Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Yoshie Yokoyama; Aline Jelenkovic; Reijo Sund; Joohon Sung; John L Hopper; Syuichi Ooki; Kauko Heikkilä; Sari Aaltonen; Adam D Tarnoki; David L Tarnoki; Gonneke Willemsen; Meike Bartels; Toos C E M van Beijsterveldt; Kimberly J Saudino; Tessa L Cutler; Tracy L Nelson; Keith E Whitfield; Jane Wardle; Clare H Llewellyn; Abigail Fisher; Mingguang He; Xiaohu Ding; Morten Bjerregaard-Andersen; Henning Beck-Nielsen; Morten Sodemann; Yun-Mi Song; Sarah Yang; Kayoung Lee; Hoe-Uk Jeong; Ariel Knafo-Noam; David Mankuta; Lior Abramson; S Alexandra Burt; Kelly L Klump; Juan R Ordoñana; Juan F Sánchez-Romera; Lucia Colodro-Conde; Jennifer R Harris; Ingunn Brandt; Thomas Sevenius Nilsen; Jeffrey M Craig; Richard Saffery; Fuling Ji; Feng Ning; Zengchang Pang; Lise Dubois; Michel Boivin; Mara Brendgen; Ginette Dionne; Frank Vitaro; Nicholas G. Martin; Sarah E. Medland; Grant W. Montgomery; Patrik K E Magnusson; Nancy L Pedersen; Anna K Dahl Aslan; Per Tynelius; Claire M A Haworth; Robert Plomin; Esther Rebato; Richard J Rose; Jack H Goldberg; Finn Rasmussen; Yoon-Mi Hur; Thorkild I A Sørensen; Dorret I Boomsma; Jaakko Kaprio; Karri Silventoinen

doi:10.1017/thg.2016.11

Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Yoshie Yokoyama, Aline Jelenkovic, Reijo Sund, Joohon Sung, John L Hopper, Syuichi Ooki, Kauko Heikkilä, Sari Aaltonen, Adam D Tarnoki, David L Tarnoki, Gonneke Willemsen, Meike Bartels, Toos C E M van Beijsterveldt, Kimberly J Saudino, Tessa L Cutler, Tracy L Nelson, Keith E Whitfield, Jane Wardle, Clare H Llewellyn, Abigail FisherMingguang He, Xiaohu Ding, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Yun-Mi Song, Sarah Yang, Kayoung Lee, Hoe-Uk Jeong, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S Alexandra Burt, Kelly L Klump, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Jeffrey M Craig, Richard Saffery, Fuling Ji, Feng Ning, Zengchang Pang, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Patrik K E Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Per Tynelius, Claire M A Haworth, Robert Plomin, Esther Rebato, Richard J Rose, Jack H Goldberg, Finn Rasmussen, Yoon-Mi Hur, Thorkild I A Sørensen, Dorret I Boomsma, Jaakko Kaprio, Karri Silventoinen

Department of Public Health

11 Citations (Scopus)

Abstract

We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.

Original language	English
Journal	Twin Research and Human Genetics
Volume	19
Issue number	2
Pages (from-to)	112-24
Number of pages	13
ISSN	1832-4274
DOIs	https://doi.org/10.1017/thg.2016.11
Publication status	Published - 1 Apr 2016

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Birth Order
Body Height
Body Mass Index
Child
Child, Preschool
Female
Humans
Infant
Male
Middle Aged
Pregnancy
Pregnancy, Twin
Twins, Dizygotic
Twins, Monozygotic
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

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Yokoyama, Y., Jelenkovic, A., Sund, R., Sung, J., Hopper, J. L., Ooki, S., Heikkilä, K., Aaltonen, S., Tarnoki, A. D., Tarnoki, D. L., Willemsen, G., Bartels, M., van Beijsterveldt, T. C. E. M., Saudino, K. J., Cutler, T. L., Nelson, T. L., Whitfield, K. E., Wardle, J., Llewellyn, C. H., ... Silventoinen, K. (2016). Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project. Twin Research and Human Genetics, 19(2), 112-24. https://doi.org/10.1017/thg.2016.11

Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age : A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project. / Yokoyama, Yoshie; Jelenkovic, Aline; Sund, Reijo et al.

In: Twin Research and Human Genetics, Vol. 19, No. 2, 01.04.2016, p. 112-24.

Research output: Contribution to journal › Journal article › Research › peer-review

Yokoyama, Y, Jelenkovic, A, Sund, R, Sung, J, Hopper, JL, Ooki, S, Heikkilä, K, Aaltonen, S, Tarnoki, AD, Tarnoki, DL, Willemsen, G, Bartels, M, van Beijsterveldt, TCEM, Saudino, KJ, Cutler, TL, Nelson, TL, Whitfield, KE, Wardle, J, Llewellyn, CH, Fisher, A, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Song, Y-M, Yang, S, Lee, K, Jeong, H-U, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Ordoñana, JR, Sánchez-Romera, JF, Colodro-Conde, L, Harris, JR, Brandt, I, Nilsen, TS, Craig, JM, Saffery, R, Ji, F, Ning, F, Pang, Z, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Magnusson, PKE, Pedersen, NL, Aslan, AKD, Tynelius, P, Haworth, CMA, Plomin, R, Rebato, E, Rose, RJ, Goldberg, JH, Rasmussen, F, Hur, Y-M, Sørensen, TIA, Boomsma, DI, Kaprio, J & Silventoinen, K 2016, 'Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project', Twin Research and Human Genetics, vol. 19, no. 2, pp. 112-24. https://doi.org/10.1017/thg.2016.11

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title = "Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project",

abstract = "We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Birth Order, Body Height, Body Mass Index, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Pregnancy, Pregnancy, Twin, Twins, Dizygotic, Twins, Monozygotic, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",

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T1 - Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age

T2 - A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

AU - Yokoyama, Yoshie

AU - Jelenkovic, Aline

AU - Sund, Reijo

AU - Sung, Joohon

AU - Hopper, John L

AU - Ooki, Syuichi

AU - Heikkilä, Kauko

AU - Aaltonen, Sari

AU - Tarnoki, Adam D

AU - Tarnoki, David L

AU - Willemsen, Gonneke

AU - Bartels, Meike

AU - van Beijsterveldt, Toos C E M

AU - Saudino, Kimberly J

AU - Cutler, Tessa L

AU - Nelson, Tracy L

AU - Whitfield, Keith E

AU - Wardle, Jane

AU - Llewellyn, Clare H

AU - Fisher, Abigail

AU - He, Mingguang

AU - Ding, Xiaohu

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Song, Yun-Mi

AU - Yang, Sarah

AU - Lee, Kayoung

AU - Jeong, Hoe-Uk

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Burt, S Alexandra

AU - Klump, Kelly L

AU - Ordoñana, Juan R

AU - Sánchez-Romera, Juan F

AU - Colodro-Conde, Lucia

AU - Harris, Jennifer R

AU - Brandt, Ingunn

AU - Nilsen, Thomas Sevenius

AU - Craig, Jeffrey M

AU - Saffery, Richard

AU - Ji, Fuling

AU - Ning, Feng

AU - Pang, Zengchang

AU - Dubois, Lise

AU - Boivin, Michel

AU - Brendgen, Mara

AU - Dionne, Ginette

AU - Vitaro, Frank

AU - Martin, Nicholas G.

AU - Medland, Sarah E.

AU - Montgomery, Grant W.

AU - Magnusson, Patrik K E

AU - Pedersen, Nancy L

AU - Aslan, Anna K Dahl

AU - Tynelius, Per

AU - Haworth, Claire M A

AU - Plomin, Robert

AU - Rebato, Esther

AU - Rose, Richard J

AU - Goldberg, Jack H

AU - Rasmussen, Finn

AU - Hur, Yoon-Mi

AU - Sørensen, Thorkild I A

AU - Boomsma, Dorret I

AU - Kaprio, Jaakko

AU - Silventoinen, Karri

PY - 2016/4/1

Y1 - 2016/4/1

N2 - We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.

AB - We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Birth Order

KW - Body Height

KW - Body Mass Index

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Middle Aged

KW - Pregnancy

KW - Pregnancy, Twin

KW - Twins, Dizygotic

KW - Twins, Monozygotic

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1017/thg.2016.11

DO - 10.1017/thg.2016.11

M3 - Journal article

C2 - 26996222

SN - 1832-4274

VL - 19

SP - 112

EP - 124

JO - Twin Research

JF - Twin Research

IS - 2

ER -

Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Abstract

Keywords

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