ISSN	0022-0736
DOIs	https://doi.org/10.1016/j.jelectrocard.2018.05.015
Publication status	Published - 1 Nov 2018

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10.1016/j.jelectrocard.2018.05.015

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@article{5286865236c642a6ae07841331427dac,

title = "Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study",

abstract = "Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.",

author = "Isaksen, {Jonas L.} and Claus Graff and Christina Ellervik and Jensen, {Jan Skov} and Andersen, {Henrik Ullits} and Peter Rossing and Kanters, {J{\o}rgen K.} and Jensen, {Magnus Thorsten}",

year = "2018",

month = nov,

day = "1",

doi = "10.1016/j.jelectrocard.2018.05.015",

language = "English",

volume = "51",

pages = "S72--S77",

journal = "Journal of Electrocardiology",

issn = "0022-0736",

publisher = "Churchill Livingstone",

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TY - JOUR

T1 - Type 1 diabetes is associated with T-wave morphology changes

T2 - The Thousand & 1 Study

AU - Isaksen, Jonas L.

AU - Graff, Claus

AU - Ellervik, Christina

AU - Jensen, Jan Skov

AU - Andersen, Henrik Ullits

AU - Rossing, Peter

AU - Kanters, Jørgen K.

AU - Jensen, Magnus Thorsten

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.

AB - Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.

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U2 - 10.1016/j.jelectrocard.2018.05.015

DO - 10.1016/j.jelectrocard.2018.05.015

M3 - Journal article

C2 - 30007776

SN - 0022-0736

VL - 51

SP - S72-S77

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 6

ER -

Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study

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