Gudmundsson, J., Sulem, P., Steinthorsdottir, V., Bergthorsson, J. T., Thorleifsson, G., Manolescu, A., Rafnar, T., Gudbjartsson, D., Agnarsson, B. A., Baker, A., Sigurdsson, A., Benediktsdottir, K. R., Jakobsdottir, M., Blondal, T., Stacey, S. N., Helgason, A., Gunnarsdottir, S., Olafsdottir, A., Kristinsson, K. T., ... Stefansson, K. (2007). Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nature Genetics, 39(8), 977-983. https://doi.org/10.1038/ng2062
Gudmundsson, J, Sulem, P, Steinthorsdottir, V, Bergthorsson, JT, Thorleifsson, G, Manolescu, A, Rafnar, T, Gudbjartsson, D, Agnarsson, BA, Baker, A, Sigurdsson, A, Benediktsdottir, KR, Jakobsdottir, M, Blondal, T, Stacey, SN, Helgason, A, Gunnarsdottir, S, Olafsdottir, A, Kristinsson, KT, Birgisdottir, B, Ghosh, S, Thorlacius, S, Magnusdottir, D, Stefansdottir, G, Kristjansson, K, Bagger, Y, Wilensky, RL, Reilly, MP, Morris, AD, Kimber, CH, Adeyemo, A, Chen, Y, Zhou, J, So, W-Y, Tong, PCY, Ng, MCY, Hansen, T, Andersen, G, Borch-Johnsen, K, Jorgensen, T, Tres, A, Fuertes, F, Ruiz-Echarri, M, Asin, L, Saez, B, van Boven, E, Klaver, S, Swinkels, DW, Aben, KK, Graif, T, Cashy, J, Suarez, BK, van Vierssen Trip, O, Frigge, ML, Ober, C, Hofker, MH, Wijmenga, C, Christiansen, C, Rader, DJ, Palmer, CNA, Rotimi, C, Chan, JCN, Pedersen, O, Sigurdsson, G, Benediktsson, R, Jonsson, E, Einarsson, GV, Mayordomo, JI, Catalona, WJ, Kiemeney, LA, Barkardottir, RB, Gulcher, JR, Thorsteinsdottir, U, Kong, A & Stefansson, K 2007, 'Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes', Nature Genetics, vol. 39, no. 8, pp. 977-983. https://doi.org/10.1038/ng2062
@article{20979a8020ec11ddbc23000ea68e967b,
title = "Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes",
abstract = "We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.",
keywords = "Case-Control Studies, Chromosomes, Human, Pair 17, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Haplotypes, Hepatocyte Nuclear Factor 1-beta, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms",
author = "Julius Gudmundsson and Patrick Sulem and Valgerdur Steinthorsdottir and Bergthorsson, {Jon T} and Gudmar Thorleifsson and Andrei Manolescu and Thorunn Rafnar and Daniel Gudbjartsson and Agnarsson, {Bjarni A} and Adam Baker and Asgeir Sigurdsson and Benediktsdottir, {Kristrun R} and Margret Jakobsdottir and Thorarinn Blondal and Stacey, {Simon N} and Agnar Helgason and Steinunn Gunnarsdottir and Adalheidur Olafsdottir and Kristinsson, {Kari T} and Birgitta Birgisdottir and Shyamali Ghosh and Steinunn Thorlacius and Dana Magnusdottir and Gerdur Stefansdottir and Kristleifur Kristjansson and Yu Bagger and Wilensky, {Robert L} and Reilly, {Muredach P} and Morris, {Andrew D} and Kimber, {Charlotte H} and Adebowale Adeyemo and Yuanxiu Chen and Jie Zhou and Wing-Yee So and Tong, {Peter C Y} and Ng, {Maggie C Y} and Torben Hansen and Gitte Andersen and Knut Borch-Johnsen and Torben Jorgensen and Alejandro Tres and Fernando Fuertes and Manuel Ruiz-Echarri and Laura Asin and Berta Saez and {van Boven}, Erica and Siem Klaver and Swinkels, {Dorine W} and Aben, {Katja K} and Theresa Graif and John Cashy and Suarez, {Brian K} and {van Vierssen Trip}, Onco and Frigge, {Michael L} and Carole Ober and Hofker, {Marten H} and Cisca Wijmenga and Claus Christiansen and Rader, {Daniel J} and Palmer, {Colin N A} and Charles Rotimi and Chan, {Juliana C N} and Oluf Pedersen and Gunnar Sigurdsson and Rafn Benediktsson and Eirikur Jonsson and Einarsson, {Gudmundur V} and Mayordomo, {Jose I} and Catalona, {William J} and Kiemeney, {Lambertus A} and Barkardottir, {Rosa B} and Gulcher, {Jeffrey R} and Unnur Thorsteinsdottir and Augustine Kong and Kari Stefansson",
year = "2007",
doi = "10.1038/ng2062",
language = "English",
volume = "39",
pages = "977--983",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "8",
}
TY - JOUR
T1 - Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
AU - Gudmundsson, Julius
AU - Sulem, Patrick
AU - Steinthorsdottir, Valgerdur
AU - Bergthorsson, Jon T
AU - Thorleifsson, Gudmar
AU - Manolescu, Andrei
AU - Rafnar, Thorunn
AU - Gudbjartsson, Daniel
AU - Agnarsson, Bjarni A
AU - Baker, Adam
AU - Sigurdsson, Asgeir
AU - Benediktsdottir, Kristrun R
AU - Jakobsdottir, Margret
AU - Blondal, Thorarinn
AU - Stacey, Simon N
AU - Helgason, Agnar
AU - Gunnarsdottir, Steinunn
AU - Olafsdottir, Adalheidur
AU - Kristinsson, Kari T
AU - Birgisdottir, Birgitta
AU - Ghosh, Shyamali
AU - Thorlacius, Steinunn
AU - Magnusdottir, Dana
AU - Stefansdottir, Gerdur
AU - Kristjansson, Kristleifur
AU - Bagger, Yu
AU - Wilensky, Robert L
AU - Reilly, Muredach P
AU - Morris, Andrew D
AU - Kimber, Charlotte H
AU - Adeyemo, Adebowale
AU - Chen, Yuanxiu
AU - Zhou, Jie
AU - So, Wing-Yee
AU - Tong, Peter C Y
AU - Ng, Maggie C Y
AU - Hansen, Torben
AU - Andersen, Gitte
AU - Borch-Johnsen, Knut
AU - Jorgensen, Torben
AU - Tres, Alejandro
AU - Fuertes, Fernando
AU - Ruiz-Echarri, Manuel
AU - Asin, Laura
AU - Saez, Berta
AU - van Boven, Erica
AU - Klaver, Siem
AU - Swinkels, Dorine W
AU - Aben, Katja K
AU - Graif, Theresa
AU - Cashy, John
AU - Suarez, Brian K
AU - van Vierssen Trip, Onco
AU - Frigge, Michael L
AU - Ober, Carole
AU - Hofker, Marten H
AU - Wijmenga, Cisca
AU - Christiansen, Claus
AU - Rader, Daniel J
AU - Palmer, Colin N A
AU - Rotimi, Charles
AU - Chan, Juliana C N
AU - Pedersen, Oluf
AU - Sigurdsson, Gunnar
AU - Benediktsson, Rafn
AU - Jonsson, Eirikur
AU - Einarsson, Gudmundur V
AU - Mayordomo, Jose I
AU - Catalona, William J
AU - Kiemeney, Lambertus A
AU - Barkardottir, Rosa B
AU - Gulcher, Jeffrey R
AU - Thorsteinsdottir, Unnur
AU - Kong, Augustine
AU - Stefansson, Kari
PY - 2007
Y1 - 2007
N2 - We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.
AB - We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.
KW - Case-Control Studies
KW - Chromosomes, Human, Pair 17
KW - Diabetes Mellitus, Type 2
KW - Genetic Predisposition to Disease
KW - Haplotypes
KW - Hepatocyte Nuclear Factor 1-beta
KW - Humans
KW - Male
KW - Polymorphism, Single Nucleotide
KW - Prostatic Neoplasms
U2 - 10.1038/ng2062
DO - 10.1038/ng2062
M3 - Journal article
C2 - 17603485
SN - 1061-4036
VL - 39
SP - 977
EP - 983
JO - Nature Genetics
JF - Nature Genetics
IS - 8
ER -
