Tumors in the parotid are not relatively more often malignant in children than in adults

TY - JOUR

T1 - Tumors in the parotid are not relatively more often malignant in children than in adults

AU - Stevens, E

AU - Andreasen, S

AU - Bjørndal, Kristine

AU - Homøe, P

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/8

Y1 - 2015/8

N2 - INTRODUCTION: Tumors of the parotid gland in children are rare and very little data has been published regarding the incidence of these tumors. We present a nationwide survey on this topic.METHODS: Data regarding benign and malignant tumors in the parotid gland in children from January 1st, 1990 to December 31st, 2005 in Denmark was collected retrospectively from nationwide registries. This generated 61 patients for inclusion in this study.RESULTS: 85% of the tumors were benign and the malignant tumors made up the last 15%. The most common of the malignant tumors was the acinic cell carcinoma (n=4) followed by the mucoepidermoid carcinoma (n=3) and adenoid cystic carcinoma (n=2). The overall female-to-male ratio was 1.18, with a ratio of 1.08 and 2.0 in the benign and malignant groups, respectively. At the end of follow-up (August 1st, 2014) two patients had died, one with adenoid cystic carcinoma and one with mucoepidermoid carcinoma. Both patients had perineural invasion and involved resection margins at presentation. The incidence was 0.12 and 0.53 per 100,000 children of the malignant and benign tumors, respectively.CONCLUSION: Pleomorphic adenomas were the predominant neoplasm in the parotid gland in children. The most frequent of the malignant tumors was the acinic cell carcinoma, which is in contrast to previous studies. The proportion of malignant-to-benign parotid gland tumors is in contrast to earlier study reports not higher in children than in adults.

AB - INTRODUCTION: Tumors of the parotid gland in children are rare and very little data has been published regarding the incidence of these tumors. We present a nationwide survey on this topic.METHODS: Data regarding benign and malignant tumors in the parotid gland in children from January 1st, 1990 to December 31st, 2005 in Denmark was collected retrospectively from nationwide registries. This generated 61 patients for inclusion in this study.RESULTS: 85% of the tumors were benign and the malignant tumors made up the last 15%. The most common of the malignant tumors was the acinic cell carcinoma (n=4) followed by the mucoepidermoid carcinoma (n=3) and adenoid cystic carcinoma (n=2). The overall female-to-male ratio was 1.18, with a ratio of 1.08 and 2.0 in the benign and malignant groups, respectively. At the end of follow-up (August 1st, 2014) two patients had died, one with adenoid cystic carcinoma and one with mucoepidermoid carcinoma. Both patients had perineural invasion and involved resection margins at presentation. The incidence was 0.12 and 0.53 per 100,000 children of the malignant and benign tumors, respectively.CONCLUSION: Pleomorphic adenomas were the predominant neoplasm in the parotid gland in children. The most frequent of the malignant tumors was the acinic cell carcinoma, which is in contrast to previous studies. The proportion of malignant-to-benign parotid gland tumors is in contrast to earlier study reports not higher in children than in adults.

KW - Adenoma, Pleomorphic

KW - Adolescent

KW - Carcinoma, Acinar Cell

KW - Carcinoma, Adenoid Cystic

KW - Carcinoma, Mucoepidermoid

KW - Child

KW - Denmark

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Neoplasm Invasiveness

KW - Neoplasm, Residual

KW - Parotid Neoplasms

KW - Registries

KW - Retrospective Studies

KW - Journal Article

U2 - 10.1016/j.ijporl.2015.04.035

DO - 10.1016/j.ijporl.2015.04.035

M3 - Journal article

C2 - 25953456

SN - 0165-5876

VL - 79

SP - 1192

EP - 1195

JO - International Journal of Pediatric Otorhinolaryngology

JF - International Journal of Pediatric Otorhinolaryngology

IS - 8

ER -